概述
,男,1972年生,藥物化學(xué)博士,副教授,天然藥物化學(xué)教研室副主任。碩士研究生導(dǎo)師,天然藥物化學(xué)教研室副主任,貴陽(yáng)醫(yī)學(xué)院骨干教師,中央組織部第八批“西部之光”訪問(wèn)學(xué)者。1995年畢業(yè)于北京師范大學(xué)化學(xué)系,獲理學(xué)學(xué)士學(xué)位;1995-2002年在貴陽(yáng)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院工作;2007年畢業(yè)于中國(guó)科學(xué)院上海藥物研究所,獲藥物化學(xué)博士學(xué)位。2007年7月轉(zhuǎn)入貴陽(yáng)醫(yī)學(xué)院藥學(xué)院工作,2008年12月晉升為副教授。在貴陽(yáng)醫(yī)學(xué)院藥學(xué)院主講有本科生的《天然藥物化學(xué)》、《波譜解析》課程,并專為研究生開(kāi)設(shè)有《有機(jī)化合物的結(jié)構(gòu)鑒定》、《波譜和色譜技術(shù)在藥物研發(fā)中的應(yīng)用》、《天然藥化前沿討論與英文論文撰寫》等課程。主要研究方向:天然藥物化學(xué);中藥、民族藥藥效物質(zhì)基礎(chǔ)及其質(zhì)量控制方法;中藥、民族藥產(chǎn)品開(kāi)發(fā);代謝組學(xué)。重點(diǎn)是利用現(xiàn)代波譜和色譜技術(shù)并結(jié)合藥理研究開(kāi)展中藥、民族藥的基礎(chǔ)與應(yīng)用開(kāi)發(fā)研究。曾參與國(guó)家自然科學(xué)基金杰出青年基金“治療重要疾病藥物的天然先導(dǎo)結(jié)構(gòu)的發(fā)展和研究”(30025044),科技部973項(xiàng)目“基于生物信息學(xué)的藥物新靶標(biāo)的發(fā)現(xiàn)和功能研究”子課題“以中草藥有效成分為探針發(fā)現(xiàn)和驗(yàn)證藥物靶標(biāo)”(2002CB512807),國(guó)家自然科學(xué)基金重大項(xiàng)目“新骨架和新結(jié)構(gòu)活性天然產(chǎn)物的發(fā)現(xiàn)與研究(30630072)”,國(guó)際科技合作項(xiàng)目“燈盞細(xì)辛有效物質(zhì)及作用機(jī)理研究(2006DFA33530)”、國(guó)家科技重大專項(xiàng)“注射用復(fù)方葒草凍干粉針I(yè)II期臨床研究及新藥注冊(cè)申報(bào)(2008ZX09101-021)”、貴州省科學(xué)技術(shù)廳“貴州省藥物制劑重點(diǎn)實(shí)驗(yàn)室(黔科合Z字[2009]4001號(hào))”、貴陽(yáng)市科學(xué)技術(shù)計(jì)劃“貴州省中藥民族藥研究開(kāi)發(fā)中心[2009]筑科4合同字第9-3-04號(hào))”、以及貴州省科技廳工業(yè)攻關(guān)項(xiàng)目“燈盞乙素衍生物的制備與工藝優(yōu)化貴州地產(chǎn)藥材葒草產(chǎn)業(yè)化開(kāi)發(fā)應(yīng)用”等項(xiàng)目。主持有國(guó)家自然科學(xué)基金項(xiàng)目“基于體內(nèi)直接作用物質(zhì)的頭花蓼治療泌尿系統(tǒng)感染的物質(zhì)基礎(chǔ)研究(H2803/81160516)”、“蓑衣蓮?fù)谋8巫饔眉捌渥饔脵C(jī)制研究”,貴州省優(yōu)秀科技教育人才省長(zhǎng)資金項(xiàng)目“開(kāi)展苗藥頭花蓼的抗菌物質(zhì)基礎(chǔ)及作用機(jī)理研究,探索構(gòu)建高效率的藥學(xué)人才培養(yǎng)模式”、貴州省科技廳社會(huì)發(fā)展攻關(guān)項(xiàng)目“基于代謝組學(xué)技術(shù)的膀胱癌多生物標(biāo)志物的發(fā)現(xiàn)及其應(yīng)用”(黔科合SY字[2012]3095號(hào))、貴州省教育廳自然科學(xué)研究項(xiàng)目“苗藥頭花蓼治療泌尿系統(tǒng)感染的物質(zhì)基礎(chǔ)研究”(黔教科2007028號(hào))、貴州省科技廳科學(xué)技術(shù)基金項(xiàng)目“南川斑鳩菊的化學(xué)成分及其抗腫瘤活性研究”(黔科合J字[2008]2139號(hào))、貴陽(yáng)市中藥現(xiàn)代化項(xiàng)目“太子參藥效物質(zhì)基礎(chǔ)與質(zhì)量規(guī)范化研究”和貴陽(yáng)市現(xiàn)代藥業(yè)計(jì)劃項(xiàng)目“黔產(chǎn)血人參、小葉黃楊的有效組分與質(zhì)量標(biāo)準(zhǔn)提升研究”。目前正在參與教育部科學(xué)技術(shù)司“民族藥中藥開(kāi)發(fā)應(yīng)用教育部工程研究中心”、貴州省科技廳中藥現(xiàn)代化項(xiàng)目“藍(lán)布正等苗藥的質(zhì)量控制及有效部位研究”(黔科合中藥字[2010]5026號(hào))、貴州省中藥現(xiàn)代化項(xiàng)目“白及質(zhì)量控制技術(shù)與品質(zhì)評(píng)價(jià)研究”等項(xiàng)目的研究工作。同時(shí)參與多項(xiàng)企業(yè)橫向課題研究。
