人物經(jīng)歷
2010年至今:華東師范大學(xué), 生命科學(xué)學(xué)院, 教授, 博士生導(dǎo)師;
2009年:圣路易斯華盛頓大學(xué), 生物醫(yī)學(xué)工程系, 博士后研究助理;
2004-2008年:中國科學(xué)技術(shù)大學(xué), 生命科學(xué)學(xué)院, 獲得結(jié)構(gòu)生物學(xué)博士學(xué)位;
2000-2004年: 中國科學(xué)技術(shù)大學(xué), 高分子科學(xué)與工程系, 獲得理學(xué)學(xué)士學(xué)位。
研究方向
樹枝形分子等生物材料的設(shè)計及其在生物醫(yī)學(xué)中的應(yīng)用研究;
納米生物材料在早期癌癥診斷及靶向治療中的應(yīng)用研究;
基于樹枝形分子的主-客體系統(tǒng)的設(shè)計及其在藥物運輸中的應(yīng)用;
生物兼容的納米材料在早期腫瘤診斷及治療中的應(yīng)用研究;
將多維核磁等技術(shù)應(yīng)用于納米藥物劑型設(shè)計及優(yōu)化的研究。
社會兼職
2010年起擔(dān)任國際刊物Current Drug Discovery Technologies的Regional Editoru201a曾擔(dān)任Open Journal of Pharmacologyu201a Current Drug Discovery Technologiesu201a Der Pharma Chemicau201a Local and Regional Anesthesia 等多個國際刊物編委(Editorial Board Member)u201a 先后70多次被邀請為30多個國際知名刊物的審稿人。
國際刊物、出版物編輯 (Editors):
2010年至今: Current Drug Discovery Technologies (Regional Editor);
2010年: 應(yīng)著名出版公司John Wiley & Sons, Inc.邀請擔(dān)任“Dendrimer-based Drug Delivery Systems: From Theory to Practice”一書的主編(Editor-in chief)。
國際刊物編委 (Editorial Board Members):
2009年至今: Open Journal of Pharmacology;
2008年至今: Local and Regional Anesthesia;
2009-2010年: Current Drug Discovery Technologies;
2009年至今: Der Pharma Chemica.
主要成果
自開展研究工作起一直致力于樹枝形分子等納米生物材料的研究工作,已經(jīng)在Nature Materialsu201a Chemical Society Reviews, Journal of the American Chemical Societyu201a Journal of Physical Chemistry B等國際知名刊物發(fā)表第一作者/通訊作者SCI論文30多篇u201a論文影響因子總和達(dá)160,被制藥科學(xué)和藥物化學(xué)領(lǐng)域知名刊物Chemical Society Reviews, Frontiers in Bioscienceu201a Journal of Pharmaceutical Sciencesu201a European Journal of Medicinal Chemistry等邀請撰寫專題綜述6篇,所發(fā)表第一/通訊作者論文已有7篇(次)被雜志選為出版當(dāng)年、當(dāng)季度的熱門或引用次數(shù)最多的文章。
在樹枝形分子領(lǐng)域的很多工作已經(jīng)受到國際同行專家的認(rèn)可和關(guān)注,被國際著名出版社John Wiley & Sons 邀請作為主編編寫專題著作“Dendrimer-based Drug Delivery Systems: from Theory to Practice”(2011年正式出版),論文被國內(nèi)外其他課題組公開引用500多次。近3年代表性論文如下:(*通訊作者)
1) Yavuz MSu2020u201a Cheng YYu2020u201a Chen JYu2020u201a Cobley CMu201a Zhang Qu201a Rycenga Mu201a Xie JWu201a Kim Cu201a Schwartz AGu201a Wang LVu201a Xia YN*u201a Gold Nanocages Covered by Smart Polymers for Controlled Release with Near-infrared Light. Nature Materialsu201a 2009u201a 8(12): 935-939. (u2020共同第一作者; 2009年影響因子29.504; 論文自發(fā)表以來被 Science Dailyu201a The New York Timesu201a R & D Magazinesu201a Nanomedicine等多家權(quán)威媒體u201a雜志Highlight).
2) Zhao LBu201a Wu QLu201a Cheng YY*u201a Zhang JHu201a Wu JHu201a Xu TW*. High-Throughput Screening of Dendrimer-Binding Drugsu201a Journal of the American Chemical Societyu201a 2010u201a 132(38): 13182-13184u201a 2010. (2009年影響因子8.58).
3) Feng XYu201a Cheng YY*u201a Yang Ku201a Zhang Ju201a Wu Qu201a Xu TW*. Host-Guest Chemistry of Dendrimer-Drug Complexesu201a 5. Insights into the Design of Formulations for Noninvasive Delivery of Heparin Revealed by Isothermal Titration Calorimetry and NMR Studiesu201a Journal of Physical Chemistry Bu201a 2010u201a 114 (34): 11017-11026.
4) Cheng YY*u201a Xu ZHu201a Ma MLu201a Xu TW*u201a Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administrationu201a Journal of Pharmaceutical Sciencesu201a 2008u201a 97(1): 123-143. (2008年被選為該雜志十大最熱門文章之一; 2009年再次被選為該雜志十大被引次數(shù)最多的文章).
5) Fang Mu201a Cheng YY*u201a Zhang JHu201a Wu QLu201a Hu JJu201a Zhao LBu201a Xu TW*u201a New Insights into the Interactions between Dendrimers and Surfactants: 4. Fast Exchange/Slow Exchange Transitions in the Structure of Dendrimer-Surfactant Aggregatesu201a Journal of Physical Chemistry Bu201a 2010u201a 114(18): 6048-6055.
