1987年，武漢大學化學系，獲理學學士學位；

1990年，武漢大學化學系，獲理學碩士學位。之后在云南省化工研究院工作，從事天然香料等半合成研究；

1993年，中國科學院昆明植物研究所，獲理學博士學位。師承周俊院士，并拜師香港科技大學戴偉民教授及昆明植物所郝小江教授學習手性催化劑的設計與合成；

1998年，前往美國密西西比州立大學學習工作，并獲得Assistant Research Professor；

2003年，獲得中科院“國外杰出人才”；

2005年，到美國Virginia Tech （美國弗吉尼亞理工大學）做高級訪問學者；

2011年至今，作為高層人才到河北大學工作。

圍繞有機小分子的立體化學，尤其是天然產(chǎn)物的立體化學開展實驗與理論相結合的多學科交叉創(chuàng)新研究。

《有機立體化學》、《天然產(chǎn)物化學》、《藥物化學》。

1.主持：手性催化劑的構象對對映加成反應選擇性的影響，國家基金委“主任專項”。

2.主持：八種藏藥材資源調(diào)查與評價、化學成分分析，中國科學院重點項目

3.主持：天然產(chǎn)物化學中的應用計算化學研究，國家基金委基金

4.主持：手性噁唑烷的設計、合成及其在中樞神經(jīng)細胞保護中的活性研究，國家基金委基金

5.主持：中科院“國外杰出人才”基金。

6.主持：河北大學“高層引進人才”基金。

7.主要參與人：中國特有植物和微生物藥用活性物質(zhì)的基礎研究，973項目中的子課題項目

8.主要參與人：教育部創(chuàng)新團隊以及河北省“巨人計劃”。

1. Li Liu, Qing Yang, He Yu, Jing-Liang Li, Yu-Ning Pei, Hua-Jie Zhu,*Zhen-Qiu Li, Xiao-Ke Wang, “Fitness of Driving Force and Catalytic Space in Chiral Catalyst Design. Application of Axial Biscarboline N-O Chiral Catalysts for Enantioselective Allylation of Allyltrichlorosilane to Bulky Substituted Aldehydes”Tetrahedron. 2015,71, 3296-3302.

2. H. Yu, W-X Li,J.-C. Wang,Q. Yang, H.-J. Wang,C.-C. Zhang, S.-S. Ding, Y. Li,H.-J Zhu,* “Pestalotiopsin C, Stereochemistry of A New Caryophyllene from a Fungus ofTrichodermasp. and Its Tautomerization Characteristics in Solution”,Tetrahedron. 2015,71, 3491-3494.

3. D.-B. Hu, W.-X. Li, Z.-Z. Zhao, T. Feng, R.H. Yin, Z.-H. Li, J.-K. Liu, H. J. Zhu*. “Highly unsaturated pyranone derivatives from the basidiomycete Junghuhnianitida”Tetrahedron Lett.2014,55, 6530-6533.

4. Jin-Liang Li, Li Liu, Yu-Ning Pei, Hua-Jie Zhu*, “Copper(II)-containing C2-symmetric bistetracarboline amides in enantioselective Henry reactions”.Tetrahedron, 2014,70, 9077-9083.

5. Yu-NingPei, Yu Deng, Jing-Liang Li, Hua-Jie Zhu“Chiral BiscarbolineN,N’-Dioxide Derivatives Catalyzed Asymmetric Reduction of Ketoimines with Trichlorosilane”Tetrahedron Lett,2014.55, 2948-2952.

6. Bing Bai,Xing-Yao Li, Li Liu,Yan Li,Hua-Jie Zhu*, “Syntheses of Novelβ-Carboline Derivatives and the Activities against Five Tumor-Cell Lines” .Bioorg. Med. Chem. Lett.2014,24, 96u201398.

7. Ping He, Xiangfen Wang, Xiujie Guo, Chuanqi Zhou, Shigang Shen, Dongbao Hu, Xiaolong Yang, Duqiang Luo, Rina Dukor, Huajie Zhu* “Vibrational Circular Dichroism Study for Natural Schizandrin fromPyrola rotundifoliaL. and Reassignment of Its Absolute Configuration”,Tetrahedron Lett.2014, 55, 2965u20132968.

8. Hua-Jie Zhu,* Wen-Xin Li, Dong-Bao Hu, Meng-Liang Wen, “Discussion of Absolute Configuration for Bioactive Griseusins by Comparing Computed Optical Rotations and Electronic Circular Dichroism with the Experimental Results”Tetrahedron, 2014,70, 8236-8243.

