梁朋四川大學(xué)生命科學(xué)學(xué)院教授博導(dǎo)北京大學(xué)生物系學(xué)士，美國(guó)伊利諾斯大學(xué)生物化學(xué)博士，美國(guó)哈佛大學(xué)醫(yī)學(xué)院 Dana-Farber癌癥研究所博士后，美國(guó) Vanderbilt大學(xué)終身教授。是基因差異顯示技術(shù)和蛋白質(zhì)三聚體化技術(shù)的發(fā)明人、白介素24(IL-24)及受體的發(fā)現(xiàn)者、p53靶基因 Killin，NDRG1，CYFIP2和TIS11D的發(fā)現(xiàn)者，擁有10項(xiàng)已授權(quán)的美國(guó)專(zhuān)利。1997年獲北美華人生物學(xué)家年會(huì)(SCBA)頒發(fā)的“科技發(fā)明大獎(jiǎng)”，1998年獲德國(guó)分子生物學(xué)和生物化學(xué)協(xié)會(huì)頒發(fā)的“分子分析大獎(jiǎng)”。

美國(guó)Vanderbilt(范德堡)大學(xué)終身教授 (Associate professor)

GenHunter公司 (美國(guó)) 創(chuàng)始人及董事長(zhǎng)

四川三葉草生物制藥公司創(chuàng)始人及董事長(zhǎng)

四川大學(xué)生命科學(xué)學(xué)院教授

成都市第四屆科技顧問(wèn)團(tuán)顧問(wèn)

1978.7-1982.8北京大學(xué)生物系 學(xué)士

1983 CUSBEA中美交換計(jì)劃 留美學(xué)生

1984.1-1990.1 美國(guó)伊利諾斯大學(xué)生物化學(xué) 博士

1991.4-1995.8 美國(guó)哈佛大學(xué)醫(yī)學(xué)院 Dana-Farber癌癥研究所 博士后

1995.9-1999.7美國(guó)Vanderbilt(范德堡)大學(xué)助理教授（Assistant Professsor）

1999.8-2010.12.31 美國(guó)Vanderbilt(范德堡)大學(xué)終身教授 (Associate Professor)

1992.10-至今 GenHunter公司 (美國(guó)) 創(chuàng)始人及董事長(zhǎng)

2007.6-至今 四川三葉草生物制藥公司 創(chuàng)始人及董事長(zhǎng)

2007.12-至今 國(guó)家生命科學(xué)與技術(shù)人才培養(yǎng)基地（四川三葉草生物制藥有限公司與四川大學(xué)生命科學(xué)學(xué)院共建）主任

2007.9-2010.7 四川大學(xué) 客座教授

2007.9-2010.7 四川大學(xué)生命科學(xué)學(xué)院兼職教授

2008.5-至今 成都市第四屆科技顧問(wèn)團(tuán) 顧問(wèn)

2010.8-至今 四川大學(xué) 教授

癌癥及自身免疫性疾�。ㄈ缗Ｆぐ_及關(guān)節(jié)炎）等的發(fā)病分子基理及治療手段。

本實(shí)驗(yàn)室以運(yùn)用世界上最先進(jìn)的熒光基因表達(dá)差異顯示（FDD）技術(shù)為手段，尋找及發(fā)現(xiàn)疾病相關(guān)的靶基因，用生物化學(xué)及細(xì)胞生物學(xué)的方法對(duì)其進(jìn)行功能性研究。用AP-Tag技術(shù)尋找及研究相關(guān)的分泌型細(xì)胞因子及其細(xì)胞表面受體，并運(yùn)用現(xiàn)代生物邏輯制藥的方法（包括本實(shí)驗(yàn)室發(fā)明的蛋白質(zhì)三聚體化技術(shù)），在生物反應(yīng)器中采用無(wú)血清細(xì)胞培養(yǎng)技術(shù)研發(fā)生產(chǎn)新一代癌癥及自身免疫性疾病的靶向抗體及可溶性受體蛋白質(zhì)藥物。