6) Yang Ku201a Cheng YY*u201a Feng XYu201a Zhang JHu201a Wu QLu201a Xu TW*u201a New Insights into the Interactions between Dendrimers and Mixed Micelles: 5. Formation of Miscellaneous Mixed Micelles Revealed by a Combination of 1H NMRu201a Diffusionu201a and NOE Analysisu201a Journal of Physical Chemistry Bu201a 2010u201a 114(21): 7265-7273.
7) Hu JJu201a Fang Mu201a Cheng YY*u201a Zhang JHu201a Wu QLu201a Xu TWu201a Host-Guest Chemistry of Dendrimer-Drug Complexes: 4. An In-depth Look into the Binding/Encapsulation of Guanosine Monophosphate by Dendrimersu201a Journal of Physical Chemistry Bu201a 2010u201a 114(21): 7148-7157.
8) Cheng YY*u201a Wu QLu201a Li YWu201a and Xu TW*u201a External Electrostatic Interaction versus Internal Encapsulation between Cationic Dendrimers and Negatively Charged Drugs: Which Contributes More to Solubility Enhancement of the Drugs? Journal of Physical Chemistry Bu201a 2008u201a 112: 8884-8890.
9) Hu JJu201a Cheng YY*u201a Wu QLu201a Zhao LBu201a Xu TW*u201a Host-Guest Chemistry of Dendrimer-Drug Complexes: 2. Effects of Molecular Properties of Guests and Surface Functionalities of Dendrimersu201a Journal of Physical Chemistry Bu201a 2009u201a 113(31): 10650 - 10659.
10) Zhao LBu201a Cheng YY*u201a Hu JJu201a Wu QLu201a Xu TW*u201a Host-Guest Chemistry of Dendrimer-Drug Complexes: 3. Competitive Binding of Multi-drugs to a Single Dendrimeru201a Journal of Physical Chemistry Bu201a 2009u201a 113(43): 14172-14179.
11) Cheng YY*u201a Li YWu201a Wu QLu201a Xu TW*u201a New Insights into the Interactions between Dendrimers and Surfactants by Two Dimensional NOE NMR Spectroscopyu201a Journal of Physical Chemistry Bu201a 2008u201a 112(40): 12674-12680.
12) Hu JJu201a Cheng YY*u201a Ma YRu201a Wu QLu201a Xu TW*u201a Host-Guest Chemistry and Physico-chemical Properties of Dendrimer-Mycophenolic Acid Complexesu201a Journal of Physical Chemistry Bu201a 2009u201a 113(1): 64-74.
13) Cheng YY*u201a Wu QLu201a Li YWu201a Hu JJu201a Xu TW*u201a New Insights into the Interactions between Dendrimers and Surfactants: 2. Design of New Drug Formulations Based on Dendrimer-Surfactant Aggregatesu201a Journal of Physical Chemistry Bu201a 2009u201a 113(24): 8339-8346.
14) Wu QLu201a Cheng YY*u201a Hu JJu201a Zhao LBu201a Xu TW*u201a New Insights into the Interactions between Dendrimers and Surfactants: 3. Size- and Hydrophobicity-Dependent Encapsulation of Bile Saltsu201a Journal of Physical Chemistry Bu201a 2009u201a 113: 12934-12943.
15) Cheng YYu201a Wang JRu201a Rao TLu201a He XXu201a Xu TW*u201a Pharmaceutical Applications of Dendrimers: Promising Nanocarriers for Drug Deliveryu201a Frontiers in Bioscienceu201a 2008u201a 13: 1447-1471.
16) Yang WJu201a Li YWu201a Cheng YY*u201a Wu QLu201a Wen LPu201a Xu TW*u201a Evaluation of Phenylbutazone and Poly(amidoamine) Dendrimers Interactions by a Combination of Solubilityu201a 2D-NOESY NMRu201a and Isothermal Titration Calorimetry Studiesu201a Journal of Pharmaceutical Sciencesu201a 2009u201a 98(3): 1075-1085.
17) Cheng YY*u2020u201a Li YWu2020u201a Wu QLu201a Zhang JHu201a Xu TW*u201a Generation-Dependent Encapsulation/Electrostatic Attachment of Phenobarbital Molecules by Poly(amidoamine) Dendrimers: Evidence from 2D-NOESY Investigationsu201a European Journal of Medicinal Chemistryu201a 2009u201a 44(5): 2219-2213. (u2020共同第一作者).
18) Yang WJu201a Cheng YY*u201a Xu TW*u201a Wang XYu201a Wen LP*u201a Targeting Cancer Cells with Dendrimer-Biotin Conjugatesu201a European Journal of Medicinal Chemistryu201a 2009u201a 44(2): 862-868.
19) Cheng YY*u201a Xu TW*u201a The Effect of Dendrimers on the Pharmacodynamic and Pharmacokinetic behaviors of Non-covalently or Covalently Attached Drugsu201a European Journal of Medicinal Chemistryu201a 2008u201a 43: 2291-2297.
20) Cheng YY*u201a Man Nu201a Xu TWu201a Fu RQu201a Wang XYu201a Wang XMu201a Wen LP*u201a Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs Mediated by Polyamidoamine (PAMAM) Dendrimersu201a Journal of Pharmaceutical Sciencesu201a 2007u201a 96(3): 595-602.