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  • 錢旭紅

    錢旭紅

    錢旭紅(1962年——),男,江蘇寶應(yīng)人,博導(dǎo)、教授、“973”首席科學(xué)家、中國工程院院士、國家自然科學(xué)基金化學(xué)部咨詢委員、英國皇家化學(xué)會會士、德國洪堡基金會學(xué)術(shù)大使,現(xiàn)任華東師范大學(xué)校長。

    長期從事有機(jī)化工領(lǐng)域的應(yīng)用基礎(chǔ)與工程技術(shù)研究和開發(fā)工作。以氟化和芳雜化為主線,深入開展了含特殊官能團(tuán)、活性功能團(tuán)有機(jī)化學(xué)品的分子設(shè)計、合成制備、結(jié)構(gòu)功能及產(chǎn)業(yè)化應(yīng)用。開發(fā)出多氟芳酸等制備的綠色高效關(guān)鍵技術(shù);創(chuàng)制新機(jī)制、性能獨特的順硝烯雜環(huán)類和含氟類綠色化學(xué)農(nóng)藥; 創(chuàng)制分子識別傳感和檢測分離一體化的萘酰亞胺等芳雜環(huán)類熒光功能染料。發(fā)表SCI論文275篇,EI論文64篇;獲得中國發(fā)明專利19項、國際PCT專利和美、歐、日專利共12項。若干技術(shù)實現(xiàn)產(chǎn)業(yè)化或工業(yè)化實施,取得顯著的社會經(jīng)濟(jì)效益。 研究成果(第一完成人)獲得國家科技進(jìn)步二等獎1項、上海市自然科學(xué)一等獎1項、教育部科技進(jìn)步一等獎3項。

    2011年當(dāng)選為中國工程院院士。


    人物履歷

    1978.9 進(jìn)入華東化工學(xué)院(現(xiàn)華東理工大學(xué))石油化工系,1982.7 獲學(xué)士學(xué)位;

    1982.9 華東化工學(xué)院(現(xiàn)華東理工大學(xué))精細(xì)化工系研究生,1985.4 獲碩士學(xué)位;

    1988.7 華東理工大學(xué)獲工學(xué)博士學(xué)位;

    1989.8-1990.8 受美國Welch基金會資助,到美國德克薩斯州拉瑪大學(xué)Research Associate,從事博士后研究,期間他從事了昆蟲生長調(diào)節(jié)劑的研究工作;

    1990.9-1991.12 德國巴伐利亞州維爾茲堡大學(xué)洪堡基金(AvH)博士后,從事DNA嵌入劑、切斷荊的研究;

    錢旭紅

    1988-1992.4 華東理工大學(xué)講師;

    1992.8-1994.7 副教授;1994.8至今,教授;

    1995.12至今,博士生導(dǎo)師。

    1986-1987華東理工大學(xué)精細(xì)化工系黨總支副書記;

    1992.8-1995.4先后任華東理工大學(xué)精細(xì)化工學(xué)科主任、藥物化工研究所所長;

    1995.5-7國家高級教育行政學(xué)院學(xué)員;

    1995.9-1996.2任華東理工大學(xué)校長助理;

    1996.3-2000.10 任華東理工大學(xué)副校長;

    2002.1-2010.1上海市化學(xué)生物學(xué)重點實驗室主任(兼);

    2003.3-2006國家南方農(nóng)藥創(chuàng)制中心(上海)主任(兼)。

    2004.7-2015.3華東理工大學(xué)校長。

    2007.4- 中國化工學(xué)會副理事長;

    2007-2008,亞洲及太平洋化工聯(lián)盟主席。

    2018.1-?華東師范大學(xué)校長

    2011.12 當(dāng)選中國工程院院士(化工、冶金與材料工程學(xué)部)。

    2018年1月,華東師范大學(xué)校長、黨委委員、常委、黨委副書記。

    2020年10月,擔(dān)任教育部基礎(chǔ)教育教學(xué)指導(dǎo)委員會委員。

    任免信息

    2018年1月17日,華東師范大學(xué)召開學(xué)校干部大會,宣布教育部關(guān)于華東師范大學(xué)校長的任免決定:錢旭紅擔(dān)任校長。

    研究課題

    研究方向

    錢旭紅主要研究方向,包括:是生物有機(jī)化學(xué),化學(xué)生物技術(shù)與工程,其研究工作主要體現(xiàn)在用作農(nóng)藥先導(dǎo)、熒光傳感器、抗癌先導(dǎo)、人工核酸酶、細(xì)胞激活劑的芳香雜環(huán)分子設(shè)計、合成、構(gòu)效關(guān)系及生物應(yīng)用。具體研究方向:

    研究方向1.染料的化學(xué)生物學(xué)

    其研究主要體現(xiàn)在熒光傳感器與抗癌先導(dǎo),包括以下內(nèi)容:

    熒光傳感器:由萘,萘酰亞胺,香豆素,氟硼吡咯,聚合物衍生的高選擇性汞離子銅離子鋅離子銀離子熒光傳感器,某些陰離子熒光傳感器,以及其它的熒光探針,熒光標(biāo)記。

    抗癌先導(dǎo):由硫化合物,噻類芳香雜環(huán),羰酰亞胺,萘酰亞胺,萘內(nèi)酰胺、苯并吲哚酚嗪,吖啶,苊萘醌,苊萘吡咯羰腈,酞菁等衍生的抗癌試劑,BCL蛋白與細(xì)胞調(diào)亡劑,拓?fù)洚悩?gòu)酶抑制劑、光動力治療劑,色素的藥物化學(xué)(抗腫瘤先導(dǎo)、DNA嵌入劑、細(xì)胞調(diào)亡劑)

    研究方向2.農(nóng)藥的化學(xué)與生物學(xué)

    其研究主要體現(xiàn)在芳香雜環(huán)或氟化合物衍生的農(nóng)藥先導(dǎo),包括以下內(nèi)容:

    農(nóng)藥先導(dǎo):昆蟲生長調(diào)節(jié)劑、昆蟲行為調(diào)節(jié)劑、幾丁質(zhì)合成抑制、蛻皮激動、飛行調(diào)控、海藻糖酶抑制,拒食,尼古丁受體激動,殺蟲劑,除草劑,殺菌劑。

    新雜環(huán)化合物:氟化合物,氟烷氧基化合物,芳香雜環(huán),硫化合物,惡二唑、噻二唑、噠嗪酮、新煙堿、環(huán)亞胺、二芳;

    研究方向3. 化學(xué)生物技術(shù)與工程

    其研究主要體現(xiàn)在人工核酸酶,細(xì)胞激活劑和生物轉(zhuǎn)化,包括以下方面:

    人工核酸酶:由萘酰亞胺、硫雜環(huán)衍生的人工光核酸酶,光降解,人工核酸水解酶,DNA切斷劑,生物制備過程中轉(zhuǎn)基因物質(zhì)的去除。

    細(xì)胞激活劑:由茉莉酮酸酯、苯并噻二唑等衍生的細(xì)胞激活劑,用于人參、紫杉烷、靈芝的次生代謝物的增產(chǎn)與調(diào)控。

    生物轉(zhuǎn)化:酵母,植物細(xì)胞,立體選擇性還原,化學(xué)選擇性還原,芴,芳香硝基、胺、羥胺、酮還原、手性醇。

    研究成果

    上地幔變形作用和地球化學(xué)性質(zhì)之間的關(guān)系及其深部動力學(xué)意義。運(yùn)用綜合研究方法,探討了伊通新生代玄武巖中特有的具糜棱結(jié)構(gòu)的橄欖巖包體所經(jīng)歷的構(gòu)造熱演化及動力學(xué),證實了上地幔韌性剪切帶的存在。強(qiáng)調(diào)其形成與超大斷裂活動性之間的關(guān)系;并首次發(fā)現(xiàn)了橄欖巖包體中礦物顆粒間的氧同位素不平衡現(xiàn)象,為地幔剪切變形和地幔交代作用提供了時間約束,認(rèn)為流體的存在并不是剪切變形的先決條件,從而為地幔學(xué)術(shù)界長期爭論的流體和地幔變形之間的因果關(guān)系提供了新的判別依據(jù)。根據(jù)吉林汪清尖晶石相橄欖巖包體結(jié)構(gòu)、平衡溫度、主元素虧損程度和不相容元素富集程度之間的相關(guān)關(guān)系,提出了上地幔底辟上升和熱擴(kuò)散平衡的動力學(xué)模式,闡明了不同結(jié)構(gòu)類型包體在底辟體中的空間展布及其對交代流體遷移的控制。認(rèn)為所有研究樣品均來自巖石圈地幔,但由于下伏軟流圈的上涌而導(dǎo)致其流變學(xué)性質(zhì)的改變,從而同軟流圈一起發(fā)生底辟。這一成果為華北自中生代以來發(fā)生的大規(guī)模熱侵蝕-減薄機(jī)制提供了一個可行的動力學(xué)模式。