科研成果
發(fā)表的論文與申請(qǐng)的專利目前已在Chemical Reviews,Organic Letters,Tetrahedron,?Journal of Natural Products, Rapid Communications in Mass Spectrometry以及Helvetica Chimica Acta等國(guó)際著名專業(yè)雜志上發(fā)表SCI論文20篇,在國(guó)內(nèi)雜志上發(fā)表論文3篇,申請(qǐng)專利4項(xiàng)。?發(fā)表的相關(guān)研究論文: [1]Liao, Shang-Gao;?Chen, Hua-Dong; Yue, Jian-Min. Plant Orthoesters,Chemical Reviews,?2009. 109 (3), 1092u20131140. [2]?Liao, Shang-Gao; Yuan, Tao; Zhang, Chen; Yang, Sheng-Ping; Wu, Yan; Yue, Jian-Min. Cinnacassides A-E, Five Geranylphenylacetate Glycosides from?Cinnamomum cassia.?Tetrahedron?2009,?65: 883-887. [3]?Liao, Shang-Gao;Zhan, Zha-Jun;Yang, Sheng-Ping;Yue, Jian-Min. Lathyranoic Acid A: First Secolathyrane Diterpenoid in Nature from?Euphorbia lathyris,?Organic Letters?2005,?7?(7): 1379-1382. [4]?Liao, Shang-Gao;?Yang, Sheng-Ping; Yuan, Tao; Zhang, Chuan-Rui; Chen, Hua-Dong; Wu, Yan; Xu, You-Kai; Yue, Jian-Min. Limonoids from the Leaves and Stems of?Toona ciliata,Journal of Natural Products?2007,?70?(8):1268-1273. [5]?Liao, Shang-Gao; Zhang, Bang-Le; Wu, Yan; Yue, Jian-Min. New Phenolic Components from?Daphne giraldii,Helvetica Chimica Acta?2005,?88?(11): 2873-2878. [6]?Liao, Shang-Gao; Wu, Yan; Yue, Jian-Min. Lignans from?Wikstroemia hainanensis,Helvetica Chimica Acta?2006,?89?(1): 73-80. [7]?Shang-Gao Liao, Li-Juan Zhang, Cui-Bin Li, Yan-Yu Lan, Ai-Min Wang, Yong-Juan Li, Xun He, Yong Huang, Xiao-Lan Qi, Zhi-Zhong Guan, Yong-Lin Wang. Rapid screening and characterization of caffeic acid and its esters in?Erigeron breviscapus?by ultra performance liquid chromatography/tandem mass spectrometry.?Rapid Communications in Mass Spectrometry, 2010, 24(17): 2533u20132541.?