個人簡歷
1990～1994 天津南開大學化學系有機化學專業(yè) 本科
1994～1997 華西醫(yī)科大學藥學院藥物化學專業(yè) 碩士研究生
1998～2001 中科院成都有機化學研究所有機化學專業(yè) 博士研究生
2001～2002 中科院成都有機化學研究所 博士后研究
2002～2003 香港大學化學系 博士后研究
2003～ 四川大學華西藥學院 教授、博士生導師
現(xiàn)為第三軍醫(yī)大學藥學院藥物化學專業(yè) 教授
研究方向
1. 手性有機小分子催化的不對稱合成研究及手性藥物合成
2. （手性）卡賓催化的新反應研究
3. 新型可回收（手性）催化劑的設(shè)計、合成及催化反應研究
4. 新型藥物設(shè)計與合成
主要研究課題及成果
1. 基于硫脲活化的雙功能有機催化劑的合成及不對稱催化反應研究。（國家自然科學基金，2006-2008）
2. 新型水溶性紫杉醇前藥的研究。（教育部霍英東青年教師基金，2006-2008）
3. 新世紀優(yōu)秀人才支持計劃。（教育部，2006-2008）
4. 四川省青年科技基金。（四川省，2007－2009）
5. 手性伯胺有機催化劑的設(shè)計、合成及不對稱催化反應研究。（國家自然科學基金，2008-2010）
獲獎情況 2007年 四川省第九屆青年科技獎
代表性論著
1. Wei Chen,Wei Du,Yong-Zheng Duan,Yong Wu,Sheng-Yong Yang,Ying-Chun Chen,* “Enantioselective 1,3-dipolar cycloaddition of cyclic enones catalyzed by multifunctional primary amine: beneficial effects of hydrogen bonding”，Angew. Chem.,Int. Ed. 2007,46,7667.
2. Tian-Yu Liu,Hai-Lei Cui,Yan Zhang,Kun Jiang,Zhao-Quan He,Bang-Jing Li,Li-Sheng Ding,Ying-Chun Chen,* “Organocatalytic and highly enantioselective direct-amination of aromatic ketones”，Org. Lett. 2007,9,3671.
3. Tian-Yu Liu,Hai-Lei Cui,Qian Chai,Jun Long,Bang-Jing Li,Yong Wu,Li-Sheng Ding,Ying-Chun Chen,* “Organocatalytic asymmetric Friedel-Crafts alkylation/cascade reactions of naphthols and nitroolefins”，Chem. Commun. 2007,2228.
4. Lin Jiang,Hong-Ting Zheng,Tian-Yu Liu,Lei Yue,Ying-Chun Chen,* “Asymmetric direct vinylogous carbon-carbon bond formation catalyzed by bifunctional organocatalysts”，Tetrahedron 2007,63,5123.
5. Tian-Yu Liu,Hai-Lei Cui,Jun Long,Bang-Jing Li,Yong Wu,Li-Sheng Ding,Ying-Chun Chen,* “Organocatalytic and highly stereoselective direct vinylogous Mannich reaction”，J. Am. Chem. Soc. 2007,129,1878.
6. Wei Chen,Wei Du,Lei Yue,Rui Li,Yong Wu,Li-Sheng Ding and Ying-Chun Chen,* “Organocatalytic enantioselective indole alkylations of,?-unsaturated ketones”，Org. Biomol. Chem. 2007,5,816.
7. Jian-Wu Xie,Lei Yue,Wei Chen,Wei Du,Jin Zhu,Jin-Gen Deng and Ying-Chun Chen,* “Highly enantioselective Michael addition of cyclic 1,3-dicarbonyl compounds to,?-unsaturated ketones”，Org. Lett. 2007,9,413.
8. Jian-Wu Xie,Wei Chen,Rui Li,Mi Zeng,Wei Du,Lei Yue,Ying-Chun Chen,* Yong Wu,Jin Zhu,and Jin-Gen Deng,* “Highly asymmetric Michael addition of,?-unsaturated ketones catalyzed by 9-amino-9-deoxyepiquinine”，Angew. Chem.,Int. Ed. 2007,46,389.
9. Tian-Yu Liu,Rui Li,Qian Chai,Jun Long,Bang-Jing Li,Yong Wu,Li-Sheng Ding,Ying-Chun Chen,* “Enantioselective Michael addition of-substituted cyanoacetates to vinyl ketones catalyzed by bifunctional organocatalysts”，Chem.?Eur. J. 2007,13,319.
10. Wei Chen,Xiang-Hong Yuan,Rui Li,Wei Du,Yong Wu,Li-Sheng Ding,Ying-Chun Chen,* “Organocatalytic and stereoselective [3 + 2] cycloadditions of azomethine imines with,?-unsaturated aldehydes”，Adv. Synth. Catal. 2006,348,1818.
11. Wei Chen,Rui Li,Yong Wu,Li-Sheng Ding,Ying-Chun Chen,* “Self-supported thiourea-palladium complexes: highly air-stable and recyclable catalysts for the Suzuki reaction in neat water”，Synthesis 2006,3058.
12. Lin Jiang,Tong-Fei Wu,Ying-Chun Chen,* Jin Zhu,Jin-Gen Deng,* “Asymmetric transfer hydrogenation catalysed by hydrophobic dendritic DACH-rhodium complex in water”，Org. Biomol. Chem. 2006,4,3319.