（1）科技部科技型中小企業(yè)技術(shù)創(chuàng)新基金項(xiàng)目：《重組人TNF-α可溶性受體及膠原蛋白三聚體融合蛋白藥物(SCB-131)的開(kāi)發(fā)》

（2） 四川省科技支撐計(jì)劃項(xiàng)目:《重組人腫瘤壞死因子相關(guān)凋亡誘導(dǎo)配體(TRAIL)三聚體融合蛋白(SCB-313)的研究》

（3）成都市科技攻關(guān)計(jì)劃：《重組人可溶性RANK配體抑制劑三聚體融合蛋白抗骨質(zhì)疏松藥物的研發(fā)》

在《科學(xué)》、《自然生物技術(shù)》、《自然方法學(xué)》、《自然癌癥綜述》、《美國(guó)國(guó)家科學(xué)院院士通報(bào)》和《酶學(xué)方法》等世界著名雜志上發(fā)表的文獻(xiàn)近70篇，其ISI引用率超過(guò)9000次。

(1) Man Qiao, Dan Luo, Yi Kuang, Haiyan Feng, Guangping Luo andPeng Liang.Cell Cycle Specific Distribution of Killin: Evidence for Negative Regulation of both DNA and RNA Synthesis.Cell Cycle,2015, in Press.

(2)Xinxin Liu, Anliang Huang, Dan Luo, Haipeng Liu, Huzi Han, Yang Xu,Peng Liang.Use of adenylate kinase as a solubility tag for high level expression of T4 DNA ligase in Escherichia coliProtein Expression and Purification.2015 Feb; 109 :79u201384.

(3) Ma Z,Luo D,Huang A,Xu Y,Wang Y,Wei Y,Liang P.pKILLIN: a versatile positive-selection cloning vector based on the toxicity of Killin in Escherichia coli.Gene.2014 Jul 10; 544(2):228-35.

(4) Cho YJ,Liang P.S-phase-coupled apoptosis in tumor suppression.Cell Mol LifeSci. 2011 Jun;68(11):1883-96.

(5) He M,Liang P.IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis.J Immunol.2010 Feb 15;184(4):1793-8.

(6) Cho YJ, Meade JD, Shester BR, Walden JC, Guo Z,Liang P.Linear dynamic range for signal detection in fluorescent differential display.Biotechnol Lett.2010 Nov;32(11):1593-7.

(7) Cho YJ, Meade JD, Shester BR, Walden JC, Guo Z,Liang P.Proof-reading signal accuracy of gene expression by binary differential display.Biotechnol Lett.2010 Aug;32(8):1039-44.

(8) Meade JD,Cho YJ,Shester BR,Walden JC,Guo Z,Liang P.Automated fluorescent differential display for cancer gene profiling.Methods Mol Biol.2010;576:99-133.

(9) S. Zhou,J.D. Meade,S. Nathashon,B. Shester,J. Walden,Z. Guo,J.Z. Liang,J. G. Liang andP. Liang.: Genome-Wide Analysis of mRNA Expression by Florescent Differential Display.The Handbook of Plant Functional Genomics.p165-186. 2008. Wiley-Blackwell publisher.

(10) Cho YJ,Liang P.Killin is a p53-regulated nuclear inhibitor of DNA synthesis.Proc Natl Acad Sci U S A.2008 Apr 8;105(14):5396-401.

(11) Jackson, R., Cho YJ., Stein, S. andLiang, P.: CYFIP2 is a p53 target gene.Cell Cycle.2007 Jan;6(1):95-103.

(12)Liang, P.Meade, J. and Pardee, A.B: "A protocol for differential display of mRNA expression using either fluorescent or radioactive labeling"Nature Protocols.2007, Mar 15, 2:457 - 470.

(13)Liang, P.: MAQC papers over the cracks.Nature Biotechnology.2007 Jan; 25(1): 27-8.

