孫雪松： 女,黑龍江,民族：漢,黨派：共產(chǎn)黨,博士，暨南大學(xué)研究員，博士研究生導(dǎo)師。從攻讀博士開(kāi)始至今一直致力于生物無(wú)機(jī)化學(xué)及功能蛋白組學(xué)的研究，著眼于細(xì)菌的金屬離子代謝、毒力及耐藥機(jī)制的研究。在該領(lǐng)域的研究結(jié)果已經(jīng)在國(guó)際一流刊物上發(fā)表SCI論文30余篇，其中第一作者及通訊作者24篇，單篇最高引用率達(dá)150次，總引用率﹥600次，H因子：10。應(yīng)邀為Expert Rev. Proteomics, Metallomics，Curr. Drug. Metab. J Proteomics等期刊撰寫(xiě)本研究領(lǐng)域的綜述性文章。研究結(jié)果得到同行專家的高度評(píng)價(jià)。發(fā)表在Metallomics上的文章被作為封面刊登，并且被評(píng)為該雜志當(dāng)年最熱門(mén)的十篇文章之一。曾多次應(yīng)邀在全國(guó)蛋白組學(xué)、亞洲生物無(wú)機(jī)化學(xué)大會(huì)等做學(xué)術(shù)報(bào)告。主持國(guó)家科技部“973”項(xiàng)目子課題1項(xiàng)，國(guó)家自然科學(xué)基金1項(xiàng)，廣東省自然科學(xué)基金2項(xiàng)，廣州市科技計(jì)劃1項(xiàng)，暨南大學(xué)引進(jìn)人才啟動(dòng)經(jīng)費(fèi)1項(xiàng)。2011年年獲得廣州市首批珠江科技新星計(jì)劃資助。學(xué)習(xí)經(jīng)歷：

2003-2006: 博士學(xué)位 香港大學(xué)

1999-2002: 碩士學(xué)位 南開(kāi)大學(xué)/中科院微生物所

1995-1999: 學(xué)士學(xué)位 南開(kāi)大學(xué)

工作經(jīng)歷：

2011-現(xiàn)在：暨南大學(xué)生命與健康工程研究院，研究員

2008-2011：暨南大學(xué)生命與健康工程研究院，副研究員

2007-2008：香港大學(xué), 博士后

研究方向：

細(xì)菌感染及耐藥相關(guān)機(jī)制的研究

細(xì)菌中的金屬轉(zhuǎn)運(yùn)機(jī)制

主要著作：

1. Xuesong Sun, Jen-Fu Chiu, Qing-Yu He, “Fractionation of proteins by immobilized metal affinity chromatography”, Methods Mol. Biol. 2008, 424:205-12.(專著)

2. 《功能蛋白質(zhì)研究》第四、五章，科學(xué)出版社，2012

主要論文：

1. Guo, Z., Han, J., Yang, X. Y., Cao, K., He, K., Du, G., Zeng, G., Zhang, L., Yu, G., Sun, Z., He, Q. Y.*, and Sun, X.* (2015) Proteomic analysis of the copper resistance of Streptococcus pneumoniae. Metallomics : integrated biometal science, 7(3):448-54

2. Yang, X. Y., Zhang, L., Liu, J., Li, N., Yu, G., Cao, K., Han, J., Zeng, G., Pan, Y., Sun, X., and He, Q. Y.* (2014) Proteomic analysis on the antibacterial activity of a Ru(II) complex against Streptococcus pneumoniae. J Proteomics, 115C, 107-116

3. Yang, X. Y., Sun, B., Zhang, L., Li, N., Han, J., Zhang, J., Sun, X.*, and He, Q. Y. * (2014) Chemical interference with iron transport systems to suppress bacterial growth of Streptococcus pneumoniae. PLoS One, 9, e105953

4. Wu, X., Xu, L., Gu, W., Xu, Q., He, Q. Y.*, Sun, X.*, and Zhang, G*. (2014) Iterative genome correction largely improves proteomic analysis of nonmodel organisms. J Proteome Res, 13, 2724-2734

5. Wang, N., Zhang, J., Zhang, L., Yang, X. Y., Li, N., Yu, G., Han, J., Cao, K., Guo, Z., Sun, X.*, and He, Q. Y.* (2014) Proteomic analysis of putative heme-binding proteins in Streptococcus pyogenes. Metallomics : integrated biometal science, 6, 1451-1459

6. Li, N., Yang, X. Y., Guo, Z., Zhang, J., Cao, K., Han, J., Zhang, G., Liu, L., Sun, X.*, and He, Q. Y.* (2014) Varied metal-binding properties of lipoprotein PsaA in Streptococcus pneumoniae. J Biol Inorg Chem, 19, 829-838

7. Ge, R., and Sun, X.* (2014) Iron acquisition and regulation systems in Streptococcus species. Metallomics : integrated biometal science, 6, 996-1003

