教育經(jīng)歷
1998/10u20132000/03 加拿大多倫多大學(xué)神經(jīng)科學(xué)系，高級博士后
1996/10u20131998/01 加拿大多倫多大學(xué)神經(jīng)科學(xué)系，博士后
1993/10u20131996/10 香港大學(xué)醫(yī)學(xué)院生理系，博士
1988/09u20131990/07 第三軍醫(yī)大學(xué)外科系，碩士
1979/09u20131984/07 第三軍醫(yī)大學(xué)醫(yī)學(xué)系，學(xué)士
工作經(jīng)歷與任職
2017/08u2013至今 青島大學(xué)神經(jīng)再生與康復(fù)研究院院長、醫(yī)學(xué)部常務(wù)副部長
2013/01u20132017/08 武漢大學(xué)醫(yī)學(xué)部教授、醫(yī)學(xué)部副部長
2008/04u20132012/12 內(nèi)華達(dá)大學(xué)醫(yī)學(xué)院生理和細(xì)胞生物學(xué)系tenure終身教職
2006/04u20132008/03 加拿大多倫多大學(xué)西方研究所資深科學(xué)家
2000/04u20132006/03 加拿大多倫多大學(xué)西方研究所資深科學(xué)家；加拿大多倫多大學(xué)生理學(xué)系助理教授
1984/08u20131988/08 第三軍醫(yī)大學(xué)外科研究所 : 助理研究員
榮譽(yù)稱號
中國國家自然科學(xué)基金委"海外杰出青年"
加拿大國家醫(yī)學(xué)基金會(huì)"Scholarship 獎(jiǎng)"
加拿大國家心臟和中風(fēng)基金會(huì)"Scholarship獎(jiǎng)"
湖北省“百人計(jì)劃”特聘專家
湖北省“醫(yī)學(xué)領(lǐng)軍人才”
武漢東湖高新“3551”人才基金
社會(huì)兼職
國家自然科學(xué)基金會(huì)“優(yōu)青”醫(yī)學(xué)組二審組長
國家自然科學(xué)基金會(huì)“神經(jīng)科學(xué)組”二審組長
“國家重點(diǎn)研發(fā)計(jì)劃干細(xì)胞及轉(zhuǎn)化研究專項(xiàng)”終審評委專家
“教育部科技獎(jiǎng)”終審評委專家
“工信部人工智能產(chǎn)業(yè)創(chuàng)新重點(diǎn)任務(wù)揭榜項(xiàng)目”終審評委專家
“華夏醫(yī)學(xué)科技獎(jiǎng)”終審評委專家
中國醫(yī)療保健國際交流促進(jìn)會(huì)常務(wù)理事
中國研究型醫(yī)院學(xué)會(huì)生物治療專業(yè)委員會(huì)委員
中國國際神經(jīng)外科協(xié)會(huì)委員
湖北省醫(yī)學(xué)會(huì)醫(yī)學(xué)科研管理分會(huì)副主任委員
承擔(dān)項(xiàng)目課題情況
研究工作多次受到美國、加拿大、中國政府研究機(jī)構(gòu)的資助，主持和參與中、美、加國家級課題 16 項(xiàng)、省部級課題 6 項(xiàng)
創(chuàng)新成就
基礎(chǔ)研究：發(fā)表SCI論文70余篇：在 Nature, Nature Medicine, Nature Neuroscience等國際頂級SCI期刊發(fā)表論文5篇，單篇最高引用400余次。
轉(zhuǎn)化應(yīng)用研究：申請發(fā)明專利 9 項(xiàng)，授權(quán) 7 項(xiàng)
代表性論文
1.Wan Q,Xiong ZG, Man HY, Ackerley CA, Braunton J, Lu WY, Becker LE, MacDonald JF, Wang YT: Recruitment of functional GABAAreceptors to postsynaptic domains by insulin.Nature.1997; 388:686-690
2.Wan Q,Man HY, Liu F, Braunton J, Niznik HB, Pang SF, Brown GM, Wang YT: Differential modulation of GABAAreceptor function by MEL1aand MEL1breceptors.Nature Neuroscience. 1999; 2(5): 401-403
3. Liu F,Wan Q,Pristupa ZB, Yu XM, Wang YT, Niznik HB: Direct protein-protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors.Nature. 2000; 403:274-280
4. Ning K, Li L, Liao M, Liu B, Mielke JG, Chen Y, Duan Y, El-Hayek YH,Wan Q*: Circadian regulation of GABA(A) receptor function by CKIepsilon-CKIdelta in the rat suprachiasmatic nuclei.Nature Neuroscience.2004; 7(5):489-490
5. Ning K, Pei L, Liao M, Liu B, Zhang Y, Jiang W, Mielke JG, Li L, Chen Y, El-Hayek YH, Fehlings MG, Zhang X, Liu F, Eubanks J,Wan Q*:Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.Journal of Neuroscience.2004; 24(16):4052-60
6. Liu B, Liao M, Mielke JG, Li L, Chen Y, Ning K, El-Hayek YH, Zukin RS, Fehlings MG,Wan Q*: Ischemic insults direct GluR2-lacking AMPA receptors to synaptic sites.Journal of Neuroscience,2006; 26(20):5309-19
7. Chang N, El-Hayek YH, Gomez E andWan Q*: Phosphatase PTEN in neuronal injury and brain disorders.Trends in Neurosciences2007; 30(11): 581-586
8. Li L andWan Q*: rSac3, a new member of Sac domain phosphoinositide phosphatases family.Cell Research2007; 17:1-3
9. Li L, El-Hayek YH, Liu BS, Chen Y, Gomez E, Wu XH, Ning K, Li LJ, Chang C, Zhang L, Wang ZG, Hu X,Wan Q*: Direct-current Electrical Field Guides Neural Stem/progenitor Cell Migration.Stem Cells2008; 26(7): 1610-1836
10. Liu B, Li L, Zhang Q, Chang N, Wang D, Shan Y, Li L, Wang H, Feng H, Zhang L, Brann DW andWan Q*: Preservation of GABAAreceptor function by PTEN inhibition protects against neuronal death in ischemic stroke.Stroke2010; 41(5):1018-26
