個(gè)人簡(jiǎn)介
婁智勇，男，1980年出生于天津，清華大學(xué)副教授。2002年獲清華大學(xué)基礎(chǔ)科學(xué)理學(xué)學(xué)士學(xué)位，2007年獲清華大學(xué)生物學(xué)理學(xué)博士學(xué)位，2007年留校任清華大學(xué)醫(yī)學(xué)院講師，2010年12月任清華大學(xué)醫(yī)學(xué)院副教授，婁智勇曾獲2006年清華大學(xué)醫(yī)學(xué)院學(xué)術(shù)新秀，2007年清華大學(xué)研究生“航天海鷹”學(xué)術(shù)新秀，2010年SCOPUS青年科學(xué)家新人獎(jiǎng)等榮譽(yù)。
研究方向
利用蛋白質(zhì)晶體學(xué)，進(jìn)行重要致病微生物（禽流感病毒、乙丙型肝炎病毒、SARS冠狀病毒、結(jié)核桿菌、EV71病毒、NDM-1“超級(jí)細(xì)菌”等）及與人類疾病相關(guān)蛋白質(zhì)的結(jié)構(gòu)與功能研究，以及基于結(jié)構(gòu)的藥物篩選工作。
代表性論文
1. Crystal Structure of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis. Shan S, Chen X, Liu T, Zhao H, Rao Z and Lou Z*. FASEB J. 2011 Jan 31. [Epub ahead of print] (Corresponding author)
2. The crystal structure of porcine reproductive and respiratory syndrome virus nonstructural protein Nsp1beta reveals a novel metal-dependent nuclease. Xue F, Sun Y, Yan L, Zhao C, Chen J, Bartlam M, Li X, Lou Z*, Rao Z.J Virol. 2010 Jul;84(13):6461-71. (Corresponding author)
3. Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Yuan P, Bartlam M, Lou Z, Chen S, Zhou J, He X, Lv Z, Ge R, Li X, Deng T, Fodor E, Rao Z, Liu Y. Nature. 2009 Apr 16; 458(7240):909-13. (co-first author)
4. Crystal Structure of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Leader Protease Nsp1α. Sun Y, Xue F, Guo Y, Ma M, Hao N, Zhang XC, Lou Z*, Li X, Rao Z. J Virol. 2009 Aug 12. (Corresponding author)
5. C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer. Zhong N, Zhang S, Xue F, Kang X, Zou P, Chen J, Liang C, Rao Z, Jin C, Lou Z*, Xia B. Protein Sci. 2009 Apr;18(4):839-44. (Corresponding author)
6. Structural basis for the recognition of blood group trisaccharides by norovirus. Cao S, Lou Z, Tan M, Chen Y, Liu Y, Zhang Z, Zhang XC, Jiang X, Li X, Rao Z. J Virol. 2007 Jun;81(11):5949-57. (co-first author)
7. Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10. Su D, Lou Z, Sun F, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z. J Virol. 2006 Aug;80(16):7902-8. (co-first author)
8. Crystal structure of human pyrroline-5-carboxylate reductase. Meng Z, Lou Z, Liu Z, Li M, Zhao X, Bartlam M, Rao Z. J Mol Biol. 2006 Jun 23;359(5):1364-77. (co-first author)
9. Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core. Xu Y, Lou Z, Liu Y, Pang H, Tien P, Gao GF, Rao Z. J Biol Chem. 2004 Nov 19;279(47):49414-9. (co-first author)
10. Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase complexed with a novel natural tri-peptide inhibitor from venom of Agkistrodon acutus. Lou Z, Hou J, Liang X, Chen J, Qiu P, Liu Y, Li M, Rao Z, Yan G. J Struct Biol. 2005 Dec;152(3):195-203.
11. Crystal structures of Nipah and Hendra virus fusion core proteins. Lou Z, Xu Y, Xiang K, Su N, Qin L, Li X, Gao GF, Bartlam M, Rao Z. FEBS J. 2006 Oct;273(19):4538-47.