8. Sun, X.*, Yu, G., Xu, Q., Li, N., Xiao, C., Yin, X., Cao, K., Han, J., and He, Q. Y.* (2013) Putative cobalt- and nickel-binding proteins and motifs in Streptococcus pneumoniae. Metallomics : integrated biometal science, 5, 928-935

9. Li, H., Li, N., Xu, Q., Xiao, C., Wang, H., Guo, Z., Zhang, J., Sun, X.*, and He, Q. Y.* (2013) Lipoprotein FtsB in Streptococcus pyogenes binds ferrichrome in two steps with residues Tyr137 and Trp204 as critical ligands. PLoS One, 8, e65682

10. Yang, X. Y., Lu, J., Sun, X.*, and He, Q. Y.* (2012) Application of subproteomics in the characterization of Gram-positive bacteria. J Proteomics, 75, 2803-2810

11. Sun, X.*, Yang, X. Y., Yin, X. F., Yu, G., Xiao, C. L., He, X., and He, Q. Y.* (2011) Proteomic analysis of membrane proteins from Streptococcus pneumoniae with multiple separation methods plus high accuracy mass spectrometry. OMICS, 15, 683-694

12. Sun, X., Xiao, C. L., Ge, R., Yin, X., Li, H., Li, N., Yang, X., Zhu, Y., He, X., and He, Q. Y.* (2011) Putative copper- and zinc-binding motifs in Streptococcus pneumoniae identified by immobilized metal affinity chromatography and mass spectrometry. Proteomics, 11, 3288-3298

13. Sun, X.*, Jia, H. L., Xiao, C. L., Yin, X. F., Yang, X. Y., Lu, J., He, X., Li, N., Li, H., and He, Q. Y.* (2011) Bacterial proteome of streptococcus pneumoniae through multidimensional separations coupled with LC-MS/MS. OMICS, 15, 477-482

14. Ge, R., Sun, X.#（共同第一）, Xiao, C., Yin, X., Shan, W., Chen, Z., and He, Q. Y.* (2011) Phosphoproteome analysis of the pathogenic bacterium Helicobacter pylori reveals over-representation of tyrosine phosphorylation and multiply phosphorylated proteins. Proteomics, 11, 1449-1461

15. Ge, R., Sun, X.#, and He, Q. Y.* (2011) Overview of the Metallometabolomic Methodology for Metal-Based Drug Metabolism. Curr Drug Metab,

16. Sun, X., Ge, R., Zhang, D., Sun, H., and He, Q. Y.* (2010) Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter of Streptococcus pyogenes. J Biol Inorg Chem, 15, 1265-1273

17. Sun, X., Ge, F., Xiao, C. L., Yin, X. F., Ge, R., Zhang, L. H., and He, Q. Y.* (2010) Phosphoproteomic analysis reveals the multiple roles of phosphorylation in pathogenic bacterium Streptococcus pneumoniae. J Proteome Res, 9, 275-282

18. Sun, X., Ge, R., Cai, Z., Sun, H., and He, Q. Y.* (2009) Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2. J Inorg Biochem, 103, 1074-1081

19. Sun, X., Baker, H. M., Ge, R., Sun, H., He, Q. Y.*, and Baker, E. N. * (2009) Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes. Biochemistry, 48, 6184-6190

20. Sun, X., Ge, R., Chiu, J. F., Sun, H., and He, Q. Y.* (2008) Identification of Proteins Related to Nickel Homeostasis in Helicobater pylori by Immobilized Metal Affinity Chromatography and Two-Dimensional Gel Electrophoresis. Met Based Drugs, 2008, 289490

21. Sun, X., Ge, R., Chiu, J. F., Sun, H., and He, Q. Y.* (2008) Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion. FEBS Lett, 582, 1351-1354

22. Sun, X., Chiu, J. F., and He, Q. Y.* (2008) Fractionation of proteins by immobilized metal affinity chromatography. Methods Mol Biol, 424, 205-212

23. Sun, X., Chiu, J. F., and He, Q. Y.* (2005) Application of immobilized metal affinity chromatography in proteomics. Expert Rev Proteomics, 2, 649-657

24. Sun, X., Sun, H., Ge, R., Richter, M., Woodworth, R. C., Mason, A. B., and He, Q. Y.* (2004) The low pKa value of iron-binding ligand Tyr188 and its implication in iron release and anion binding of human transferrin. FEBS Lett, 573, 181-185

25. Zhou, Q., Qi, S., Sun, X., and Ge, R. (2014) The interaction of a histidine-rich protein hpn with the membrane mimics: implications for pathologic roles of Hpn in Helicobacter pylori. Helicobacter, 19, 129-135

26. Xiao, C. L., Chen, X. Z., Du, Y. L., Sun, X., Zhang, G., and He, Q. Y.* (2013) Binomial probability distribution model-based protein identification algorithm for tandem mass spectrometry utilizing peak intensity information. J Proteome Res, 12, 328-335