13. Tian-Yu Liu,Jun Long,Bang-Jing Li,Lin Jiang,Rui Li,Yong Wu,Li-Sheng Ding,Ying-Chun Chen,* “Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst”，Org. Biomol. Chem. 2006,4,2097.
14. Qing-Ping Liu,Ying-Chun Chen,* Yong-Wu,Jin Zhu,Jin-Gen Deng,* “Self-supported heterogeneous star-shaped oxime-palladacycle catalysts for the Suzuki coupling reaction”，Synlett 2006,1503.
15. Yan-Kai Liu,Rui Li,Lei Yue,Ying-Chun Chen,* Yong Wu,Li-Sheng Ding，“Unexpected ring-opening reactions of aziridines with aldehydes catalyzed by nucleophilic carbenes under aerobic conditions”，Org. Lett. 2006,8,1521.
16. Jian-Wu Xie,Lei Yue,Dong Xue,Xiao-Li Ma,Ying-Chun Chen,* Yong Wu,Jin Zhu,Jin-Gen Deng,* “Organocatalytic and direct asymmetric vinylogous Michael addition of,?-dicyanoolefins to,?-unsaturated aldehydes”，Chem. Commun. 2006,1563.
17. Wei Chen,Rui Li,Bo Han,Bang-Jing Li,Ying-Chun Chen,* Yong Wu,Li-Sheng Ding,Dan Yang，“Design and synthesis of bis-thiourea ligands and their application in Pd-catalyzed Heck and Suzuki reactions under aerobic condition”，Eur. J. Org. Chem. 2006,1177.
18. Zhi-Quan Yong,Xiao-Ping Xu,Ying-Chun Chen,* Xu Bao,Ling-Ling Weng,* Hu Zheng，“Synthesis and cytotoxic activity of novel water-soluble prodrugs of combretastatin A-4”，Chin. Chem. Lett. 2006,17,23.
19. Dong Xue,Ying-Chun Chen,* Qi-Wei Wang,Ling-Feng Cun,Jin Zhu,Jin-Gen Deng,* “Asymmetric direct vinylogous Michael reaction of activated alkenes to nitroolefins catalyzed by modified cinchona alkaloids”，Org. Lett. 2005,7,5293.
20. Bang-Jing Li,Lin Jiang,Min Liu,Ying-Chun Chen,* Li-Sheng Ding,Yong Wu，“Asymmetric Michael addition of thiols to,?-unsaturated carbonyl compounds catalyzed by bifunctional organocatalyst”，Synlett 2005,603.
21. Dong Xue,Ying-Chun Chen,Qi-Wei Wang,Xin Cui,Jin Zhu,Jin-Gen Deng，“Transfer hydrogenation of activated C=C bonds catalyzed by ruthenium amido complexes: reaction scope,limitation,and enantioselectivity”，J. Org. Chem. 2005,70,3584.
22. Ying-Chun Chen,* Tong-Fei Wu,Lin Jiang,Xin Cui,Jin-Gen Deng,* Jin Zhu,Yao-Zhong Jiang，“Synthesis of dendritic ligands and application in asymmetric transfer hydrogenation”，J. Org. Chem. 2005,70,1006.
23. Chun-Yu Ho,Ying-Chun Chen,Man-King Wong,Dan Yang，“Fluorinated chiral secondary amines as catalysts for epoxidation of olefins with oxone”，J. Org. Chem. 2005,70,898.
24. Dan Yang,* Ying-Chun Chen,Nian-Yong Zhu，“Sterically bulky thioureas as air- and moisture-stable ligands for Pd-catalyzed Heck reactions of aryl halides”，Org. Lett. 2004,6,1577.
25. Ying-Chun Chen,Dong Xue,Jin-Gen Deng,Xin Cui,Jin Zhu,Yao-Zhong Jiang，“Efficient asymmetric transfer hydrogenation of activated olefins catalyzed by ruthenium amido complexes”，Tetrahedron Lett. 2004,45,1555.
26. Pei Nian Liu,Ying Chun Chen,Xue Qiang Li,Yong Qiang Tu,Jin Gen Deng，“Dendritic catalysts for asymmetric transfer hydrogenation based on （1S,2R)-norephedrine derived ligands”，Tetrahedron: Asymmetry 2003,14,2481.
27. Ying-Chun Chen,Tong-Fei Wu,Jin-Gen Deng,Hui Liu,Xin Cui,Jin Zhu,Yao-Zhong Jiang,Michael C. K. Choi and Albert S. C. Chan，“Multiple dendritic catalysts for asymmetric transfer hydrogenation”，J. Org. Chem. 2002,67,5301.
28. Ying-Chun Chen,Tong-Fei Wu,Jin-Gen Deng,Hui Liu,Yao-Zhong Jiang,Michael C. K. Choi and Albert S. C. Chan，“Dendritic catalysts for asymmetric transfer hydrogenation”，Chem. Commun. 2001,1488.
29. Peilian Liu,Yingchun Chen,Jingen Deng,Yongqiang Tu，“Efficient method for the preparation of benzylic bromides”，Synthesis 2001,2078.
