2006/09－2009/07，美國(guó)紐約州立布法羅大學(xué)生理與生物物理系，聯(lián)合培養(yǎng)博士生

2006/09－2009/07，華中科技大學(xué)生命科學(xué)與技術(shù)學(xué)院生物物理專業(yè)，博士

2002/09－2005/07，華中科技大學(xué)生命科學(xué)與技術(shù)學(xué)院生物物理專業(yè)，碩士

1996/09－2000/07，華中科技大學(xué)生命科學(xué)與技術(shù)學(xué)院生物技術(shù)專業(yè)，本科

2012/12-至今，武漢大學(xué)，生命科學(xué)學(xué)院，細(xì)胞與發(fā)育生物學(xué)系，教授

2011/02-2012/12，華中科技大學(xué)，生命科學(xué)與技術(shù)學(xué)院，分子生物物理教育部重點(diǎn)實(shí)驗(yàn)室，教授

2005/10-2011/01，美國(guó)紐約州立布法羅大學(xué)，生理與生物物理系，先后擔(dān)任研究助理與博士后

中國(guó)生物物理學(xué)會(huì)“膜與細(xì)胞生物物理專業(yè)委員會(huì)”委員中國(guó)生物物理學(xué)會(huì)“神經(jīng)生物物理與神經(jīng)信息專業(yè)委員會(huì)”委員中國(guó)神經(jīng)科學(xué)學(xué)會(huì)“離子通道與受體專業(yè)委員會(huì)”委員

離子通道的結(jié)構(gòu)和功能正常是維持生命過(guò)程的基礎(chǔ)，其結(jié)構(gòu)或功能的異常會(huì)導(dǎo)致許多先天性或后天獲得性疾病，稱為離子通道病。離子通道功能的減弱或增強(qiáng)均會(huì)導(dǎo)致機(jī)體生理功能的紊亂，主要累及神經(jīng)、肌肉、心臟、腎臟等系統(tǒng)或器官。瞬時(shí)受體勢(shì)(transient receptor potential, TRP)通道是人類感覺(jué)系統(tǒng)的先驅(qū)，由于可以響應(yīng)從細(xì)胞內(nèi)至細(xì)胞外的多種刺激而被稱為多覺(jué)感受器。其中的溫度敏感型TRP通道除了可被溫度激活外，還可被各種物理或化學(xué)因素激活，激活的溫敏型TRP通道不但介導(dǎo)溫度感知，而且還參與痛覺(jué)的形成和傳導(dǎo)、癢覺(jué)發(fā)生以及皮膚神經(jīng)源炎癥發(fā)生，因此，溫度敏感型TRP通道已成為治療疼痛、炎癥和瘙癢等疾病的重要新型分子靶標(biāo)。目前，我們研究小組主要聚焦于膜離子通道和神經(jīng)細(xì)胞信號(hào)傳導(dǎo)的研究，以闡述離子通道與神經(jīng)細(xì)胞信號(hào)調(diào)控的關(guān)系為主要研究目標(biāo)，重點(diǎn)關(guān)注與痛覺(jué)及傷害性傳導(dǎo)密切相關(guān)的離子通道的生物學(xué)功能和作用機(jī)制。主要從以下幾個(gè)方面開(kāi)展：
1) 溫度敏感型TRP通道的門(mén)控機(jī)制與功能結(jié)構(gòu)域鑒定；
2) 重要疾病中離子通道和神經(jīng)信號(hào)調(diào)控異常的分子機(jī)制，并同時(shí)探究離子通道在生理與病理中的作用；
3) 為相關(guān)離子通道類疾病的藥物篩選和治療提供潛在的作用靶標(biāo)，進(jìn)而指導(dǎo)新藥發(fā)現(xiàn)。

本科生課程：“神經(jīng)生物學(xué)”（2學(xué)分）和“專業(yè)文獻(xiàn)研讀”（2學(xué)分）
研究生課程：“細(xì)胞生物學(xué)研究方法”（2學(xué)分）

1) 國(guó)家自然科學(xué)基金面上項(xiàng)目（No. 31271209），2013-2016 （主持）

2) 教育部博士點(diǎn)基金（No. 20120142120062）2013-2015（主持）
3) 國(guó)家科技部973課題（No. 2014CB91300），2014-2018（學(xué)術(shù)骨干）
4)國(guó)家自然科學(xué)基金—海外及港澳學(xué)者合作研究基金（No. 31328007），2014-2015（主持）
5) 武漢大學(xué)拔尖創(chuàng)新人才資助項(xiàng)目（No. 2042014kf0230），2014-2015（主持）
6) 國(guó)家自然科學(xué)基金面上項(xiàng)目（No. 81372149），2014-2017，（作為項(xiàng)目研究的外協(xié)方參與）
7) 湖北省自然科學(xué)基金重點(diǎn)項(xiàng)目（No. 2015CFA095） 2015-2017（主持）
8)生命有機(jī)化學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室開(kāi)放基金，2015-2017（主持）
9) 國(guó)家自然科學(xué)基金—海外及港澳學(xué)者合作研究基金（No. 31628005），2017-2018（主持）
10) 國(guó)家自然科學(xué)基金面上項(xiàng)目（No. 31671209），2017-2020（主持）

