教育背景
2000.09- 2004.06 浙江大學 化學系 本科
2004.09—2009.06 浙江大學 化學系 博士
2009.07—2011.05 美國華盛頓州立大學 生物化學研究所 博士后
代表論文
主要研究方向：海洋藥用生物資源與創(chuàng)新藥物研究
（1）海洋藥物先導化合物發(fā)現(xiàn)。在國際上首次從30余種海洋生物中發(fā)現(xiàn)新化合物123個，新骨架化合物8個。通過高通量活性篩選，獲得了3個抗阿爾茲海默癥（AD）先導化合物，與寧波大學醫(yī)學院崔巍教授合作，首次報道了Eckmaxol和Fucoxanthin等抗AD先導化合物的作用機制（ACS Chem. Neurosci.2018, 9, 1349?1356；Oxid. Med. Cell. Longev.2017, 6792543；Mar. Drugs2017, 15, 260）。此外，還發(fā)現(xiàn)了7個抗腫瘤（Harmful Algae2016, 58, 66u201373；Appl. Microbiol. Biotechnol.2014, 98, 4369-4377；Mar. Drugs2019, 17, 283）、5個抗菌（Front. Microbiol.2019, 10, 2846；Mar. Drugs2019, 17, 344;J. Antibiot.2018, 71, 902-904）藥物先導化合物。為開發(fā)具有知識產(chǎn)權(quán)的新藥奠定了基礎。
（2）海洋天然產(chǎn)物高效制備新方法。針對“藍色藥庫”藥源瓶頸的高效制備關(guān)鍵技術(shù)難題，建立了Eckmaxol、Macrolactins等20余種天然藥物先導化合物的高效分離純化新方法，取得了系列研究成果（J. Chromatogr. A2013, 1272, 15-19；J. Sep. Sci.2019, 42, 2510u20132516；Mar. Drugs2018, 16, 73）。實現(xiàn)了從粗提物到純化合物的一步式制備分離，回收率達到90%以上，高效制備方法的建立將加速海洋活性物質(zhì)的新藥創(chuàng)制進程。
（3）海洋“難培養(yǎng)”微生物新資源挖掘。針對99%以上海洋微生物無法在實驗室常規(guī)條件下培養(yǎng)的關(guān)鍵技術(shù)難題，與Slava Epstein教授開展國際合作，首次改進和運用iChip、Diffusion Chamber等新型微生物原位培養(yǎng)技術(shù)深入挖掘海洋“難培養(yǎng)”微生物新資源，已發(fā)現(xiàn)新種378個，隨機培養(yǎng)的出新率達到50%以上，目前已完成并發(fā)表了其中8個海洋微生物新種的系統(tǒng)分類鑒定與基因組分析（Int. J. Syst. Evol. Microbiol.2019, 69, 3293u20133298;Int. J. Syst. Evol. Microbiol.2018, 68, 2813-2818；Antonie van Leeuwenhoek2018, 111, 1855u20131862），從中發(fā)現(xiàn)了一系列新天然產(chǎn)物（Chem. Biodivers.In press，2020，中國藥學會海洋藥物專業(yè)委員會�？瑸橥黄坪Ｑ笪⑸镔Y源瓶頸奠定了堅實基礎。
（4）海洋“中光層”生物新資源探索。作為我國首位下潛深度達到100米的國際認證科學潛水員，于2019年牽頭建立了國內(nèi)首個海洋“中光層”（深度30-150米，占海洋生物多樣性80%以上）科學潛水團隊，率先在我國西沙群島和菲律賓Apo Reef（與菲律賓大學合作）等海域啟動了海洋“中光層”生物資源探索與系統(tǒng)挖掘工作，已采集中光層海綿、軟珊瑚、柳珊瑚等30余種，設計運用新型微生物培養(yǎng)技術(shù)“連續(xù)流生物反應器”，實現(xiàn)了海綿共附生“難培養(yǎng)”微生物的實驗室高效培養(yǎng)，已發(fā)現(xiàn)微生物新種50余個。探索和構(gòu)建海洋“中光層”生物資源庫對我國海洋生物學研究具有戰(zhàn)略意義。
1. Weiyan Zhang, Can Chen, Ye Yuan, Dengquan Su, Lijian Ding, Slava S Epstein*,Shan He*.Pararhodobacter marinussp. nov., a bacterium isolated from marine sediment in the East China Sea and emended description of the genus Pararhodobacter.International Journal of Systematic and Evolutionary Microbiology2019,69, 3293u20133298.
2. Ning Wang, Panpan Qiu, Wei Cui, Xiaojun Yan, Bin Zhang*,Shan He*. Recent Advances in Multi-target Anti-Alzheimer Disease Compounds (2013 Up to the Present).Current Medicinal Chemistry2019,26, accepted.
3. Lijian Ding, Lu Ren, Shuang Li, Jingjing Song, Zhiwen Han,Shan He*, Shihai Xu*. Production of New Antibiotic 4-Hydroxy-α-Pyrones by a Marine FungusAspergillus nigerCultivated in Solid Medium.Marine Drugs2019,17, 344.
