1987年，武漢大學(xué)化學(xué)系，獲理學(xué)學(xué)士學(xué)位；

1990年，武漢大學(xué)化學(xué)系，獲理學(xué)碩士學(xué)位。之后在云南省化工研究院工作，從事天然香料等半合成研究；

1993年，中國科學(xué)院昆明植物研究所，獲理學(xué)博士學(xué)位。師承周俊院士，并拜師香港科技大學(xué)戴偉民教授及昆明植物所郝小江教授學(xué)習(xí)手性催化劑的設(shè)計(jì)與合成；

1998年，前往美國密西西比州立大學(xué)學(xué)習(xí)工作，并獲得Assistant Research Professor；

2003年，獲得中科院“國外杰出人才”；

2005年，到美國Virginia Tech （美國弗吉尼亞理工大學(xué)）做高級(jí)訪問學(xué)者；

2011年至今，作為高層人才到河北大學(xué)工作。

圍繞有機(jī)小分子的立體化學(xué)，尤其是天然產(chǎn)物的立體化學(xué)開展實(shí)驗(yàn)與理論相結(jié)合的多學(xué)科交叉創(chuàng)新研究。

《有機(jī)立體化學(xué)》、《天然產(chǎn)物化學(xué)》、《藥物化學(xué)》。

1.主持：手性催化劑的構(gòu)象對(duì)對(duì)映加成反應(yīng)選擇性的影響，國家基金委“主任專項(xiàng)”。

2.主持：八種藏藥材資源調(diào)查與評(píng)價(jià)、化學(xué)成分分析，中國科學(xué)院重點(diǎn)項(xiàng)目

3.主持：天然產(chǎn)物化學(xué)中的應(yīng)用計(jì)算化學(xué)研究，國家基金委基金

4.主持：手性噁唑烷的設(shè)計(jì)、合成及其在中樞神經(jīng)細(xì)胞保護(hù)中的活性研究，國家基金委基金

5.主持：中科院“國外杰出人才”基金。

6.主持：河北大學(xué)“高層引進(jìn)人才”基金。

7.主要參與人：中國特有植物和微生物藥用活性物質(zhì)的基礎(chǔ)研究，973項(xiàng)目中的子課題項(xiàng)目

8.主要參與人：教育部創(chuàng)新團(tuán)隊(duì)以及河北省“巨人計(jì)劃”。

1. Li Liu, Qing Yang, He Yu, Jing-Liang Li, Yu-Ning Pei, Hua-Jie Zhu,*Zhen-Qiu Li, Xiao-Ke Wang, “Fitness of Driving Force and Catalytic Space in Chiral Catalyst Design. Application of Axial Biscarboline N-O Chiral Catalysts for Enantioselective Allylation of Allyltrichlorosilane to Bulky Substituted Aldehydes”Tetrahedron. 2015,71, 3296-3302.

2. H. Yu, W-X Li,J.-C. Wang,Q. Yang, H.-J. Wang,C.-C. Zhang, S.-S. Ding, Y. Li,H.-J Zhu,* “Pestalotiopsin C, Stereochemistry of A New Caryophyllene from a Fungus ofTrichodermasp. and Its Tautomerization Characteristics in Solution”,Tetrahedron. 2015,71, 3491-3494.

3. D.-B. Hu, W.-X. Li, Z.-Z. Zhao, T. Feng, R.H. Yin, Z.-H. Li, J.-K. Liu, H. J. Zhu*. “Highly unsaturated pyranone derivatives from the basidiomycete Junghuhnianitida”Tetrahedron Lett.2014,55, 6530-6533.

4. Jin-Liang Li, Li Liu, Yu-Ning Pei, Hua-Jie Zhu*, “Copper(II)-containing C2-symmetric bistetracarboline amides in enantioselective Henry reactions”.Tetrahedron, 2014,70, 9077-9083.