(14) Jackson, R., Cho YJ., andLiang, P.:TIS11D is a Candidate Pro-Apoptotic p53 TargetGene. Cell Cycle.2006 Dec;5(24):2889-2893.

(15)Liang P.:From differential display to DNA microarrays-a personal account.J Cell Physiol.2006 Dec;209(3):653-8.

(16) Tan Z, Wang M,Liang P.: Identification by Differential Display of IL-24 Autocrine Loop Activated by Ras Oncogenes.Methods Mol Biol.2005;317:207-18.

(17) Meade JD, Cho YJ, Fisher JS, Walden JC, Guo Z,Liang P.: Automation of fluorescent differential display with digital readout.Methods Mol Biol.2005;317:23-58.

(18) Cho YJ, Stein S, Jackson RS,Liang P.:Saturation Screening for p53 Target Genes by Digital Fluorescent Differential Display.Methods Mol Biol.2005;317:179-92.

(19) Yang S,Liang P.: Global analysis of gene expression by differential display: a mathematical model.Methods Mol Biol.2005;317:3-22.

(20) Thomas EK, Nakamura M, Wienke D, Isacke CM, Pozzi A,Liang P.:Endo180 binds to the C-terminal region of alpha 1(I) collagen.J Biol Chem.2005. 280(24):22596-605.

(21) Wang M,Liang P.Interleukin-24 and its receptors.Immunology.2005. 114(2):166-70.

(22)Yang,S. andLiang P.:Global analysis of gene expression by differential display, a mathematical model.Mol Biotechnol.2004. 3:197-208.

(23) Wang, M., Tan,Z., Thomas, E.K. andLiang, P.: Conservation of the genomic structure and receptor-mediated signaling between human and rat IL-24.Genes & Immunity.2004.5:363-70.

(24) Stein,S., Thomas, E.K., Herzog, B., Westfall, M. D., Rocheleau, J.V., Jackson, R., Wang, M. andLiang,P.:NDRG1 is necessary for p53-dependent apoptosis.J.Biol.Chem., 2004. 279(47): 48930-40

(25)Peng Liang& Arthur B. Pardee.: Analysing differential gene expression in cancer.Nature Reviews Cancer2003. 3:869-876.

(26) Stein S, Cho, Y. Jackson R.S. andLiang P.: Identification of p53 target genes by fluorescent differential display.Cell Mol Life Sci.2002 Aug;59(8):1274-9.

(27) Stein S,Liang P.: Differential display analysis of gene expression in mammals: a p53 story.Cell Mol Life Sci.2002 Aug;59(8):1274-9.

(28) Stein J,Liang P.: Differential display technology: a general guide.Cell Mol Life Sci.2002 Aug;59(8):1235-40. Review.

(29)Liang P.: SAGE Genie: A suite with panoramic view of gene expression.Proc.Natl.Acad.Sci.U.S.A.2002. 99:11547-11548.

(30)Liang P.: A decade of differential display.Biotechniques. 2002. 33:338-346.

(31) Cho, Y., Prezioso, V. R. AndLiang, P.: Systematic analysis of intrisince factors affecting differential display.Biotechniques2002, 32:1-4.

(32) Wang, M.,Tan,Z., Zhang, R.,Kotenko, S. V. andLiang, P.: Interleukin-24 (Mob-5/ Mda-7) Signals through Two Heterodimeric Receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.J.Biol.Chem.2002. 277:7341-7347.

(33) Cho, Y., Meade, J., Walden, J., Guo, Z. andLiang, P.: Multi-color Fluorescent Differential Display.Biotechniques2001, 30:562-572.

(34) Jo, H., Cho, Y., Zhang, H. andLiang P.: Differential display analysis of altered gene expression by ras oncogene.Methods in Enzymol.(Academic Press),2001. 332: 233-244.

(35)Liang, P.:Gene Discovery Using Differential Display.Genetic Engineering News.2000. 20:37.