4. Xiaoping He, Lijian Ding*, Mengqi Yi, Jianzhou Xu, Xuezhen Zhou, Weiyang Zhang,Shan He*. Separation of five diketopiperazines from the marine fungusAlternaria alternateHK-25 by high-speed counter-current chromatography.Journal of Separation Science2019,42, 2510u20132516.
5. Liming Huang, Lijian Ding*, Xiaohui Li, Ning Wang, Yushan Yan, Mengxiang Yang, Wei Cui, C. Benjamin Naman, Kejun Cheng, Weiyan Zhang, Bin Zhang, Haixiao Jin,Shan He*. A new lateral root growth inhibitor from the sponge-derived fungusAspergillussp. LS45.Bioorganic & Medicinal Chemistry Letters2019,29, 1593u20131596.
6. Lijian Ding*, Te Li, Xiaojian Liao,Shan He*, Shihai Xu*. Asperitaconic acids Au2013C, antibacterial itaconic acid derivatives produced by a marine-derived fungus of the genusAspergillus.The Journal of Antibiotics2018,71, 902-904.
7. Weiyan Zhang, Ye Yuan, Dengquan Su, Lijian Ding, Xiaojun Yan, Min Wu, Slava S. Epstein*,Shan He*.Saccharospirillum mangrovisp. nov., a bacterium isolated from mangrove sediment.International Journal of Systematic and Evolutionary Microbiology2018,68, 2813-2818.
8. Jialing Wang, Jiachen Zheng, Chunhui Huang, Jiaying Zhao, Jiajia Lin, Xuezhen Zhou, C. Benjamin Naman, Ning Wang, William H. Gerwick, Qinwen Wang, Xiaojun Yan, Wei Cui*,Shan He*. Eckmaxol, a Phlorotannin Extracted fromEcklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β.ACS Chemical Neuroscience2018,9, 1349?1356.
9. Yong Liu, Xuezhen Zhou, C. Benjamin Naman, Yanbin Lu, Lijian Ding*,Shan He*. Preparative Separation and Purification of Trichothecene Mycotoxins from the Marine FungusFusariumsp. LS68 by High-Speed Countercurrent Chromatography in Stepwise Elution Mode.Marine Drugs2018,16, 73.
10. Jiajia Lin, Jie Yu, Jiaying Zhao, Ke Zhang, Jiachen Zheng, Jialing Wang, Chunhui Huang, Jingrong Zhang, Xiaojun Yan, William H. Gerwick, Qinwen Wang, Wei Cui*,Shan He*. Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells.Oxidative Medicine and Cellular Longevity2017,2017, 6792543.
11. Fang Fang, Jiaying Zhao, Lijian Ding, Chunhui Huang, C. Benjamin Naman,Shan He*, Bin Wu , Peng Zhu, Qijun Luo, William H. Gerwick, Xiaojun Yan, Qinwen Wang, Zaijun Zhang, Wei Cui*. 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived FungusTrichodermasp. HPQJ-34.Marine Drugs2017,15, 260.
12. Pengjie Cai,Shan He*, Chengxu Zhou, Allen R. Place, Saddef Haq, Lijian Ding, Haimin Chen, Ying Jiang, Cheng Guo, Yaru Xu, Jinrong Zhang, Xiaojun Yan*. Two new karlotoxins found inKarlodinium veneficum(strain GM2) from the East China Sea.Harmful Algae2016,58, 66u201373.
13. Jiajia Lin, Ling Huang, Jie Yu, Siying Xiang, Jialing Wang, Jinrong Zhang, Xiaojun Yan, Wei Cui*,Shan He*, Qinwen Wang*. Fucoxanthin, a Marine Carotenoid, Reverses Scopolamine-Induced Cognitive Impairments in Mice and Inhibits Acetylcholinesterasein Vitro.Marine Drugs2016,14, 67.
14. Binbin Gu, Yanying Zhang, Lijian Ding,Shan He*, Bin Wu, Junde Dong, Peng Zhu, Juanjuan Chen, Jinrong Zhang, Xiaojun Yan*. Preparative Separation of Sulfur-Containing Diketopiperazines from Marine FungusCladosporiumsp. Using High-Speed Counter-Current Chromatography in Stepwise Elution Mode.Marine Drugs2015,13, 354-365.
15. Lijian Ding,Shan He*, Xiaojun Yan*. Efficient preparation of pseudoalteromone A from marinePseudoalteromonas rubraQD1-2 by combination of response surface methodology and high-speed counter-current chromatography: a comparison with high-performance liquid chromatography.Applied Microbiology and Biotechnology2014,98, 4369-4377.
16. Binbin Gu,Shan He*, Xiaojun Yan, Lixin Zhang*. Tentative biosynthetic pathways of some microbial diketopiperazines.Applied Microbiology and Biotechnology2013,97, 8439u20138453.
17.Shan He*, Xiaojun Yan*. From Resveratrol to Its Derivatives: New Sources of Natural Antioxidant.Current Medicinal Chemistry2013,20, 1005-1017.