5. Yu-NingPei, Yu Deng, Jing-Liang Li, Hua-Jie Zhu“Chiral BiscarbolineN,N’-Dioxide Derivatives Catalyzed Asymmetric Reduction of Ketoimines with Trichlorosilane”Tetrahedron Lett,2014.55, 2948-2952.

6. Bing Bai,Xing-Yao Li, Li Liu,Yan Li,Hua-Jie Zhu*, “Syntheses of Novelβ-Carboline Derivatives and the Activities against Five Tumor-Cell Lines” .Bioorg. Med. Chem. Lett.2014,24, 96u201398.

7. Ping He, Xiangfen Wang, Xiujie Guo, Chuanqi Zhou, Shigang Shen, Dongbao Hu, Xiaolong Yang, Duqiang Luo, Rina Dukor, Huajie Zhu* “Vibrational Circular Dichroism Study for Natural Schizandrin fromPyrola rotundifoliaL. and Reassignment of Its Absolute Configuration”,Tetrahedron Lett.2014, 55, 2965u20132968.

8. Hua-Jie Zhu,* Wen-Xin Li, Dong-Bao Hu, Meng-Liang Wen, “Discussion of Absolute Configuration for Bioactive Griseusins by Comparing Computed Optical Rotations and Electronic Circular Dichroism with the Experimental Results”Tetrahedron, 2014,70, 8236-8243.

9. Wei Pan, Dongbao Hu, He Yu, Huajie Zhu*, “Mechanism Investigation of Hydrosilylation of Ketimines with Trichlorosilane Using Asymmetric-Axle-Supported ChiralN-OAmides and Absolute Configuration Discussion forN-Substituted Aniline” ,Tetrahedron2014,69, 7253-7257

10.S. Zhang, D.-B. Hu, J.-B. He, K.-Y. Guan, H.-J. Zhu,* “A NovelTetrahydroquinoline Acid and Two NewBenzofuranones fromCapparis spinosaL., A Case Study of Absolute Configuration Determination Using Quantum Methods” ,Tetrahedron2014,70, 869-873

11. Jiang-Bo He, Yan-Nan Ji, Dong-Bao Hu, Shen Zhang, Hui Yan, Xin-Chun Liu, Huai-Rong Luo, Hua-Jie Zhu* “Structure and AbsoluteConfigurationofPenicilliumine, a New Alkaloid fromPenicillium commune366606”,TetrahedronLett.2014.55, 2684-2686.

12. W. Pan, Y. Deng, J.-B. He, B. Bai, H.-J. Zhu*, “Highly Efficient Asymmetric-Axle-Supported N-O Amides in EnantioselectiveHydrosilylation of Ketimines with Trichlorosilane”,Tetrahedron, 2013,69, 7253-.

13. B.-X. Zhao, Y. Wang, C. Li, G.-C. Wang, X.-J. Huang, C.-L. Fan, Q.-M. Li, H.-J. Zhu*, W.-M. Chen*, W.-C. Ye*, “Flueggedine, a novel axisymmetric indolizidine alkaloid dimer from Flueggea virosa”,Tetrahedron Lett. 2013,54, 4708-4711.

14.Y. Deng,W. Pan,Y.-N.Pei, J.-L. Li, X.-C. Liu H.-J. Zhu*, “Asymmetric Addition of Aldehydes with Allytrichlorosianes Catalyzed by AxialN-O Secondary Amides”Tetrahedron2013.69.10431-10437.

15. Q.-M. Li, J. Ren, L. Shen, B. Bai Q.-M. Li, X.-C. Liu and M.-L. Wen, H.-J. Zhu*, “Determining the Absolute Configuration of Benzopyrenomycin from Optical Rotation, Electronic Circular Dichroism and Population Analysis of Different Conformations via DFT Methods”.Tetrahedron2013,69,3067-3074.

16. J. Ren, G-L Li, L Shen, G-L Zhang, Larance Nafie, H-J Zhu,* “Challenges in the Assignment of Relative and Absolute Configurations of Complex Molecules”Tetrahedron.2013,69,10351-10356.