(1) Yao Xiao, Maomao Gao, Luna Gao, Yu Zhao, Qiang Hong, Zhigang Li, Jing Yao, Hanhua Cheng , and Rongjia Zhou . Directed Differentiation of Zebrafish Pluripotent Embryonic Cells to Functional Cardiomyocytes. Stem Cell Reports. 2016 Aug 23. pii: S2213-6711(16)30144-8. doi: 10.1016/j.stemcr.2016.07.020.

(2) Yujie Ren, Yin Zhao, Dandan Lin, Ximing Xu, Qiyun Zhu, Jing Yao, Hong-Bing Shu and Bo Zhong . The type I interferon-IRF7 axis mediates transcriptional expression of Usp25. J. Biol. Chem. 2016 Jun 17;291(25):13206-15. doi: 10.1074/jbc.M116.718080.

(3) Chuangeng Zhang , Zili Xie , Xinxin Li, Jing Chen, Jing Feng, Yange Lang, Weishan Yang, Wenxin Li, Zongyun Chen, Jing Yao, Zhijian Cao and Yingliang Wu . Molecular basis for the toxin insensitivity of scorpion voltage-gated potassium channel MmKv1. Biochem. J., 2016 May 1;473(9):1257-66. doi: 10.1042/BCJ20160178. Epub 2016 Mar 7.

(4) Luna Gao, Pu Yang, Peizhong Qin, Yungang Lu, Xinxin Li, Quan Tian, Yang Li, Chang Xie, Jin-Bin Tian, Chengwei Zhang, Changlin Tian, Michael X. Zhu , Jing Yao. Selective potentiation of 2-APB-induced activation of TRPV1-3 channels by acid. Sci. Rep. 2016 Feb; 6, 20791; doi: 10.1038/srep20791. ( corresponding author)

(5) Chang Xie, Haowen Liu, Na Pan, Jiuping Ding and Jing Yao. The residue I257 at S4-S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols. Acta Pharmacol. Sin. 2016 Jan; 37(1):124-33. ( corresponding author)

(6) Xiang Yang Zhang , Jingmin Wen , Wei Yang , Cheng Wang, Luna Gao, Liang Hong Zheng, Tao Wang, Kaikai Ran, Yulei Li, Xiangyang Li, Ming Xu, Junyu Luo, Shenglei Feng, Xixiang Ma, Hongying Ma, Zuying Chai, Zhuan Zhou, Jing Yao, Xue Zhang, Jing Yu Liu . Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain. Am. J. Hum. Genet., 2013 Nov. 7; 93(5):957-66. Doi: 10.1016/ j.ajhg.2013.09.016 ( corresponding author)

(7) Lu Zeng, Wenqiang Liu, Wenguo Feng, Xing Wang, Hui Dang, Luna Gao, Jing Yao and Xianqin Zhang . A novel donor splice-site mutation of major intrinsic protein gene associated with congenital cataract in a Chinese family. Mol Vis. 2013 Nov 14;19:2244-9.

(8) Ying Wu , Yongfeng Liu , Panpan Hou , Zonghe Yan, Wenjuan Kong, Beiying Liu , Xia Li, Jing Yao, Yuexuan Zhang, Feng Qin , Jiuping Ding . TRPV1 Channels Are Functionally Coupled with BK(mSlo1) Channels in Rat Dorsal Root Ganglion (DRG) Neurons. PLoS One. 2013 Oct 16; 8(10):e78203. doi: 10.1371/journal.pone.0078203.

(9) Panpan Hou , Wenping Zeng , Geliang Gan , Caixia Lv , Xiying Guo, Zheng Zhang, Haowen Liu, Ying Wu, Jing Yao, Aguan D., Wei, Sheng Wang and Jiuping Ding. Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BKCa(β2). Sci Rep. 2013 Apr 16; 3:1666. P1-8. doi: 10.1038/srep01666.