[8]?Shang-Gao Liao, Li-Juan Zhang, Jin-Juan Zhang, A-Ying Chen, Xiao-Juan Chen, Yue-Ting Li, Li Zuo, Ying Xiong, Yan-Yu Lan, Yong-Jun Li, Ai-Min Wang, Xun He, Yong Huang, Wei Ren, Yong-Lin Wang. Anti-bacterial and anti-inflammatory effects of the fractions from?Polygonum capitatum.?Journal of Ethnopharmacology,Revision under review. [9] Zhang, Chuan-Rui; Yang, Sheng-Ping;Liao, Shang-Gao; Wu, Yan; Yue, Jian-Min. Polyoxygenated Cyclohexene Derivatives from?Uvaria rufa,Helvetica Chimica Acta?2006,?89?(7): 1408-1416. [10] Xu,You-Kai; Yang, Sheng-Ping;?Liao, Shang-Gao; Zhang, Hua; Lin, Li-Ping; Ding, Jian; Yue, Jian-Min. Alkaloids from?Gelsemium elegans,Journal of Natural Products?2006,?69?(9): 1347-1350. [11] Chen, Hua-Dong; Yang, Sheng-Ping;?Liao, Shang-Gao; Zhang, Chuan-Rui; Yue, Jian-Min. Three New 24-Noroleanane Triterpenoids from?Quercus aliena?var.?acuteserrata,?Helvetica Chimica Acta2006,?89(9): 1971-1977. [12] Yang, Sheng-Ping; Gao, Zhao-Bing; Wang, Fang-Dao;?Liao, Shang-Gao; Chen, Hua-Dong; Zhang, Chuan-Rui; Hu, Guo-Yuan; Yue, Jian-Min. Chlorahololides A and B, Two Potent and Selective Blockers of the Potassium Channel Isolated from?Chloranthus holostegius,Organic Letters?2007,?9(5): 903-906. [13] Yin, Sheng; Wang, Xiao-Ning; Fan, Cheng-Qi;Liao, Shang-Gao; Yue, Jian-Min. The First Limonoid Peroxide in the Meliaceae Family: Walsuronoid A from?Walsura robusta,Organic Letters?2007,?9(12): 2353-2356. [14] Zhang, Chuan-Rui.; Yang, Sheng-Ping.;Liao, Shang-Gao; Fan, Cheng-Qi; Wu, Yan; Yue, Jian-Min. Chuktabularins A-D, Four New Limonoids with Unprecedented Carbon Skeletons from the Stem Bark of?Chukrasia tabularis,Organic Letters?2007,?9(17): 3383-3386. [15] Zhang, Chuan-Rui;Yang, Sheng-Ping;Zhu, Qiao;Liao, Shang-Gao;Wu, Yan;Yue, Jian-Min. Nortriterpenoids from?Chukrasia tabularis?var. velutina.?Journal of Natural Products2007,?70(10): 1616-1619. [16] Yang,Sheng-Ping; Zhang, Chuan-Rui; Chen, Hua-Dong;Liao, Shang-Gao; Yue, Jian-Min. Sesquiterpenoids from?Chloranthus spicatus?