(36)Cho, Y. andLiang, P.: Differential display for detecting potential gene candidates.Molecular Genetics of Mental Disorders, Edited by Briley and Sulser. Martin Dunitz Publishers, London, UK.,2000. In press.

(37)Zhang, R., Tan, Z. andLiang, P.: Identification of a novel ligand-receptor pair constitutively activated by ras oncogene.J. Biol. Chem.2000, 275:24436-24443.

(38) Jo, H., Zhang, R., Zhang, H. McKinsey, T. A. Ballard, D.W. andLiang, P.: NF-kB is required for H-Ras oncogene induced abnormal cell proliferation and tumorigenesis.Oncogene2000, 19:841-849.

(39)Liang, P.and Pardee, A. B.: Differential Display, a generalProtocol Mol Biotechnology.1998, 10:261-267.

(40) Jo, Hakryul, Zhang, H., Zhang, R. andLiang, P.: Cloning oncogenic Ras regulated genes by differential display. Methods -A Companion to Methods in Enzymology, Academic Press, 1998, 16:365-375.

(41)Liang, P.: Factors Ensuring successful use of differential display. Methods --A Companion to Methods in Enzymology, Academic Press, 1998, 16:361-364.

(42) Sheng, H., Williams, C. S., Shao, J.,Liang, P., DuBois, R. N. and Beauchamp, R. D.: Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway.J.Biol.Chem.1998, 273: 22120-22127.

(43) Zha, ng, R., Averboukh, L., Zhu, W., Zhang, H., Jo, H., Dempsey, P.J., Coffey, R., A. B. Pardee andLiang, P.: Identification of rCop-1, a New Member of CCN Gene Family, as a Negative Regulator for Cell Transformation.Mol. Cell. Biol.,1998, 18:6131-6141.

(44) Hu, J., You, S., Li, W., Wang, D., Nagpal, M. L., Mi, Y.,Liang, P.and Lin, Tu.: Expression and regulation of Interferon-g-inducible protein 10 gene in Rat Leydig Cells.Endocrinology1998, 139:3637-3645.

(45)Liang, P., Wang, F., Zhu, W., O’Connell, R. P., and Averboukh, L.: Identification of novel diagnostic markers by differential display.Methods in Molecular Medicine.Humana Press, 1998, p3-13.

(46) Grady, T.,Liang, P., Ernst,S.A.and Logsdon, C. D.: Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis.Gastroenterology1997, 113:1966-1975.

(47)Liang, P.and Pardee, A.B.: Differential display: A general protocol.Methods in Molecular Biology.Humana Press. 1997, Vol. 85, p3-12.

(48) Zhang, R., Zhang, H., Zhu, W., Coffey, R., A. B. Pardee andLiang, P.: Mob-1, a ras target gene, is over expressed in colorectal cancer.Oncogene1997, 14:1607-1610.

(49) Averboukh, L.,Liang, P., Kantoff, P. W. and Pardee, A.B.: Regulation of S100P expression by androgen.Prostate,1996, 29:350-355.

(50) Zhu, W. andLiang, P.: Detection and isolation of differentially expressed genes by differential display.Methods in Molecular Biology, 1996, 68:211-220, Boultwood, J. ed. Humana Press

(51)Liang, P.: Analysis of messenger RNA by differential display.A laboratory guide to RNA,1996, 223-236. Krieg, P.A. ed., Wiley-Liss.

(52) , Wang, F-L., Wang, Y., Wong, W-K., Liu, Y., Addivinola, F. J.,Liang, P., Chen, L-B., Kantoff, P. W. and Pardee, A.B.: Two differentially expressed genes in normal human prostate tissue and in carcinoma.Cancer Res.1996, 56:3634-3637.

(53) Zhang, H., Zhang, R. andLiang, P.: Differential screening of gene expression difference enriched by differential display.Nucleic Acids Res., 1996, 24:2454-2456.

(54) Hu, E.,Liang, P.and Spiegelman, B. M.: AdipoQ is a novel adipose-specific gene dysregulated in obesity.J.Biol Chem.1996, 271:10697-10703.