9. Wei Pan, Dongbao Hu, He Yu, Huajie Zhu*, “Mechanism Investigation of Hydrosilylation of Ketimines with Trichlorosilane Using Asymmetric-Axle-Supported ChiralN-OAmides and Absolute Configuration Discussion forN-Substituted Aniline” ,Tetrahedron2014,69, 7253-7257

10.S. Zhang, D.-B. Hu, J.-B. He, K.-Y. Guan, H.-J. Zhu,* “A NovelTetrahydroquinoline Acid and Two NewBenzofuranones fromCapparis spinosaL., A Case Study of Absolute Configuration Determination Using Quantum Methods” ,Tetrahedron2014,70, 869-873

11. Jiang-Bo He, Yan-Nan Ji, Dong-Bao Hu, Shen Zhang, Hui Yan, Xin-Chun Liu, Huai-Rong Luo, Hua-Jie Zhu* “Structure and AbsoluteConfigurationofPenicilliumine, a New Alkaloid fromPenicillium commune366606”,TetrahedronLett.2014.55, 2684-2686.

12. W. Pan, Y. Deng, J.-B. He, B. Bai, H.-J. Zhu*, “Highly Efficient Asymmetric-Axle-Supported N-O Amides in EnantioselectiveHydrosilylation of Ketimines with Trichlorosilane”,Tetrahedron, 2013,69, 7253-.

13. B.-X. Zhao, Y. Wang, C. Li, G.-C. Wang, X.-J. Huang, C.-L. Fan, Q.-M. Li, H.-J. Zhu*, W.-M. Chen*, W.-C. Ye*, “Flueggedine, a novel axisymmetric indolizidine alkaloid dimer from Flueggea virosa”,Tetrahedron Lett. 2013,54, 4708-4711.

14.Y. Deng,W. Pan,Y.-N.Pei, J.-L. Li, X.-C. Liu H.-J. Zhu*, “Asymmetric Addition of Aldehydes with Allytrichlorosianes Catalyzed by AxialN-O Secondary Amides”Tetrahedron2013.69.10431-10437.

15. Q.-M. Li, J. Ren, L. Shen, B. Bai Q.-M. Li, X.-C. Liu and M.-L. Wen, H.-J. Zhu*, “Determining the Absolute Configuration of Benzopyrenomycin from Optical Rotation, Electronic Circular Dichroism and Population Analysis of Different Conformations via DFT Methods”.Tetrahedron2013,69,3067-3074.

16. J. Ren, G-L Li, L Shen, G-L Zhang, Larance Nafie, H-J Zhu,* “Challenges in the Assignment of Relative and Absolute Configurations of Complex Molecules”Tetrahedron.2013,69,10351-10356.

17. B-D. Zhou, J. Ren, X.-C. Liuand H.-J. Zhu* “Theoretical and Experimental Study of the Absolute Configuration of Helical Structure of (2R,3S)-Rubiginone A2 Analog”Tetrahedron.2013,69, 1189-1194.

18. B. Bai, H.-J. Zhu,*W. Pan,“Structure Influence of Chiral 1,1u2032-Biscarboline-N,Nu2032-Dioxide on the Enantioselective Allylation of Aldehydes with Allyltrichlorosilanes”Tetrahedron.2012.68, 6829-6836.

19. B. Bai, L. Shen, J. Ren, H. J. Zhu* “Chiral BiscarbolineN,N’-Dioxide Derivatives. Highly Enantioselective Addition of Allyltrichlorosilane to Aldehydes”Advanced Synthesis and Catalysts,2012,354, 354-358.

20. Z.-G. Ding, J.-Y. Zhao, M.-G. Li, R. Huang, Q.-M. Li, X.-L. Cui, H.-J. Zhu,* and M.-L. Wen* “Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species”J. Nat. Prod.2012,75, 1994?1998.

21. S.-D. Zhao, L. Shen, D.-Q. Luo, H.-J. Zhu* “Progresses in Computational Methods Used in Natural Product Chemistry”Cur. Org. Chem.2011,15, 1843.

22. X.-N. Li,Y. Zhang,X.-H. Cai, T. Feng, Y.-P. Liu, Y. Li,J. Ren,H.-J. Zhuand X.-D. Luo“Psychotripine: a Novel Trimeric Pyrroloindoline Derivative from Psychotria pilifera”O(jiān)rg. Lett. 2011,13, 5896-5899.

23. B. Bai,X.-Y. Li, Y. Li,H.-J. Zhu* “Design, Synthesis andCytotoxic Activities ofNovelβ- Amino Alcohol DerivativesBioorg. Med. Chem. Lett.2011,21, 2302-2304.

24. Z.-G. Ding,M.-G. Li,J. Ren,J.-Y. Zhao,R. Huang,Q.-Z. Wang,X.-L. Cui,H.-J. Zhu*and M.-L. Wen* “Phenazinolins Au2013E: novel diphenazines from a tin mine tailings-derivedStreptomycesspecie”O(jiān)rg. & Biomol. Chem.2011,9, 2771.

25. F. Wang, Y.Gao, L. Zhang, B. Bai, Y. N. Hu, Z. J. Dong, Q. W. Zhai, H.- J. Zhu,* J. K Liu,.* “A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity.”O(jiān)rg. Lett.2010,12, 3196-3199.