(Thunb.) Makino.?Chinese Journal of Chemistry2007,?25(12): 1892-1895. [17] Chen, Hua-Dong; Yang, Sheng-Ping;Liao, Shang-Gao; Zhang, Bo; Wu, Yan; Yue, Jian-Min. Limonoids and Sesquiterpenoids from?Amoora tsangii.?Journal of Natural Products2008,71(1): 93-97. [18] Huo, Jun; Yang, Sheng-Ping; Xie, Bo-Jun.;?Liao, Shang-Gao; Lin, Li-Ping; Ding, Jian; Yue,Jian-Min, Cytotoxic Sesquiterpenoids from?Vernonia bockiana,Journal of Asian Natural Products Research?2008,?10(6):571-575. [19] Yuan, Tao; Yang, Sheng-Ping; Zhang, Hai-Yan;?Liao, Shang-Gao; Wang, Wei; Wu, Yan; Tang, Xi-Can; Yue, Jian-Min. Phenolic compounds with cell protective activity from the fruits of?Livistona chinensis.?Journal of Asian Natural Products Research,?2009?, 11(3):243u2013249. [20] Tao Yuan, Rong-Xiu Zhu, Hua Zhang, Oluwatoyin A. Odeku, Sheng-Ping Yang,?Shang-Gao Liao, and Jian-Min Yue. Structure Determination of Grandifotane A from Khaya grandifoliola by NMR, X-ray Diffraction, and ECD Calculation.?Organic Letters2010, 12(2): 252-255. [21] Yong-Lin Wang, Yong-Jun Li, Ai-Min Wang, Xun He,?Shang-Gao Liao, Yan-Yu Lan. Two new glycosides from?Inula cappa.?Journal of Asian Natural Products Research,?2010, 12(9): 765-769.?[22] 王愛(ài)民,劉智,王海軍,李勇軍,廖尚高,王永林. UPLC測(cè)定雞眼睛藥材中鞣花酸類化合物的含量.?中國(guó)中藥雜志,?2009, 34(24): 3235-3237. [23] 李勇軍,何迅,廖尚高,王愛(ài)民,蘭燕宇,黃勇,王永林. 紫金蓮的化學(xué)對(duì)照品研究.?貴陽(yáng)醫(yī)學(xué)院學(xué)報(bào),2008, 33(6): 622-624. [24] 張麗娟,廖尚高,詹哲浩,陳曉君,蘭燕宇.頭花蓼酚酸類化學(xué)成分研究, 時(shí)珍國(guó)醫(yī)國(guó)藥,2010, 21(8): 1946-1947.?申請(qǐng)的相關(guān)專利: [1]?廖尚高,王永林,張麗娟,蘭燕宇,王愛(ài)民,李勇軍,何迅,黃勇,詹哲浩.頭花蓼總黃酮、總鞣質(zhì)和沒(méi)食子酸類化合物的制備方法,中國(guó)專利,申請(qǐng)?zhí)枺?01010041801.4. [2]?廖尚高,王永林,官志忠,蘭燕宇,鄭林,張麗娟. 液相色譜/串聯(lián)質(zhì)譜聯(lián)用快速篩選和鑒定具有特定結(jié)構(gòu)的化合物。申請(qǐng)?zhí)枺?01010213261.3 [3] 王永林, 官志忠, 鄭 林, 齊曉嵐, 蘭燕宇,王愛(ài)民, 李勇軍, 何 迅, 黃勇,?廖尚高, 傅曉鐘, 周雯, 劉童. 燈盞細(xì)辛藥材的質(zhì)量控制方法,中國(guó)專利,申請(qǐng)?zhí)枺?00910102818.3). [4] 王永林, 官志忠, 黃勇, 齊曉嵐, 鄭林, 蘭燕宇, 王愛(ài)民, 李勇軍, 何迅,?廖尚高, 傅曉鐘, 周雯, 劉童. 一種具有腦神經(jīng)保護(hù)作用的燈盞細(xì)辛活性成分篩選方法,中國(guó)專利,申請(qǐng)?zhí)枺?00910102817.9.?獲獎(jiǎng)情況(均為第一獲獎(jiǎng)人): [1] 上海市浦東新區(qū)第五屆優(yōu)秀科技論文一等獎(jiǎng)[Plant Orthoesters(植物原酸酯)]. [2] 中國(guó)科學(xué)院上海藥物研究所2005年度研究生優(yōu)秀論文二等獎(jiǎng).