17. B-D. Zhou, J. Ren, X.-C. Liuand H.-J. Zhu* “Theoretical and Experimental Study of the Absolute Configuration of Helical Structure of (2R,3S)-Rubiginone A2 Analog”Tetrahedron.2013,69, 1189-1194.

18. B. Bai, H.-J. Zhu,*W. Pan,“Structure Influence of Chiral 1,1u2032-Biscarboline-N,Nu2032-Dioxide on the Enantioselective Allylation of Aldehydes with Allyltrichlorosilanes”Tetrahedron.2012.68, 6829-6836.

19. B. Bai, L. Shen, J. Ren, H. J. Zhu* “Chiral BiscarbolineN,N’-Dioxide Derivatives. Highly Enantioselective Addition of Allyltrichlorosilane to Aldehydes”Advanced Synthesis and Catalysts,2012,354, 354-358.

20. Z.-G. Ding, J.-Y. Zhao, M.-G. Li, R. Huang, Q.-M. Li, X.-L. Cui, H.-J. Zhu,* and M.-L. Wen* “Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species”J. Nat. Prod.2012,75, 1994?1998.

21. S.-D. Zhao, L. Shen, D.-Q. Luo, H.-J. Zhu* “Progresses in Computational Methods Used in Natural Product Chemistry”Cur. Org. Chem.2011,15, 1843.

22. X.-N. Li,Y. Zhang,X.-H. Cai, T. Feng, Y.-P. Liu, Y. Li,J. Ren,H.-J. Zhuand X.-D. Luo“Psychotripine: a Novel Trimeric Pyrroloindoline Derivative from Psychotria pilifera”O(jiān)rg. Lett. 2011,13, 5896-5899.

23. B. Bai,X.-Y. Li, Y. Li,H.-J. Zhu* “Design, Synthesis andCytotoxic Activities ofNovelβ- Amino Alcohol DerivativesBioorg. Med. Chem. Lett.2011,21, 2302-2304.

24. Z.-G. Ding,M.-G. Li,J. Ren,J.-Y. Zhao,R. Huang,Q.-Z. Wang,X.-L. Cui,H.-J. Zhu*and M.-L. Wen* “Phenazinolins Au2013E: novel diphenazines from a tin mine tailings-derivedStreptomycesspecie”O(jiān)rg. & Biomol. Chem.2011,9, 2771.

25. F. Wang, Y.Gao, L. Zhang, B. Bai, Y. N. Hu, Z. J. Dong, Q. W. Zhai, H.- J. Zhu,* J. K Liu,.* “A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity.”O(jiān)rg. Lett.2010,12, 3196-3199.

26. H-G. Ding, M.-G. Li, J.-Y. Zhao, J. Ren, R. Huang, M.-J. Xie, X.-L. Cui, H.-J. Zhu*, and M.-L. Wen* “Naphthospironone A, an Unprecedented Polycyclic Metabolite from an Alkaline Mine Waste Extremophile”.Chem.-A J. Eur. 2010,16, 3902 u2013 3905.

27. J. Ren,J.-X. Jiang, L.-B. Li,T.-G. Liao, R.-R. Tian, X.-L. Chen, S.-P. Jiang, C. U. Pittman, Jr. and H.-J. Zhu* “Assignment of Absolute Configuration ofConcentricolideand Absolute Configuration Determination of Its Bioactive Analogues Using DFT Methods.”Eur. J. Org. Chem. 2009. 3987-3991.

27. W. L. Xiao, C. Lei, J. Ren, T.-G. Liao, J.-X. Pu, C. U. Pittman, Y. Lu,Y.-T. Zheng, H.-J. Zhu*，H.-D. Sun* “Structure Elucidation and Theoretical Investigation of Key Steps in the Biogenetic Pathway of Schisanartane Nortriterpenoids Using DFT Methods”Chem.-A J. Eur.200814, 11584-11592.

28. L.-C. Li, J. Ren, J.-X. Jiang, H.-J. Zhu* “A Novel Direct Conversion of Primary Amides to the Corresponding Methyl Esters”Eur. J.Org. Chem. 2007, 1026-1030.

