簡(jiǎn)歷：
章海兵博士1997年畢業(yè)于山東大學(xué)獲學(xué)士學(xué)位；2005年畢業(yè)于中科院上海生科院健康科學(xué)研究所獲博士學(xué)位。2006-2013先后在美國(guó)托馬斯杰弗遜大學(xué)和費(fèi)城兒童醫(yī)院從事博士后研究。2013年初加入中國(guó)科學(xué)院上海生命科學(xué)研究院營(yíng)養(yǎng)科學(xué)研究所，擔(dān)任研究員、研究組長(zhǎng)。
研究方向：
本研究組主要研究細(xì)胞凋亡和細(xì)胞程序性壞死的分子機(jī)制，以及相關(guān)的免疫調(diào)節(jié)參與代謝疾病的分子機(jī)理。研究手段和技術(shù)主要包括蛋白質(zhì)組學(xué)的篩選、分子生物學(xué)、細(xì)胞生物學(xué)、基因敲除動(dòng)物模型以及動(dòng)物疾病模型等。通過(guò)探索細(xì)胞死亡、炎癥、代謝疾病之間的關(guān)系，為疾病的治療提供依據(jù)。
職稱：
研究員
職務(wù)：
細(xì)胞死亡與免疫代謝研究組組長(zhǎng)
代表論著：
- Zhang J,Zhang H, Li J, Rosenberg S, Zhang EC, Zhou X, Qin F, Farabaugh M. RIP1-mediated regulation of lymphocyte survival and death responses.Immunol Res. 2011 Dec; 51(2-3):227-36.Cho Y, McQuade T,Zhang H, Zhang J, Chan FK. RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation.PLoS One. 2011;6(8):e23209. Epub 2011 Aug 10.Zhang H, Zhou X, McQuade T, Li J, Chan FK, Zhang J. Functional complementation between FADD and RIP1 in embryos and lymphocytes.Nature. 2011 Mar 17; 471(7338):373-6.Rosenberg S,Zhang H, Zhang J. FADD deficiency impairs early hematopoiesis in the bone marrow.J Immunol. 2011 Jan 1; 186(1):203-13.Zhang H, Hou YJ, Han SY, Zhang EC, Huebner K, Zhang J. Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells.Int Immunol. 2009 Jun; 21(6):691-703.Zhang H, Rosenberg S, Coffey FJ, He YW, Manser T, Hardy RR, Zhang J.A role for cFLIP in B cell proliferation and stress MAPK regulation.J Immunol. 2009 Jan 1; 182(1):207-15.Imtiyaz HZ, Zhou X,Zhang H, Chen D, Hu T, Zhang J. The death domain of FADD is essential for embryogenesis, lymphocyte development, and proliferation.J Biol Chem. 2009 Apr 10; 284(15):9917-26.Zhang H, Zhang Q, Wang L, Chen H, Li Y, Cui T, Huang W, Zhang L, Yan F, Wang L, Xu Y, Hu L, Kong X.Association of IL4R gene polymorphisms with asthma in Chinese populations.Hum Mutat. 2007 Oct; 28(10):1046.Zhang H, Q Zhang, L Wang, F Yan, Y Lu, Z Wang, J Li, Y Yu, Z Zhu, X Kong, L Hu. Genetic analysis of the liver putative tumor suppressor (LPTS) gene in gastric cancer.Korean Journal of Genetics. 2005.December, 27(4):271-278.Cui B,Zhang H, Lu Y, Zhong W, Pei G, Kong X, Hu L.Refinement of the locus for non-syndromic sensorineural deafness (DFN2).J Genet. 2004 Apr; 83(1):35-8.Wang X, Liu J,Zhang H, Xiao M, Li J, Yang C, Lin X, Wu Z, Hu L, Kong X. Novel mutations in the IRF6 gene for Van der Woude syndrome.Hum Genet. 2003 Oct; 113(5):382-6.