11. Cheung CC, Yang C, Berger T, Zaugg K, Reilly P, Elia AJ, Wakeham A, You-Ten A, Chang N, Li LJ,Wan Q, and Mak TW: Identification of BERP (brain-expressed Ring finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA-A receptors.Proc Natl Acad Sci U S A.2010; 107(26):11883-8
12. Chang N, Li L, Hu R, Shan Y, Liu B, Li L, Wang H, Feng H, Wang D, Cheung CC, Liao M andWan Q*: Differential regulation of NMDA receptor function by DJ-1 and PINK1.Aging Cell. 2010; 9:837u2013850
13. Hu R, Duan B, Wang D, Yu Y, Li W, Luo H, Lu P, Lin J, Zhu G,Wan Qand Feng H: Role of acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury.Annals of Surgery2011;254:1u201310
14. Zheng M, Liao M, Cui T, Fan DS, andWan Q*: Regulation of nuclear TDP-43 by NR2A-containing NMDA receptor and phosphatase PTEN.J Cell Science2012; 125:1556-67
15. Hu R, Sun H, Zhang Q, Chen J, Wu N, Meng H, Cui G, Hu S, Li F, Lin J,Wan Q, Feng H. G-protein coupled estrogen receptor 1 mediated estrogenic neuroprotection against spinal cord injury.Crit Care Med2012;40(12):3230.
16. Chen J, Zhuang Y, Zhang ZF, Wang S, Jin P, He C, Hu PC, Wang ZF, Li ZQ, Xia GM, Li G, Wang Y,Wan Q*. Glycine confers neuroprotection through microRNA-301a/PTEN signaling.MolecularBrain.2016; 26; 9(1):59.
17. Hu R, Chen J, Lujan B, Lei R, Zhang M, Wang Z, Liao M, Li Z, Wan Y, Liu F, Feng H,Wan Q*. Glycine triggers a non-ionotropic activity of GluN2A-containing NMDA receptors to confer neuroprotection.ScientificReports.2016; 6:34459
18. Li LJ, Hu R, Lujan B, Chen J, Zhang JJ, Nakano Y, Cui TY, Liao M, Chen JC, Man H, Feng H,Wan Q*. Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-containing NMDA Receptors.Frontiers in Molecular Neuroscience.2016; 9:102.
19. Zhang X, Chen XP, Lin JB, Xiong Y, Liao WJ,Wan Q*. Effect of enriched environment on angiogenesis and neurological functions in rats with focal cerebral ischemia.Brain Research.2017; 1655:176-185
20. Zhang ZF, Chen J, Han X, Zhang Y, Liao HB, Lei RX, Zhuang Y, Wang ZF, Li Z, Chen JC, Liao WJ, Zhou HB, Liu F,Wan Q*. Bisperoxovandium (pyridin-2-squaramide) Targets Both PTEN and Erk1/2 to Confer Neuroprotection.British Journal of Pharmacology2017; 174(8):641u2013656.
21. Lei Y, Zhang ZF, Lei RX, Wang S, Zhuang Y, Liu AC, Wu Y, Chen J, Tang JC, Pan MX, Liu R, Liao WJ, Feng YG,Wan Q*, Zheng M*. DJ-1 Suppresses Cytoplasmic TDP-43 Aggregation in Oxidative Stress-Induced Cell Injury.J Alzheimers Dis. 2018. doi: 10.3233/JAD-180460
22. Liu R, Liao XY, Pan MX, Tang JC, Chen SF, Zhang Y, Lu PX, Lu LJ, Zou YY, Qin XP, Bu LH,Wan Q*. Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-κB p65/Hif-1α Signaling Pathway.J Immunol.2019;202(6):1704-1714
23. Cui Y,Wan Q*. NKT Cells in Neurological Diseases.Front. Cell. Neurosci.,2019: 13:245
24. Liu R, Liao XY, Tang JC, Pan MX, Chen SF, Lu PX, Lu LJ, Zhang ZF, Zou YY, Bu LH, Qin XP,Wan Q*. BpV(pic) confers neuroprotection by inhibiting M1 microglial polarization and MCP-1 expression in rat traumatic brain injury.Mol Immunol.2019;112:30-39
25. Liao XY, Lei Y, Chen SF, Cheng J, Zhao D, Zhang ZF, Han X, Zhang Y, Liao HB, Zhuang Y, Chen J, Zhou HBWan Q*, Zhou YY*. The neuroprotective effect of bisperoxovandium (pyridin-2-squaramide) in intracerebral hemorrhage.Drug Design, Development and Therapy.2019:13: 1957u20131967
26. Zhao D, Qin XP, Chen SF, Liao XY, Cheng J, Liu R, Lei Y, Zhang ZF,Wan Q*. PTEN inhibition Protects Against Experimental Intracerebral Hemorrhage-Induced Brain Injury through PTEN/E2F1/β-catenin pathway.Front. Mol. Neurosci.,2019