    上地幔熔體-巖石反應(yīng)機(jī)理及其微量元素理論模擬通過對伊通含富鉀硅酸鹽玻璃體的異剝橄欖巖和法國中央高原具鑲嵌結(jié)構(gòu)I型尖晶石相方輝橄欖巖包體的研究,橄欖巖包體的研究,鑒定出了單斜輝石生成反應(yīng)和橄欖石生成反應(yīng)兩個系列。這是對構(gòu)造橄欖巖體研究的重要補(bǔ)充,對地幔不均一性及巖漿源區(qū)混合作用的研究具有重要意義。后者還提供了巖石圈最底部-地幔熱柱相互作用的證據(jù)。運(yùn)用0-維數(shù)值模型計算了微量元素在上地幔熔體遷移/反應(yīng)過程中地球化學(xué)行為。該成果對認(rèn)識熔體/流體在深部巖石圈地幔演化過程中的作用具有重要意義。

    地幔地質(zhì)溫壓計的檢測,應(yīng)用和中國東部地幔巖石圈熱演化系統(tǒng)總結(jié)和科學(xué)評價了常用的二十多種溫度計和五種壓力計的優(yōu)缺點,為國內(nèi)學(xué)者更加審慎地選用溫壓計提供了依據(jù),在此基礎(chǔ)上,探討了中國東部上地幔熱結(jié)構(gòu)和熱演化歷史。以在特定熱演化階段中古老巖石圈/軟流圈相互作用程度為思路,結(jié)合實驗巖石學(xué)資料和巖石圈拉張歷史,提出了一個熱-構(gòu)造演化模式,從而比較合理地解釋了中國東部中生代末期-新生代玄武巖的巖性,微量元素和同位素地球化學(xué)演化特征,為深部地幔研究提供了新思路。

    中國東部幔源橄欖巖的鉑族元素地球化學(xué)研究在國內(nèi)率先開展了中國東部幔源橄欖巖的PGE地球化學(xué)研究,填補(bǔ)了中國在地幔巖PGE研究領(lǐng)域的空白。初步了解了不同類型巖石中這些元素的豐度和分布規(guī)律,揭示了中國東部上地幔特有的PGE分配型式(即富集Pt,虧損Ir和Pd)。探討了PGE在多種重要上地幔過程中的地球化學(xué)行為。

    榮譽(yù)成就

    1992?霍英東基金會高校優(yōu)秀青年教師獎(科研類);

    1995 全國優(yōu)秀教師;

    1996?國務(wù)院政府特殊津貼;

    1997 入選國家百千萬人才工程(第一、二層次);

    1998 中國青年科技獎;

    1999 第六屆上海十大科技精英;

    1994 國家教委科技進(jìn)步一等獎(第二完成人);

    1998 上海市科技進(jìn)步三等獎(第一完成人);

    1998 國家教育部科技進(jìn)步一等獎(第一完成人);

    2002 國家教育部科技進(jìn)步一等獎(第一完成人);

    2003 國家教育部自然科學(xué)一等獎(第一完成人)。

    2000 國家杰出青年科學(xué)基金獲得者;

    2001 大連市優(yōu)秀專家;

    2001-?中國化工學(xué)會農(nóng)藥委員會副主任委員。J. Fluorine Chemistry,Pesticide Biochemistry and Physiology等編委,在ChemCommun.,Org.Lett.,JACS等?SCI?國際學(xué)報發(fā)表論文近百十篇。專利十?dāng)?shù)項。此外,

    2003 擔(dān)任國家重點基礎(chǔ)研究發(fā)展規(guī)劃(973計劃) 項目首席科學(xué)家;

    2003-?國務(wù)院學(xué)位委員會學(xué)科評議組成員;

    2004-?國家自然科學(xué)基金委員會第十屆有機(jī)化學(xué)評議組成員,第十一屆化工評議組成員。

    2007. 3- 亞洲及太平洋化工聯(lián)盟主席。

    2011 中國工程院院士。

    學(xué)術(shù)論文

    研究方向1.染料的化學(xué)生物學(xué)

    ORG. LETT.-2006-3721: A series of polyamide receptor based PET fluorescent sensor molecules: Positively cooperative Hg2+ ion binding with high sensitivity

    ORG. LETT. 2005-3029: Colorimetric and ratiometric fluorescent chemosensor with a large red-shift in emission: Cu(Ⅱ)-only sensing by deprotonation of secondary amines as receptor conjugated to naphthalimide fluorophore

    ORG. LETT.-2005-889: Ratiometric and selective fluorescent sensor for Cu-Ⅱ based on internal charge transfer (ICT)