(55)Liang, P., Averboukh, L., Zhu, W., Wang, F., Haley, T. and Pardee, A. B.: Molecular characterization of Murine thymidylate kinase gene.Cell Growth & Differentiation1995, 6:1333-1338.

(56) Trentmann, S.M., van der Knaap, E., Kende, H.,Liang, P.and Pardee A.B.: Alternatives to 35S as a Label for the differential display of eukaryotic messenger RNA.Science1995, 267: 1186-1187.

(57) Rohrwild, M., Alpan, R.S.,Liang, P.and Pardee, A.B.: Inosine-containing primers for mRNA differential display.Trend in Genet., 1995,11:300.

(58)Liang, P.and Pardee, AB.: Recent Advances in Differential Display.Current Opinion in Immunol.1995, 7:274-280.

(59)Liang, P., Bauer, D., Averboukh, L., Warthoe, P. Rohrwild, M., Muller, H., Strauss, M. and Pardee, A.B.: Analysis of altered gene expression by differential display. in Oncogene Techniques,Methods in Enzymol.(Academic Press),1995, 254:304-321.

(60)Liang, P., Zhu, W., Zhang, X., Guo, Z., Ou2019Connell, R., Averboukh, L. Wang, F. and Pardee, A. B.: Differential display using one-base anchored oligo-dT primer.Nucleic Acids Res., 1994, 22:5763-5764.

(61)Liang, P.and Pardee, A.B., : Differ, ential display of mRNA by PCR. in Current Protocols inMolecular Biology(Wiley Interscience), 1994, Unit 15.8.

(62)Liang, P., Averboukh, L. and Pardee, A. B.: Method of differential display. in Methods inMolecular Genetics(Academic Press), 1994, Vol. 5, pp3-16.

(63)Liang, P., Averboukh, L., Zhu, W. and Pardee, A. B.: Ras activation of novel genes: Mob-1 as a model.Proc Natl Acad.Sci U S.A.,1994, 91:12515-12519.

(64) Barry M. B., Meador, B., Builerback, T.,Liang, P., Glaser, M. and Philips, G. N., Jr.: The closed conformation of a highly flexible protein: the structure of E. coli adenylate kinase with bound AMP and AMPPNP.Proteins1994, 19:183-198.

(65) Russell, M. E., Utans, U., Wallace, A. F.,Liang, P., Karnovsky, M. J., Wyner, L. R., Yamshita, Y. and Chi, T.: Upregulation of Gal/GalNAc macrophage lectin in chronically rejecting rat cardiac allografts with arteriosclerosis.J.Clin.Invest.,1994, 94:722-730.

(66) Utans, U.,Liang, P., Wyner, L. R., Karnovsky, M. J. and Russell, M. E.: Chronic cardiac rejection: Identification of five upregulated genes in transplanted hearts by differential mRNA display.Proc.Natl.Acad.Sci.U.S.A.1994, 91:6463-6467.

(67) Sager, R., Anisowicz, A., Neveu, M.,Liang, P.and Sotiropoulou, G.: Identification by differential display of alpha 6 integrin as a candidate tumor suppressor gene.FASEB J.1993, 7:964-970.

(68)Liang, P., Averboukh, L. and Pardee, A. B.: Distribution and cloning of eukayotic mRNAs by means of differential display: refinements and optimization.Nucleic Acids Res.1993, 21:3269 -3275.

(69)Liang, P.Averboukh, L., Keyomarsi, K., Sager, R. and Pardee, A.B.: Differential display and cloning of mRNAs from human breast cancer vs. mammary epithelial cells.Cancer Research1992, 52:6966-6968.

(70)Liang, P.and Pardee, A. B.: Differential display of eukaryotic mRNA by means of the polymerase chain reaction.Science1992, 257:967-971.

(71)Liang, P., Phillips Jr., G. N. and Glaser, M.: Assignment of nucleotide binding sites and the mechanism of substrate inhibition of Escherichia coli adenylate kinase.Proteins1991, 9:28-36.

