人物經(jīng)歷
2006年本科畢業(yè)于蘭州大學(xué)化學(xué)化工學(xué)院；2011年6月博士畢業(yè)于蘭州大學(xué)化學(xué)化工學(xué)院；2009年9月至2011年4月在美國肯塔基大學(xué)藥學(xué)院聯(lián)合培養(yǎng)。2011年7月進(jìn)入西北農(nóng)林科技大學(xué)生命科學(xué)學(xué)院工作。中國化學(xué)會會員。開設(shè)課程
承擔(dān)本科生《生物信息學(xué)》、《生物信息學(xué)綜合實(shí)驗(yàn)》，參與研究生《生物信息學(xué)研究進(jìn)展》課程教學(xué)工作。研究方向
植物激素類似物的計(jì)算機(jī)輔助分子設(shè)計(jì)；化學(xué)小分子對植物生長及逆境響應(yīng)的調(diào)控。科研項(xiàng)目
國家自然科學(xué)基金青年基金，基于靶標(biāo)BRI1的新型油菜素內(nèi)酯受體激動劑的合理設(shè)計(jì)（21302153，2014-2016）；陜西省自然科學(xué)基金青年項(xiàng)目，油菜素甾醇類植物激素類似物的虛擬篩選研究及生物活性評價(jià)（2017JQ3003，2017-2018）；中央高�；究蒲袠I(yè)務(wù)費(fèi)青年培育項(xiàng)目，基于藥效團(tuán)的BRI1激動劑的虛擬篩選及活性評價(jià)（2015）；發(fā)表論文
Lei, B. L., Heng, NJ, Dang, XX, Liu, J. Y., Yao, X. J and Zhang CL*. Structure based in silico identification of potentially non-steroidal brassinosteroids mimics. Molecular Biosystems, 2017. 13(7): p.1364-1369.Lei, B. L.*, Liu, J. Y., and Yao, X. J. Unveiling the molecular mechanism of brassinosteroids: Insights from structure-based molecular modeling studies . Steroids, 2015. 104: p. 111-117.Lei, B. L.*, Li, J. Z., and Yao, X. J., A Novel Strategy of Structural Similarity Based Consensus Modeling. Molecular Informatics, 2013. 32(7): p. 599-608.Lei, B. L., Adel, H. and Zhan, C.-G.*, Structural features and binding free energies for non-covalent inhibitors interacting with immunoproteasome by molecular modeling and dynamics simulations. Theoretical Chemistry Accounts, 2012. 131(4): p. 1203-1213.Wei, D. H., Lei, B. L., Tang M. S., and Zhan C.-G.*, Fundamental Reaction Pathway and Free Energy Profile for Inhibition of Proteasome by Epoxomicin , Journal of the American Chemical Society, 2012. 134(25): p. 10436-10450.Lei, B. L., Hameed, Mdma, Hamza, A., Wehenkel, M., Muzyka, J. L., Yao, X. J., Kim, K. B., and Zhan, C. G.*, Molecular Basis of the Selectivity of the Immunoproteasome Catalytic Subunit LMP2-Specific Inhibitor Revealed by Molecular Modeling and Dynamics Simulations. Journal of Physical Chemistry B, 2010. 114(38): p. 12333-12339.Lei, B. L., Ma, Y. M., Li, J. Z., Liu, H. X., Yao, X. J.*, and Gramatica, P., Prediction of the adsorption capability onto activated carbon of a large data set of chemicals by local lazy regression method. Atmospheric Environment, 2010. 44(25): p. 2954-2960.Lei, B. L., Li, J. Z., Lu, J., Du, J., Liu, H. X., and Yao, X. J.*, Rational Prediction of the Herbicidal Activities of Novel Protoporphyrinogen Oxidase Inhibitors by Quantitative Structure-Activity Relationship Model Based on Docking-Guided Active Conformation. Journal of Agricultural and Food Chemistry, 2009. 57(20): p. 9593-9598.Lei, B. L., Li, S. Y., Xi, L. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Novel approaches for retention time prediction of oligonucleotides in ion-pair reversed-phase high-performance liquid chromatography. Journal of Chromatography A, 2009. 1216(20): p. 4434-4439.Lei, B. L., Xi, L. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Global, local and novel consensus quantitative structure-activity relationship studies of 4-(Phenylaminomethylene) isoquinoline-1, 3 (2H, 4H)-diones as potent inhibitors of the cyclin-dependent kinase 4. Analytica Chimica Acta, 2009. 644(1-2): p. 17-24.Lei, B. L., Du, J., Li, S. Y., Liu, H. X., Ren, Y. Y., and Yao, X. J.*, Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of thiazolone derivatives as hepatitis C virus NS5B polymerase allosteric inhibitors. Journal of Computer-Aided Molecular Design, 2008. 22(10): p. 711-725.Lei, B. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Accurate prediction of aquatic toxicity of aromatic compounds based on Genetic Algorithm and Least Squares Support Vector Machines. Qsar & Combinatorial Science, 2008. 27(7): p. 850-865.