18.Shan He, Hongqiang Wang, Peng Zhu, Juanjuan Chen, Rui Yang, Xiaojun Yan*. Preparative Isolation and Purification of Macrolactin Antibiotics from Marine BacteriumBacillus amyloliquefaciensusing High-Speed Counter-Current Chromatography in Stepwise Elution Mode.Journal of Chromatography A2013,1272, 15-19.
19.Shan He, Liyan Jiang, Bin Wu, Chang Li, Yuanjiang Pan*. Chunganenol: An Unusual Antioxidative Resveratrol Hexamer fromVitis chunganensis.Journal of Organic Chemistry2009,74, 7966-7969.
20.Shan He, Liyan Jiang, Bin Wu, Yuanjiang Pan, Cuirong Sun*. Pallidol, a resveratrol dimer from red wine, is a selective singlet oxygen quencher.Biochemical and Biophysical Research Communications2009,379, 283u2013287.
21.Shan He, Yanbin Lu, Liyan Jiang, Bin Wu, Feiying Zhang, Yuanjiang Pan*. Preparative isolation and purification of antioxidative stilbene oligomers fromVitis chunganensisusing high-speed counter-current chromatography in stepwise elution mode.Journal of Separation Science2009,32, 2339-2345.
22.Shan He, Bin Wu, Yuanjiang Pan*, Liyan Jiang. Stilbene Oligomers fromParthenocissus laetevirens: Isolation, Biomimetic Synthesis, Absolute Configuration and Implication of Antioxidative Defense System in the Plant.Journal of Organic Chemistry2008,73, 5233-5241.
23.Shan He, Cuirong Sun, Yuanjiang Pan*. Red Wine Polyphenols for Cancer Prevention.International Journal of Molecular Sciences2008,9, 842- 853.
24.Shan He, Yanbin Lu, Bin Wu, Yuanjiang Pan*. Isolation and purification of antioxidative isomeric polyphenols from the roots ofParthenocissus laetevirensby counter-current chromatography.Journal of Chromatography A2007,1151, 175- 179.
榮譽獎項
獲2012－2013年度寧波市優(yōu)秀博士后榮譽稱號；
獲2018年寧波市科學技術(shù)獎二等獎（排名第一）；
獲2019年浙江省自然科學獎二等獎（排名第一）。
科研項目
1. 國家自然科學基金(NSFC)面上項目，基于iChip技術(shù)的海洋“未培養(yǎng)”微生物資源挖掘及新天然產(chǎn)物發(fā)現(xiàn)Resource mining of marine "uncultured" microbes by iChip and new natural products discovery（41776168），2018.01-2021.12
2. 國家自然科學基金(NSFC)青年項目，海洋Uncultured 放線菌資源挖掘及新天然產(chǎn)物發(fā)現(xiàn)Resource Mining of Marine Uncultured Actinomycetes and Discovery of New Natural Products（41306134），2014.01-2016.12
3. 國家外專局/教育部111計劃，海洋生物醫(yī)藥創(chuàng)新引智基地（D16013），2016.08-2021.08
4. 國家科技部(MOST)重點研發(fā)計劃項目子課題，深海多孔動物門藥物先導化合物的高效篩選與發(fā)現(xiàn)（2018YFC0310902），2018.08-2021.12
5. 國家科技部(MOST)星火計劃，褐藻多酚作為大黃魚飼料添加劑的應用與推廣（2013GA701024），2013.01-2014.12
6. 教育部(MOE)博士點基金，卡羅藻毒素高效制備及其在養(yǎng)殖水域中的快速檢測新方法研究（20133305120007），2014.01-2016.12
7. 浙江省自然科學基金(Zhejiang NSF)，基于高速逆流色譜的卡羅藻毒素高效制備及新天然產(chǎn)物發(fā)現(xiàn)（LQ13B020004），2013.01-2015.12
8. 浙江省科技廳(Science Technology Department of Zhejiang Province)錢江人才計劃，通過氧化脅迫葡萄科植物產(chǎn)生新型抗腦卒中先導化合物的研究（2012R10068），2012.08-2013.12
9. 浙江省科技廳(Science Technology Department of Zhejiang Province)重點科技創(chuàng)新團隊子課題，海洋藍細菌中新型抗腫瘤藥物的開發(fā)（2012R10029-2），2011.04-2014.06
10. 寧波市科技局(Science Technology Department of Ningbo City)富民項目，海洋抗菌微生物產(chǎn)業(yè)化研究及其在大黃魚養(yǎng)殖中的應用示范（2017C10016），2017.01-2019.12
11. 寧波市自然科學基金(Ningbo NSF)，白藜蘆醇低聚體生物合成誘導及聚合度與神經(jīng)保護的構(gòu)效研究（2013A610278），2013.02-2015.01
12. 寧波市海洋局(Marine Department of Ningbo City)海洋經(jīng)濟創(chuàng)新發(fā)展示范項目，寧波海洋生物高值利用公共服務平臺-寧波海洋微生物資源開發(fā)利用子平臺（NBHY-2017-P2），2018.03-2020.12
13. 寧波市科技局(Science Technology Department of Ningbo City)，寧波市海洋生物產(chǎn)業(yè)調(diào)研，2016.11-2017.06
