研究方向
神經(jīng)遞質(zhì)和生物活性肽受體激活后對細胞膜離子通道的調(diào)控及其有關(guān)的跨膜信號轉(zhuǎn)導機制；細胞膜離子通道在神經(jīng)元和心血管等細胞的發(fā)育、增殖、遷移和凋亡中的變化規(guī)律及其作用；中樞神經(jīng)元突觸傳遞機制研究.
主要作品
1. Lin-Yun Liu, Xiao-Wei Fei, Zhao-Min Li,Yan-Ai Mei. The nonsteroidal anti-inflammatory drug, diclofenac, activates the transient outward K+ current in rat cereballer granule cells. Neuropharmacology 2005 (in press)
2. Bo-Xun Lu, Lin-Yun Liu, Zhao-Ming Li, Zhi-Hong Zhang,Yan-Ai Mei. Inhibition of Na+ channel currents in rat myoblasts by 4-aminopyridine. Toxicology and Applied Pharmacology. 2005 (in press)
3. Hu Chang-Long, Gao Zhen-Yu, Liu Zheng, Zhang Zhi-Hong,[[Mei YAn-ai]] 2-iodomelatonin prevents apoptosis of cerebellar granule neurons via inhibition of A-type transient outward K+ currents. J. Pineal Res. 2005, 38:53-61
4.Yan-Ai Mei, D. Vaudry et al, PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway. Evidence for the involvement of Ik in the anti-apoptosis action of PACAP. Eur. J. Neuronsci. 2004 14:225-230.
5．MiOu Zhou, Zheng Liu, ChangLong Hu, ZhiHong Zhang andYan-Ai MeiDevelopmental Regulation of a Na+-activated Fast Outward K+ Current in Rat Myoblasts. Cell Physiol Biochem 2004;14 ：225-230.
6．Lin-Yun Liu , Chang-Long Hu, Lai-ji Ma, Zhi-hong Zhang, andYan-Ai Mei. ET-1 inhibits B-16 murine melanoma cell migration by decreasing K+ currents. Cell Motility Cytoskel . 2004: 58:127-136.
7．Song Jiao, Ming-Ming Wu, Chang-Long Hu, Zhi-Hong Zhang andYan-Ai Mei. Melatonin receptor agonist 2-iodomelatonin prevents apoptosis of cerebellar granule neurons via K+ currents inhibition. J. Pineal Res. 2004; 36:109-116
. 8. Lai-Ji Ma , Lin-Yun Liu, Song Jiao, Shao-Ming Wei,Yan-Ai MeiCa2+- inactivated K+ current modulated by endothelin-I in B-16 murine melanoma cells. Pigment Cell Res. 2003,16:463-469
9．ZHOU Mi-ou, JIAO Song, LIU Zheng, ZHANG Zhi-hong,[[Mei YAn-ai]]. Luzindole, a melatonin receptor antagonist, inhibits the transient outward K+ current in rat cerebellar granule cells. Brain Res.2003,970: 169-177
10．Hua Wei, Yan Ai Mei, Jia Ting Sun, Han Ging Zhou, Zhi Fong Zhang. Regulation of sewlling-activated chloride channels in embryonic chick heart cells. Cell Res. 2003, 1: 21-28.
11. Wei DS,Mei YA, Bagal A, Kao JP, Thompson SM, Tang CM. Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons. Science. 2001 Sep 21;293(5538):2272-5.
12.Mei YA, Lee PP, Wei H, Zhang ZH, Pang SF. Melatonin and its analogs potentiate the nifedipine-sensitive high-voltage-activated calcium current in the chick embryonic heart cells. J Pineal Res. 2001 Jan;30(1):13-21.
13. Huan CL, Zhou MO, Wu MM, Zhang ZH,Mei YA. Melatonin receptor Activate the rectify inward K+ current by a MT2 melatonin receptor in cerebellar granule cells. Brain Res, 2001,917:182-190.
14. Wei H,Mei YA, Wu MM, Sun JT, Zhou HQ, Zhang ZH. Swelling-activated chloride currents in embryonic chick heart cells. Acta Pharmacol Sinica. 2000 Nov;21(11):986-90.
15.Mei YA, Wu MM, Huan CL, Sun JT, Zhou HQ, Zhang ZH. 4-aminopyridine, a specific blocker of K(+) channels, inhibited inward Na(+) current in rat cerebellar granule cells. Brain Res. 2000 Aug 4;873(1):46-53.
16.Mei YA, Huang LX, Wei H, Sun JT, Zhou HQ, Zhang ZH. Characterization of outward potassium current in embryonic chick heart cells. Acta Pharmacol Sinica. 1999 Apr;20(4):303-7.
17.Mei YA. High-voltage-activated calcium current and its modulation by dopamine D4 and pituitary adenylate cyclase activating polypeptide receptors in cerebellar granule cells. Acta Pharmacol Sinica. 1999 Jan;20(1):3-9.
18.Mei YA, Vaudry H, Cazin L. Patch clamp study on mechanism of adenosine-induced inhibitory effects in frog pituitary melanotrophs. Acta Pharmacol Sinica. 1996 Sep;17(5):385-9.
19. Soriani O, Vaudry H,Mei YA, Roman F, Cazin L. Sigma ligands stimulate the electrical activity of frog pituitary melanotrope cells through a G-protein-dependent inhibition of potassium conductances. J Pharmacol Exp Ther. 1998 286(1):163-71.
20.Mei YA, Soriani O, Castel H, Vaudry H, Cazin L. Adenosine potentiates the delayed-rectifier potassium conductance but has no effect on the hyperpolarization-activated Ih current in frog melanotrophs. Brain Res. 1998 793(1-2):271-8.
21.Mei YA, Vaudry H, Cazin L. Patch clamp study on mechanism of adenosine-induced inhibitory effects in frog pituitary melanotrophs. Acta Pharmacol Sinica. 1996 Sep;17(5):385-9.
22. Gonzalez BJ, Basille M,Mei YA, Vaudry D, Fournier A, Cazin L, Vaudry H. Ontogeny of PACAP and PACAP receptors in the rat brain: role of PACAP in the cerebellum during development. Ann N Y Acad Sci. 1996 26;805:302-13;
23.Mei YA, Le Foll F, Vaudry H, Cazin L. Adenosine inhibits L- and N-type calcium channels in pituitary melanotrophs. Evidence for the involvement of a G protein in calcium channel gating. J Neuroendocrinol. 1996 Feb;8(2):85-91.
24.Mei YA, Louiset E, Vaudry H, Cazin L. A-type potassium current modulated by A1 adenosine receptor in frog melanotrophs.J Physiol. 1995 Dec 1;489 ( Pt 2):431-42.
25.Mei YA, Griffon N, Buquet C, Martres MP, Vaudry H, Schwartz JC, Sokoloff P,Cazin L. Activation of dopamine D4 receptor inhibits an L-type calcium current in cerebellar granule cells. Neuroscience. 1995 Sep;68(1):107-16.
26.Mei YA, Vaudry H, Cazin L. Inhibitory effect of adenosine on electrical activity of frog melanotrophs mediated through A1 purinergic receptors. J Physiol. 1994 481 ( Pt 2):349-55.
27. Louiset E,Mei YA, Valentijn JA, Vaudry H, Cazin L. Characterization of the GABA-induced current in frog pituitary melanotrophs. J Neuroendocrinol. 1994 Feb;6(1):39-46.
獲獎情況
2009年度教育部自然科學獎二等獎（第一獲獎人）；2008年度上海市高校教學名師、2007年度上海市育才獎、2005年度寶鋼教育基金優(yōu)秀教師獎。