26. H-G. Ding, M.-G. Li, J.-Y. Zhao, J. Ren, R. Huang, M.-J. Xie, X.-L. Cui, H.-J. Zhu*, and M.-L. Wen* “Naphthospironone A, an Unprecedented Polycyclic Metabolite from an Alkaline Mine Waste Extremophile”.Chem.-A J. Eur. 2010,16, 3902 u2013 3905.

27. J. Ren,J.-X. Jiang, L.-B. Li,T.-G. Liao, R.-R. Tian, X.-L. Chen, S.-P. Jiang, C. U. Pittman, Jr. and H.-J. Zhu* “Assignment of Absolute Configuration ofConcentricolideand Absolute Configuration Determination of Its Bioactive Analogues Using DFT Methods.”Eur. J. Org. Chem. 2009. 3987-3991.

27. W. L. Xiao, C. Lei, J. Ren, T.-G. Liao, J.-X. Pu, C. U. Pittman, Y. Lu,Y.-T. Zheng, H.-J. Zhu*，H.-D. Sun* “Structure Elucidation and Theoretical Investigation of Key Steps in the Biogenetic Pathway of Schisanartane Nortriterpenoids Using DFT Methods”Chem.-A J. Eur.200814, 11584-11592.

28. L.-C. Li, J. Ren, J.-X. Jiang, H.-J. Zhu* “A Novel Direct Conversion of Primary Amides to the Corresponding Methyl Esters”Eur. J.Org. Chem. 2007, 1026-1030.

29. L. C. Li, J. X. Jiang, J. Ren, Y. Ren, C. U. Pittman, H. J. Zhu*, “Unexpected selectivity in sodium borohydride reductions of alpha-substituted esters: Experimental and theoretical studies”,Eur. J.Org. Chem.2006, 1981-1990.

30. J. Ren, L.-C. Li,J.-K. Liu, H. J. Zhu* C. U. Pittman, Jr., “Study of the Chemoselectivities of Primary, Secondary and Tertiary Amides in Sodium Borphydride Reactions”,Eur. J. Org. Chem.2006, 1991.

31. H. J. Zhu*, J. X. Jiang, S. Saobo, C. U. Pittman. “Chiral ligands Derived from Abrine 8. An Experimental and Theoretical Study of Free Ligand Conformational Preferences and the Addition of Diethylzinc to Benzaldehyde”J. Org. Chem.2005,70, 261-7.

32. H. J. Zhu, J. Ren, C. U. Pittman, Jr. “Matrix Model to Predict Specific Optical Rotations of Acyclic Chiral Molecules” Tetrahedron 2007, 63，2292-2314.

1. Hua-Jie Zhu, <Organic Stereochemistry---Experimental and computational methods>, Wiley-VCH，2015

2.朱華結 《現(xiàn)代有機立體化學》，科學出版社，2009.3。

1.朱華結;李良春，神經(jīng)生長因子類似物（2S,4S）-2-（2u2019-取代基）-4-（吲哚-3-次甲基）-5,5-二取代基-1,3-噁唑烷化合物，其制備方法及應用。專利號：ZL 2003 1 35767.9。

2.朱華結;李良春;蔣舉興;任潔，一種伯酰胺轉(zhuǎn)化為相應甲酯的方法。專利號：ZL 2004 1 004018.7。

3.朱華結;呂曉,N-OR酰胺類化合物,其制備方法和其應用。專利號: 200710065964.4。

4.劉吉開;劉東澤;朱華結;王 飛;湯建國，韌革菌素及其制備方法和在藥物上的應用，200610048625.0

5.朱華結;蔣舉興;任 潔，咔啉化合物,其應用和制備方法。專利號: ZL 200710066368.8。

6. 朱華結，李良波，任潔，二聯(lián)噻吩類化合物，其藥物組合物及應用。專利號：2009 1 0218293.X

7.朱華結;金 毅;徐樹光;楊兆祥;普俊學，一種新的燈盞花乙素衍生物、其制備方法及其藥物組合，200810097677.6

8.朱華結;金 毅;徐樹光;楊兆祥;普俊學，4u2019,5,6-三甲氧基燈盞花乙素、其制備方法及其藥物組合物，200810097680.8。

9. 美國專利，Oxazolidine derivatives as NMDA antagonists,申請?zhí)?. 61/021,608 (文件號: 026884-000200US（2008）)。PCT Int. Appl. 2009, 127pp. CODEN: PIXXD2 WO2009092324 A1 20090730.

10. 朱華結，白冰，1,1u2019-雙咔啉N,Nu2019-二氧軸手性催化劑的合成及應用，ZL201110075166

11. 朱華結，白冰，李艷，β-咔啉衍生物或可藥用鹽，其制備方法及其抗腫瘤的應用，201310139090.8

12. 朱華結等，五味子素結構及其應用，201310492922.4

13. 有關立體化學數(shù)據(jù)處理軟件著作權已獲得登記，2015，第1073141號。