    ORG. LETT. 2004-2757: Novel fluorescent pH sensors based on intramolecular hydrogen bonding ability of naphthalimide (SS)

    J. ORG. CHEM.-2006-4308: Detecting Hg2+ ions with an ICT fluorescent sensor molecule: Remarkable emission spectra shift and unique selectivity

    J. ORG. CHEM.-2007-3554: Ratiometric and highly selective fluorescent sensor for cadmium under physiological pH range: A new strategy to discriminate cadmium from zinc

    CHEM. COMMUN.-2006-109: Two regioisomeric and exclusively selective Hg(Ⅱ) sensor molecules composed of a naphthalimide fluorophore and an o-phenylenediamine derived triamide receptor

    CHEM. COMMUN.-2005-239: A new class of long-wavelength fluorophores: strong red fluorescence,convenient synthesis and easy derivation

    CHEM. COMMUN.-2001-2656: Intramolecular aromatic 1,5-hydrogen transfer in preparation of oxacyclic naphthalic anhydride via unusual Pschorr cyclisation

    NEW J. CHEM.-2003-337: A polyamidoamine dendrimer with peripheral 1,8-naphthalimide groups capable of acting as a PET fluorescent sensor for metal cations

    NEW J. CHEM.-2002-920: Novel heterogeneous PET fluorescent sensors selective for transition metal ions or protons: polymers regularly labelled with naphthalimide

    J. AM. CHEM. SOC.-2004-2272: A highly selective and sensitive fluorescent chemosensor for Hg2+ in neutral buffer aqueous solution

    KIDNEY INTERNATIONAL-2004-2279: Fluorescent imaging of acute mercuric chloride exposure on cultured human kidney tubular epithelial cells

    CHEM. RES. TOⅪC.-2005-1814: Visible study of mercuric ion and its conjugate in living cells of mammals and plants

    CHEMBIOCHEM-2007-113: Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents (SS)

    J. MATER. CHEM. -2005-2836: A pH-resistant Zn(Ⅱ) sensor derived from 4-aminonaphthalimide: design,synthesis and intracellular applications

    MOL. CANCER THER.-2007-484: R16,a novel amonafide analogue,induces apoptosis and G2-M arrest via poisoning topoisomerase Ⅱ (SS)

    BIOORG. MED. CHEM. LETT.-2006-1562: Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor

    BIOORG. MED. CHEM. LETT.-2005-5909: Novel synthetic isoquinolino[5,4-ab]phenazines: Inhibition toward topoisomerase I,antitumor and DNA photo-cleaving activities

    BIOORG. MED. CHEM. LETT.-2005-4864: Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation,side chains,and substituent groups (SS)

    BIOORG. MED. CHEM. LETT.-2005-4864: Synthesis,antitumor evaluation and DNA photocleaving activity of novel methylthiazonaphthalimides with aminoalkyl side chains (SS)

    BIOORG. MED. CHEM. LETT.-2005-1139: Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA (SS)

    BIOORG. MED. CHEM. LETT.-2003-5427: Novel naphthalimide hydroperoxide photonucleases: The role of thiocyclic-fused area and the difference in spectra,photochemistry and photobiological activity (SS)

    BIOORG. MED. CHEM.-2007-1356: Novel antitumor agent family of 1H-benzo[c,d]indol-2-one with flexible basic side chains: Synthesis and biological evaluation (SS)

    BIOORG. MED. CHEM.-2006-6962:Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: Various DNA binding geometry and interesting antitumor capacity (SS)

    BIOORG. MED. CHEM.-2006-4639: Design,synthesis,and antitumor evaluation of novel acenaphtho[1,2-b]pyrrole-carboxylic acid esters with amino chain substitution (SS)

    BIOORG. MED. CHEM. -2005-3149: Novel heterocyclic family of phenyl naphthothiazole carboxamides derived from naphthalimides: synthesis,antitumor evaluation,and DNA photocleavage (SS)

    BIOORG. MED. CHEM.-2005-1615: Thio-heterocylic naphthalimides with aminoalkyl side chains: novel alternative tools for photodegradation of genomic DNA without impairment on bioactivities of proteins (SS)

    TETRAHEDRON LETT.-2005-6289: A proton sponge-based fluorescent switch

    TETRAHEDRON LETT.-2004-3969: A novel chromatism switcher with double receptors selectively for Ag+ in neutral aqueous solution: 4,5-diaminoalkeneamino-N-alkyl-1,8-naphthalimides