(10) Lisi Wei , Su Chen , Xianju Huang, Jing Yao and Xiangming Liu. Material basis for inhibition of dragonu2019s blood on capsaicin-induced TRPV1 receptor currents in rat dorsal root ganglion neurons. Eur J Pharmacol. 2013 Feb 28; 702(1-3):275-84. doi: 10.1016/j.ejphar.2013.01.052. Epub 2013 Feb 8.

(11) Wei Wang , Feng Xiao , Xuhui Zeng, Jing Yao, Ming Yuchi and Jiuping Ding. Optimal Estimation of Ion-channel Kinetics from Macroscopic Currents. Plos One. 2012 Mar; 7(4):e35208. Epub 2012 Apr 20.

(12) Cheng Wang , Yulei Li , Lei Shi , Jie Ren, Monica Patti, Tao Wang, Jo?o R M de Oliveira, María-Jesús Sobrido, Beatriz Quintáns, Miguel Baquero, Xiaoniu Cui, Xiang-Yang Zhang, Lianqing Wang, Haibo Xu, Junhan Wang, Jing Yao, Xiaohua Dai, Juan Liu, Lu Zhang, Hongying Ma, Yong Gao, Xixiang Ma, Shenglei Feng, Mugen Liu, Qing K Wang, Ian C Forster, Xue Zhang & Jing-Yu Liu. Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nat Genet. 2012 Feb 12. 44(3):254-6. doi: 10.1038/ng.1077.

(13) Beiying Liu , Jing Yao and Feng Qin. Hysteresis of Gating Underlines Sensitization of TRPV3 Channels. J Gen Physiol. 2011 Nov; 138(5):509-20. (Co-first author, Recommended by Faculty of 1000)

(14) Jing Yao , Beiying Liu and Feng Qin. Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels. Proc. Natl. Aca. Sci. USA. 2011 Jul 5; 108(27):11109-14.

(15) Jing Yao , Beiying Liu and Feng Qin. Pore turret of thermal TRP channels is not essential for temperature sensing. Proc. Natl. Aca. Sci. USA. 2010, Aug 10; 107(32):E125.

(16) Jing Yao , Beiying Liu and Feng Qin. Kinetics and Energetic Analysis of Thermally Activated TRPV1 channels. Biophys. J. 2010 Sep 22; 99(6):1743-53.

(17) Beiying Liu , Jing Yao Yingwei Wang , Hui Li and Feng Qin. Proton inhibition of Unitary Currents of Vanilloid Receptors. J Gen Physiol.2009 Aug 31; 134(3):243-58. (Co-first author)

(18) Jing Yao , Beiying Liu and Feng Qin. Rapid temperature jump by infrared diode laser irradiation for patch-clamp studies. Biophys. J. 2009 May 6; 96(9): 3611-9.

(19) Jing Yao and Feng Qin. Interaction with phosphoinositides confers adaptation of pain receptors TRPV1. PLos. Biol. 2009 Feb.24, 7 (2): e46.

(20) Sujung Ryu , Beiying Liu , Jing Yao , Qiang Fu ang Feng Qin. Uncoupling proton activation of vanilloid receptor TRPV1. J Neurosci. 2007 Nov 21，27(47): 12797-807. (Co-first author)

(21) Xiaotian Tong , Jing Yao , Feng He, Xiang Chen, X. Zheng, Chang Xie, Gong Wu, Naixia Zhang, Jiuping Ding and Houming Wu. NMR solution structure of BmK-betaIT, an excitatory scorpion beta-toxin without a ’hot spot’ at the relevant position. Biochem Biophys Res Commun. 2006 Oct 27; 349(3): 890-9. (Co-first author)

(22) Hui Li , Jing Yao , Xiaotian Tong, Zhaohua Guo, Ying Wu, Liang Sun, Na Pan, Houming Wu, Tao Xu, and Jiuping Ding. Interaction sites between the Slo1 pore and the NH₂terminus of the β2 subunit, probed with a three-residue sensor. J Biol Chem, 2007, 282(24): 17720-8. (Co-first author)

(23) Jing Yao , Hui Li , Geliang Gan, Ying Wu, and Jiuping Ding. Residue Phe266 in S5-S6 loop is not critical for Charybdotoxin binding to Ca -activated K (mSlo1) channels. Acta Pharmacologica Sinica, 2006, 27: 945-9.

(24) Jing Yao , Xiang Chen , Hui Li, Yang Zhou, Lijun Yao, Gong Wu, Xiaoke Chen, Naixia Zhang, Zhuan Zhou, Tao Xu, Houming Wu, and Jiuping Ding. BmP09, a “Long Chain” scorpion peptide blocker of BK channels. J Biol Chem, 2005, 280: 14819-28.