29. L. C. Li, J. X. Jiang, J. Ren, Y. Ren, C. U. Pittman, H. J. Zhu*, “Unexpected selectivity in sodium borohydride reductions of alpha-substituted esters: Experimental and theoretical studies”,Eur. J.Org. Chem.2006, 1981-1990.

30. J. Ren, L.-C. Li,J.-K. Liu, H. J. Zhu* C. U. Pittman, Jr., “Study of the Chemoselectivities of Primary, Secondary and Tertiary Amides in Sodium Borphydride Reactions”,Eur. J. Org. Chem.2006, 1991.

31. H. J. Zhu*, J. X. Jiang, S. Saobo, C. U. Pittman. “Chiral ligands Derived from Abrine 8. An Experimental and Theoretical Study of Free Ligand Conformational Preferences and the Addition of Diethylzinc to Benzaldehyde”J. Org. Chem.2005,70, 261-7.

32. H. J. Zhu, J. Ren, C. U. Pittman, Jr. “Matrix Model to Predict Specific Optical Rotations of Acyclic Chiral Molecules” Tetrahedron 2007, 63，2292-2314.

1. Hua-Jie Zhu, <Organic Stereochemistry---Experimental and computational methods>, Wiley-VCH，2015

2.朱華結(jié) 《現(xiàn)代有機(jī)立體化學(xué)》，科學(xué)出版社，2009.3。

1.朱華結(jié);李良春，神經(jīng)生長因子類似物（2S,4S）-2-（2u2019-取代基）-4-（吲哚-3-次甲基）-5,5-二取代基-1,3-噁唑烷化合物，其制備方法及應(yīng)用。專利號(hào)：ZL 2003 1 35767.9。

2.朱華結(jié);李良春;蔣舉興;任潔，一種伯酰胺轉(zhuǎn)化為相應(yīng)甲酯的方法。專利號(hào)：ZL 2004 1 004018.7。

3.朱華結(jié);呂曉,N-OR酰胺類化合物,其制備方法和其應(yīng)用。專利號(hào): 200710065964.4。

4.劉吉開;劉東澤;朱華結(jié);王 飛;湯建國，韌革菌素及其制備方法和在藥物上的應(yīng)用，200610048625.0

5.朱華結(jié);蔣舉興;任 潔，咔啉化合物,其應(yīng)用和制備方法。專利號(hào): ZL 200710066368.8。

6. 朱華結(jié)，李良波，任潔，二聯(lián)噻吩類化合物，其藥物組合物及應(yīng)用。專利號(hào)：2009 1 0218293.X

7.朱華結(jié);金 毅;徐樹光;楊兆祥;普俊學(xué)，一種新的燈盞花乙素衍生物、其制備方法及其藥物組合，200810097677.6

8.朱華結(jié);金 毅;徐樹光;楊兆祥;普俊學(xué)，4u2019,5,6-三甲氧基燈盞花乙素、其制備方法及其藥物組合物，200810097680.8。

9. 美國專利，Oxazolidine derivatives as NMDA antagonists,申請(qǐng)?zhí)?. 61/021,608 (文件號(hào): 026884-000200US（2008）)。PCT Int. Appl. 2009, 127pp. CODEN: PIXXD2 WO2009092324 A1 20090730.

10. 朱華結(jié)，白冰，1,1u2019-雙咔啉N,Nu2019-二氧軸手性催化劑的合成及應(yīng)用，ZL201110075166

11. 朱華結(jié)，白冰，李艷，β-咔啉衍生物或可藥用鹽，其制備方法及其抗腫瘤的應(yīng)用，201310139090.8

12. 朱華結(jié)等，五味子素結(jié)構(gòu)及其應(yīng)用，201310492922.4

13. 有關(guān)立體化學(xué)數(shù)據(jù)處理軟件著作權(quán)已獲得登記，2015，第1073141號(hào)。