教師簡介
沈秉謙,1980-84年就讀于華東理工大學(xué)生物化學(xué)專業(yè),1987年獲得澳洲新南威爾士大學(xué)(University of New South Wales)生物工程碩士,1991年獲得昆士蘭大學(xué)(University of Queensland)化學(xué)工程博士;1991-93年在密歇根大學(xué)(University of Michigan)化學(xué)工程系從事博士后研究工作,參與了第一個干細(xì)胞生物反應(yīng)器原型設(shè)計工作,也是最早從事基因治療反轉(zhuǎn)錄病毒生產(chǎn)工藝開發(fā)的人員。1993-94年就職于生物技術(shù)公司Progenitor, Inc. (Scientist);1994-98年就職于生物技術(shù)公司Metabolex, Inc. (Group Leader);1998-2001年就職于Monsanto Co. (Senior Scientist)。在若干生物醫(yī)藥領(lǐng)域,如動物細(xì)胞培養(yǎng)、干細(xì)胞/組織工程、基因治療、生物材料、納米給藥系統(tǒng)、藥物篩選模型、生物檢測等,積累了比較豐富的技術(shù)研發(fā)和項目管理經(jīng)驗,有些工作屬于首創(chuàng)。按照中國科學(xué)院“引進國外杰出人才計劃”,2001-08年任上海生命科學(xué)研究院研究員,中國科學(xué)院研究生院教授。2008年7月加入南開大學(xué)。
代表性論文
1.Bing Q. Shen, Steve Reid, Paul F. Greenfield (1992). Continuous monoclonal antibody production by a composite gel perfusion bioreactor in a protein-free medium, Animal Cell Technology: Basic & Applied Aspects, 4: 173-178.
2.Bing Q. Shen, Paul F. Greenfield, Steve Reid (1993). Examination of polysaccharides for their uses in hybridoma cell culture, Biotechnology Techniques, 7(3): 193-198.
3.Bing Q. Shen, Paul F. Greenfield, Steve Reid(1994). Calcium alginate immobilized hybridomas grown using a fluidized-bed perfusion system with a protein-free medium, Cytotechnology, 14: 109-117.
4.Bing Q. Shen, Paul F. Greenfield, Steve Reid (1994). Hybridoma cells in a protein-free medium within a composite gel perfusion bioreactor, Cytotechnology, 16: 51-58.
5. Bernhard O. Palsson,Bing Q. Shen, Mark E. Meyeroff, Marek Trojanowicz (1994). Simultaneous determination of ammonia nitrogen and L-glutamine in bioreactor media by flow injection analysis, Analyst, 118: 1361-1365.
6.Bing Q. Shen, Michael F. Clarke, Bernhard O. Palsson (1996). Kinetics of retroviral production from the amphotrophic ψCRIP murine producer cell line, Cytotechnology, 22: 185-195.
7. Xianghui Gong, Qiangyi Fang, Xuesen Li, Xiangzong Han, Yuyin Wu, Shengli Yang,Bing Q. Shen(2005). A high-throughput end-point assay for viable mammalian cells, Cytotechnology, 49: 51-58.
8. Xianghui Gong, Dongxiao Li, Xiangzong Han, Qiangyi Fang, Yuyin Wu, Shengli Yang,Bing Q. Shen(2006). Fed-batch culture optimization of a growth-associated hybridoma cell line, Cytotechnology, 52: 25-38.
9. Xiangzong Han, Lei Sun, Dongxiao Li, Qiangyi Fang, Shengli Yang,Bing Q. Shen(2007). Transient expression of osteopontin in HEK293 cells in serum-free culture, Enzyme & Microbial Technology, 41: 133-140.
專利授權(quán)
10.沈秉謙,朱蕾,呼吸到插管裝置,ZL032315902
11.沈秉謙,生物多糖微膠囊及其制備方法和用途
12.沈秉謙,貢向輝,楊勝利,高通量哺乳動物細(xì)胞培養(yǎng)基優(yōu)化方法,中國專利申請?zhí)枺ㄒ压_)
13.沈秉謙,楊勝利,高通量細(xì)胞分離裝置與使用方法,中國專利申請?zhí)枺ㄒ压_)
14.沈秉謙,楊勝利,方強毅,一種哺乳動物細(xì)胞無血清培養(yǎng)基,中國專利申請?zhí)枺ㄒ压_)
15.沈秉謙,楊勝利,海藻酸鹽納米膠囊及其制備方法,中國專利申請?zhí)枺ㄒ压_)
16.Shen, Bingqian& YANG Shengli, Composition and method for preparing alginate nanocapsules, US Application No. 11/368743, filing date March 06, 2006.