(72)Liang, P.and Glaser, M.: Efficient cloning of a mutant adenylate-kinase-encoding gene from Escherichia coli.Gene1990, 80:21-28.

(73) Althoff, S., Zambrowicx, B.,Liang, P., Glaser, M. and Phillips Jr., G. N.: Crystalization and preliminary X-ray analysis of Escherichia coli adenylate kinase.J. Mol. Biol.1988, 199:665-666.

(74)Liang, P.and Glaser, M.: Rapid recovery and Identification of a temperature- sensitive adenylate kinase gene from Escherichia coli.J.Cell Biol.1988, 107:306a.

編著：

（1）Liang, P.

and Pardee, A.B.: 《Differential display Methods and Protocols》.Methods in Molecular Biology，Vol. 85, Humana Press. 1979

（2）Liang, P.: 《Current progress in differential display methods and applications》.Methods-- A Companion to Methods in Enzymology, Academic Press, Vol. 16. 1998

（3）Liang, P.

Meade, JD and Pardee, A.B.:《Differential Display Methods and Protocols》.2nd Edition.

Methods in Molecular Biology,Vol. 317, Humana Press. 2005.

獲獎(jiǎng)：

1997 獲一年一度的北美華人生物學(xué)家年會(huì)頒發(fā)的“科技發(fā)明大獎(jiǎng)”

1998 獲二年一度的德國(guó)分子生物學(xué)和生物化學(xué)協(xié)會(huì)頒發(fā)的“分子分析大獎(jiǎng)”

2009 四川省第一批“百人計(jì)劃”入選者

2009 國(guó)務(wù)院僑辦“重點(diǎn)華僑華人創(chuàng)業(yè)團(tuán)隊(duì)”獲得者

2009 國(guó)務(wù)院僑辦頒布的第二屆百名華僑華人專(zhuān)業(yè)人士“杰出創(chuàng)業(yè)獎(jiǎng)”

專(zhuān)利：

（A）基因差異顯示 (Differential Display) 技術(shù)發(fā)明（四項(xiàng)美國(guó)專(zhuān)利）

1993-11-16，Arthur Pardee,Liang Peng；Identifying, isolating and cloning messenger RNAs；USA；5, 262, 311

1997-2-4，Liang Peng，Arthur Pardee；Methods of differential display of exposed mRNA by RT/PCR；USA；5, 599, 672

1997-9-9，Arthur Pardee,Liang Peng；Methods of Comparing Levels or Amount of mRNAs；USA；5, 665,547

1999-8-12，Arthur Pardee,Liang Peng；System for Comparing level or amounts of mRNA；USA；5,965,409

（B）蛋白質(zhì)三聚體化（Trimer-Tag）技術(shù)發(fā)明（三項(xiàng)美國(guó)專(zhuān)利）

2007-9-11，Liang Peng；Methods and Compositions For Producing Secreted Trimeric Receptor Analogs And Biologically Active Fusion Proteins；USA；7,268,116

2010-2-23，Liang Peng；Methods and Compositions For Producing Secreted Trimeric Receptor Analogs And Biologically Active Fusion Proteins；USA；7,666,837

2010-4-6，Liang Peng；Methods for Blocking TNF-alpha Activity in Mammals with Trimeric Soluble TNF Receptors；USA；7,691,815

（C）白介素24（IL-24）和白介素24受體（IL-24 receptors）發(fā)現(xiàn)（二項(xiàng)美國(guó)專(zhuān)利）

2005-6-7，Liang Peng；Human Mob-5 (IL-24) receptors and uses thereof；USA；6,902,930

2007-8-2，Liang Peng；Human Mob-5 (IL-24) receptors and uses thereof；USA；7,276,237

（D）p53靶基因Killin 發(fā)現(xiàn)（一項(xiàng)美國(guó)專(zhuān)利）

2009-8-8，Liang Peng,Yongjig Cho；Tumor suppressor Killin；USA；7,576,191