27. Ge, R., Sun, X., Wang, D., Zhou, Q., and Sun, H.* (2011) Histidine-rich protein Hpn from Helicobacter pylori forms amyloid-like fibrils in vitro and inhibits the proliferation of gastric epithelial AGS cells. Biochim Biophys Acta, 1813, 1422-1427

28. Ge, R., and Sun, X. (2011) The in vivo functions of a histidine-rich protein Hpn in Helicobacter pylori: linking gastric and Alzheimer’s diseases together? Med Hypotheses, 77, 788-790

29. Ge, R., and Sun, X. (2012) Iron trafficking system in Helicobacter pylori. Biometals, 25, 247-58.

30. Ge, R., Sun, X., Gu, Q., Watt, R. M., Tanner, J. A., Wong, B. C., Xia, H. H., Huang, J. D., He, Q. Y.*, and Sun, H. (2007) A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori. J Biol Inorg Chem, 12, 831-842

31. Ge, R., Zhang, Y., Sun, X., Watt, R. M., He, Q. Y., Huang, J. D., Wilcox, D. E., and Sun, H.* (2006) Thermodynamic and kinetic aspects of metal binding to the histidine-rich protein, Hpn. J Am Chem Soc, 128, 11330-11331

32. Ge, R., Watt, R. M., Sun, X., Tanner, J. A., He, Q. Y.*, Huang, J. D.*, and Sun, H.* (2006) Expression and characterization of a histidine-rich protein, Hpn: potential for Ni2+ storage in Helicobacter pylori. Biochem J, 393, 285-293

33. Yang, P. H., Sun, X., Chiu, J. F., Sun, H., and He, Q. Y.* (2005) Transferrin-mediated gold nanoparticle cellular uptake. Bioconjug Chem, 16, 494-496

34. Ge, R., Lin, H., Xu, X., Sun, X., Zhu, S., Ji, B., Li, F., and Wu, H. (2004) Catalysis of phosphoryl transfer from adenosine-5’-triphosphate (ATP) by trinuclear "chelate" complexes. J Inorg Biochem, 98, 917-924

35. Xue, Y., Sun, X., Zhou, P., Liu, R., Liang, F., and Ma, Y. * (2003) Gordonia paraffinivorans sp. nov., a hydrocarbon-degrading actinomycete isolated from an oil-producing well. Int J Syst Evol Microbiol, 53, 1643-1646

承擔(dān)課題：

1. 結(jié)腸癌及其相關(guān)巨噬細(xì)胞的分泌蛋白質(zhì)與腫瘤發(fā)展的相關(guān)研究（2011CB910701）。國(guó)家科技部“973” 子課題 ，36萬(wàn)，2011.1-2012-12。

2.肺炎鏈球菌中錳轉(zhuǎn)運(yùn)蛋白PsaA錳離子結(jié)合特性的研究（31000373）。國(guó)家自然基金-青年基金， 20萬(wàn)， 2011.1-2013.12。

3. 鋅蛋白介導(dǎo)的肺炎鏈球菌鋅離子攝取機(jī)制的研究（S2012010008685）。 廣東省自然基金，5萬(wàn)，2012-2014.9。

4. 基于脂蛋白PsaA的肺炎鏈球菌錳運(yùn)輸機(jī)制的研究（10451063201005247）。廣東省自然基金，3 萬(wàn)，2010.10-2012.9。

5. 肺炎鏈球菌錳攝取機(jī)制的研究（33111013）。廣州市珠江科技新星計(jì)劃，30萬(wàn)，2012.1-2013.12。

6. 肺炎鏈球菌錳轉(zhuǎn)運(yùn)機(jī)制的研究（21611201）。暨南大學(xué)創(chuàng)新與培育項(xiàng)目-杰出人才，60萬(wàn)，2011.1-2013.12。

7. 肺炎鏈球菌錳轉(zhuǎn)運(yùn)機(jī)制的研究（21609301）。暨南大學(xué)創(chuàng)新與培育項(xiàng)目-青年項(xiàng)目，2.5 萬(wàn)，2010.1-2010.12。

8. 肺炎鏈球菌錳轉(zhuǎn)運(yùn)機(jī)制的研究（51208047）。暨南大學(xué)引進(jìn)人才啟動(dòng)基金，4 萬(wàn)，2008.5-2010.5。

9. 化膿鏈球菌中轉(zhuǎn)鐵蛋白MtsA和HtsA金屬結(jié)合特性的研究 。211工程三期預(yù)研項(xiàng)目，4萬(wàn)，2008.12-2009.12。

榮譽(yù)與獎(jiǎng)勵(lì)：

1. 廣東省“千百十”工程校級(jí)培養(yǎng)對(duì)象，2010。

2. 廣州市珠江科技新星，2011。