    TETRAHEDRON LETT.-2003-2087: Novel highly efficient fluoroionophores with a peri-effect and strong electron-donating receptors: TICT-promoted PET and signaling response to transition metal cations with low background emission

    TETRAHEDRON LETT.-2003-795: Promoting effects of the hydroxymethyl group on the fluorescent signaling recognition of anions by thioureas

    TETRAHEDRON LETT.-2002-2991: 4-Amino-1,8-dicyanonaphthalene derivatives as novel fluorophore and fluorescence switches: efficient synthesis and fluorescence enhancement induced by transition metal ions and protons

    TETRAHEDRON LETT.-2002-2995: Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: an efficient &apos;time-resolved&apos; DNA photocleaver with long-wavelength (SS)

    TETRAHEDRON LETT.-2001-6175: N-aroyloxynaphthalimides as novel highly efficient DNA photocleavers: substituent effects

    TETRAHEDRON LETT.-2000-7711: Novel and highly efficient DNA photocleavers: hydroperoxides of heterocyclic-fused naphthalimides

    TETRAHEDRON-2005-11895: Novel DNA bis-intercalators of isoquinolino[4,5-bc]acridines: design,synthesis and evaluation of cytotoxic activity

    TETRAHEDRON-2005-8717: Synthesis,antitumor and DNA photocleaving activities of novel naphthalene carboxamides: effects of different thio-heterocyclic rings and aminoalkyl side chains (SS)

    TETRAHEDRON-2005-6634: Synthesis of thiazo- or thiadiazo- naphthalene carboxamides via mercuric intermediates and their antitumor and DNA photocleavage activities (SS)

    TETRAHEDRON-2006-10117: Exploiting the deprotonation mechanism for the design of ratiometric and colorimetric Zn2+ fluorescent chemosensor with a large red-shift in emission

    DYES PIGMENTS-2002-247: Synthesis and properties of oligonucleotides containing fluorescent ethenodeoxyadeno sine and ethenodeoxycytidine

    DYES PIGMENTS-2001-51: Absorption and fluorescence spectral properties of tetra (fluoroalkoxy) metallophthalocyanines (FF)

    DYES PIGMENTS-2001-43: Oxazolonaphthalimides and their hydroperoxides: photophysical and photobiological properties

    DYES PIGMENTS-2004-9: Benzothioxanthene dyes as fluorescent label for DNA hybridization: synthesis and application (SS)

    DYES PIGMENTS-2004-17: Synthesis and peroxidase-staining properties of novel water soluble polyhydroxylalkyl benzidine dyes

    J. FLUORINE CHEM.-2002-161: Synthesis and photosensitizing properties of fluoroalkoxyl phthalocyanine metal complexes (FF)

    J. FLUORINE CHEM.-2000-69: Synthesis of fluorine-containing oxazolonaphthalimide hydroperoxides as DNA photocleavers (FF)

    CHINESE J. ORG. CHEM.1997-329: Synthesis and characterizations of the dye sensitized photooxygenation products and the heterocycles of naphthofuran derivatives

    CHINESE J. ORG. CHEM.-1997-428: Synthesis,characterization and DNA intercalation of a furonaphthopyronone as a novel analogue of furocoumarin

    CHINESE J. ORG. CHEM.-2000-338: Synthesis and structure characterization of two thienonaphthopyrones (SS)

    CHINESE J. ORG. CHEM. 2006-504: Synthesis and properties of N-butyl-4-(aza-15-crown-5)-1,8-naphthalimide as a fluorescent probe

    CHEM. RESEARCH IN CHINESE UNⅣ.-2005-480: A novel photocleaver with long wavelength absorption - Highly efficient antitumor agent: 4-(2-diethylamino -ethylamino)-8-oxo-8H-acenaphtho-[ 1,2-b] pyrrole-9-carbonitrile

    CHEM. J. CHINESE UNⅣ.-1996-1399: Syntheses,DNA Intercalation Activities and Molecular Modelling on Structures of Tatramethyldifuronaphthalenes

    J. PHOTOCHEM. PHOTOBIO. B-2001-35: Tetra-trifluoroethoxyl zinc phthalocyanine: potential photosensitizer for use in the photodynamic therapy of cancer (SS)

    J. PHOTOCHEM. PHOTOBIO. B-2006-221: Isoquino[4,5-bc]acridines: Design,synthesis and evaluation of DNA binding,anti-tumor and DNA photo-damaging ability

    J. CHEM. SOC.-PERKIN TRANSACTIONS 2-2000-715: Interaction of naphthyl heterocycles with DNA: effects of thiono and thio groups (SS)

    MONATSH CHEM.-1999-1109: Synthesis of novel DNA-intercalating naphthopyrone derivatives with improved water solubility and photophysical properties

    BULL. CHEM. SOC. JAPAN-1999-1571: Highly efficient photoinduced DNA cleavage by naphthopyrone hydroperoxides

    CHEM. LETT.-2005-696: Novel naphthalimide fluorescent sensors selective for certain proteins on basis of non-covalent interactions between enzyme and inhibitor (SS)

    SYNTHESIS-STUTTGART-1999-1109: General synthesis of thioxo-1,8-naphthalimides via thioxo-1,8-naphthalic anhydrides (SS)

    HETEROATOM CHEM.-1999-141: The improved synthesis,Diels-Alder reactions,and desulfuration of trithio-1,8-naphthalic anhydride (SS)

    POLYMER-2002-5731: Synthesis and photophysical properties of 1,8-naphthalimide-labelled PAMAM as PET sensors of protons and of transition metal ions

    CHINESE J. ANAL. CHEM. -2004-837: Studies on the room temperature phosphorescence of halogen naphthalic anhydrides

    CHINESE CHEM. LETT.-2004-118: Anthracylmethyl benzoazacrown ether as selective fluorescence sensors for Zn2+

    HETEROCYCL. COMMUN.-2003-229: A new class of DNA intercalator and photocleaver: Bis-naphthailimides with bromo and nitro substituents

    MONATSH. CHEM.-2003-393: New fluorescent conjugates of uridine nucleoside and substituted 1,8-naphthalimide: Synthesis,weak interactions and solvent effects on spectra

    INT. J. BIO. MACROMOL.-2006-59: Study on the interaction between 4-(2-diethylanuno- ethylamino)-8-oxo-8H- acenaphtho[1,2-b]pyrrole-9-carbonitrile and DNA by molecular spectra

    研究方向2.農(nóng)藥的化學(xué)與生物學(xué)

    J. AGRI. FOOD CHEM.-2007-2288: Synthesis,insecticidal activity,and QSAR of novel nitromethylene neonicotinoids with tetrahydropyridine fixed cis configuration and exo-ring ether modification

    J. AGRI. FOOD CHEM.-2006-125: Synthesis and herbicidal activity of novel 3-aminocarbonyl-2-oxazolidinethione derivatives containing a substituted pyridine ring

    J. AGRI. FOOD CHEM.-2006-8793: Novel,unnatural benzo-1,2,3-thiadiazole-7-carboxylate elicitors of taxoid biosynthesis (SS,FF)

    J. AGRI. FOOD CHEM.-2005-3120: Syntheses,antifeedant activity,and QSAR analysis of new oxa(thia)diazolyl 3(2H)-pyridazinones (SS)

    J. AGRI. FOOD CHEM.-2005-3120: Syntheses,Antifeedant Activity,and QSAR Analysis of New Oxa(thia)diazolyl 3(2 H)-Pyridazinones (SS)

    J. AGRI. FOOD CHEM.-2003-152: Synthesis and Antifeedant Activity of New Oxadiazolyl 3(2H)-Pyridazinones

    J. AGRI. FOOD CHEM.-2001-124: Synthesis and Quantitative Structure-Activity Relationships of New 2,5-Disubstituted-1,3,4-oxadiazoles (FF)

    J. AGRI. FOOD CHEM.-2001-5279: Synthesis and Quantitative Structure-Activity Relationships of Fluorine-Containing 4,4-Dihydroxylmethyl-2-aryl imino- oxazo (thiazo)lidines as Trehalase Inhibitors (SS,FF)

    J. AGRI. FOOD CHEM.-1999-4415: Quantitative studies on structure-activity relationship of sulfonylurea and benzoylphenylurea type pesticides and their substituents&apos; bioisosterism using synthons&apos; activity contribution (SS,FF)

    J. AGRI. FOOD CHEM.-1996-1538: Molecular modeling study on the structure-activity relationship of substituted dibenzoyl-1-tert-butylhydrazines and their structural similarity to 20-hydroxyecdysone

    ACS SYMPOSIUM SERIES-2005(892)-273: Oxadiazole derivatives as novel insect-growth regulators: Synthesis and structure-bioactivity relationship (FF)

    J. FLUORINE CHEM.-2006-182: Synthesis and herbicidal activities of fluorine-containing 3-pyridylmethyl-2- phenyliminothiazolidine derivatives (SS,FF)

    J. FLUORINE CHEM.-2005-297: Synthesis and fungicidal activity of fluorine-containing phenylimino-thiazolidines derivatives (SS,FF)

    J. FLUORINE CHEM.-2005-53: Synthesis and biological activities of hydroxyl-protected fluorine-containing 4,4-dihydroxylmethyl-2-aryl-iminothiazolidines (SS,FF)

    J. FLUORINE CHEM.-2004-1159: Synthesis and fungicidal activity of Fluorine-containing Phenylimino-thiazolidines Derivatives (SS,FF)

    J. FLUORINE CHEM.-2004-1609: Syntheses,structures and bioactivities of fluorine-containing phenylimino-thia(oxa)zolidine derivatives as agricultural bioregulators (SS,FF)

    J. FLUORINE CHEM.-2003-163: Synthesis and insecticidal activities of novel 2,5-disubstituted 1,3,4-oxadiazoles (FF)

    J. FLUORINE CHEM.-2003-51: Synthesis and insecticidal activity of new substituted N-aryl-Nu2019-benzoylthiourea compounds (SS,FF)

    J. FLUORINE CHEM.-2002-63: Syntheses and insecticidal activity of new 2-(5-(trifluoromethyl)pyridyloxymethyl) -1,3,4-oxadiazoles] (FF)

    J. FLUORINE CHEM.-2000-111: Fluorine containing heterocyclic compounds: synthesis of 6-substituted-2-substituted-aryl-1,2,4-triazolo[5,1-b] 1,3,5- thia- diazin-7-one derivatives (SS,FF)

    J. FLUORINE CHEM.-2000-173: Syntheses and insecticidal activities of novel 2-fluorophenyl-5-aryl/cyclopropyl-1,3,4-oxadiazoles (FF)

    J. FLUORINE CHEM.-2001-143: Synthesis and biological activities of fluorine-containing N,Nu2019-diphenylcarbamimidothioates (SS,FF)

    J. FLUORINE CHEM.-1999-39: Syntheses and characterization of 2-amino-5-aryl-1,3,4-oxadiazoles containing trifluoroethoxy groups (FF)

    J. FLUORINE CHEM.-1998-9: Polyfluoroalkoxylation and methoxylation of polychloropyridines (FF)

    J. FLUORINE CHEM.-1996-9: Alcoholysis of trifluoromethyl groups attached to the pyridine ring (FF)

    J. FLUORINE CHEM.-1991-143: A synthetic and MO-SCF study of the trifluoroethoxylation of chloro(trifluoromethyl)pyridine derivatives (FF)

    CHEM. PHYS. LETT.-2003-489: Intramolecular noncovalent force in cyclic amidines: nonbonded interaction between carbon atoms and heteroatoms (SS,FF)

    PEST. MANAG. SCI. -2003-933: The toxic and anti-feedant activity of 2H-pyridazin-3-one-substituted 1,3,4-oxadiazoles against the armyworm Pseudaletia separata (Walker) and other insects and mite

    CARBOHYDRATE RESEARCH-2001-79: Syntheses and activities as trehalase inhibitors of N-arylglycosylamines derived from fluorinated anilines (FF)

    J. CHEM. TECH. BIOTECH.-1996-124: Syntheses and insecticidal activities of novel 2,5-disubstituted-1,3,4-oxadiazoles (FF)

    CAN. J. CHEM. -2003-272: N&apos;-tert-Butyl-N&apos;-aroyl-N-(alkoxycarbonylmethyl)-N-aroylhydrazines,a novel nonsteroidal ecdysone agonist: syntheses,insecticidal activity,conformational and crystal structure analysis

    MONATSH CHEM.-2006-779: An efficient and practical method for the synthesis of 1-(2,6-difluorobenzoyl)-3-(2-alkyl-3-oxopyridazin-4-yl)ureas as potential chitin synthesis inhibitors (FF)

    MONATSH CHEM.-2000-953: Novel fused heterocycles: Synthesis and activity of 5,6-dihydro-7-thia-1,3,3a,5-tetraazainden-4-one and 1-thia-3,4a,9-triazafluoren-4-one derivatives (SS)

    J. CHEM. RES.-2006- 626: Synthesis and bioactivities of novel neonicotinoids dioxolane compounds

    J. CHEM. RES.-2000-88: The crystal structure of 1-phenyl-3-methyl-5-[2 &apos;-(4 &apos;&apos;-phenylmethoxylphenyl)ethoxyl]pyrazole,a potential insect juvenile hormone mimic

    J. CHEM. RES.-1999-66: The crystal structure of N-(5-phenyl-1,3,4-oxadiazol-2-yl)-N &apos;-benzoyl urea,a novel insect-growth regulator

    J. CHEM. RES. -1998-478: Crystal structure of 1-(3,5-dichloro-2,4-difluorophenyl)-3-(2,6-difluorobenzoyl)urea,an inhibitor of chitin synthesis (SS,FF)

    CHEM. J. CHINESE UNⅣ.-1994-224: Synthesis and bioactivities of novel trifluoromethylpyridine derivatives

    CHINESE CHEM. LETT. -2004-7: Novel Analogues of -Terthienyl,Thienyl 1,3,4-Thia(oxa)diazoles as Potential Photoactivated Insecticides:Synthesis and Bioactivity (SS)

    PESTICIDE BIOCHEM. PHYSIOLOGY-2004-42: Photolarvicidal effect of thienyl 1,3,4-thia(oxa)diazoles and their potential DNA photocleavage (SS)

    ARKⅣOC-2003-141: Synthesis and insecticidal activity of 1,2,4-triazole derivatives

    CHEM. LETT.-2001-54: A Novel and Practical Amination of 4,5-Dichloropyridazin-3-ones via Reduction with Hydrazine Hydrate

    ORG. PREP. PROCEDURE INTL.-2000-571: A facile synthesis of aryl isothiocyanates from arylamines (SS)

    ORG. PREP. PROCEDURE INTL.-1999-110: A facile synthesis of 3-chloro-4-(2 &apos;,2 &apos;,2 &apos;-trifluoroethoxy)benzonitrile (FF)

    研究方向3.化學(xué)生物技術(shù)與工程

    CHEM. COMMUN.-2006-865: Baker&apos;s yeast-mediated enantioselective reduction of substituted fluorenones (FF)

    CHEM. COMMUN.-2005-2338: A novel strategy for the preparation of arylhydroxylamines: chemoselective reduction of aromatic nitro compounds using bakers&apos; yeast

    CHEM. COMMUN.-2004-2339: A novel strategy for the preparation of arylhydroxylamines: chemoselective reduction of aromatic nitro compounds using bakersu2019 yeast

    APPL. MICROBIO. BIOT.-2005-98: A novel synthetic fluoro-containing jasmonate derivative acts as a chemical inducing signal for plant secondary metabolism (FF)

    APPL. MICROBIOL. BIOT.-2006-164: Novel synthetic 2,6-dichloroisonicotinate derivatives as effective elicitors for inducing the biosynthesis of plant secondary metabolites

    APPLIED MICROBIO.BIOTECH.-2006-298: Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate

    BIOORG. MED. CHEM. LETT.-2005-1769: Novel 2-aminothiazonaphthalimides as visible light activatable photonucleases: effects of intercalation,heterocyclic-fused area and side chains (SS)

    BIOORG. MED. CHEM. LETT.-2003-3513: Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms (SS,FF)

    BIOORG. MED. CHEM. LETT.-2004-2665: Highly-efficient DNA photocleavers with long wavelength absorptions: thio-heterocyclic fused naphthalimides containing aminoalkyl side chains (SS)

    BIOORG. MED. CHEM. LETT.-2004-2335: N-aroyloxylthioxo-naphthalimides as DNA photocleavers of aroyloxyl oxygen radicals: synthesis,evaluation,and substituents&apos; effect (SS)

    BIOORG. MED. CHEM. LETT.-2004-4755: Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis (FF)

    BIOORG. MED. CHEM. LETT.-2006-803: Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease (SS)

    BIOORG. MED. CHEM.-2006-2935: Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding

    BIOORG. MED. CHEM.-2006-23: Eliminating nucleic acids contaminants by hydrogen peroxide-induced free radicals during the preparation of proteins (SS)

    BIOTECH. BIOENG-2005-516: Highly efficient strategy for enhancing taxoid production by repeated elicitation with a newly synthesized jasmonate in fed- batch cultivation of Taxus chinensis cells

    BIOTECH. BIOENG.-2004-809: Novel chemically synthesized hydroxyl-containing jasmonates as powerful inducing signals for plant secondary metabolism

    BIOTECH. BIOENG.-2004-595: Novel synthetic jasmonates as highly efficient elicitors for taxoid production by suspension cultures of Taxus chinensis

    BIOTECH. PROGR.-2006-331: Novel chemically synthesized salicylate derivative as an effective elicitor for inducing the biosynthesis of plant secondary metabolites

    BIOTECH. AND BIOPROCESS ENGI.-2005-162: Efficient elicitation of ginsenoside biosynthesis in cell cultures of Panax notoginseng by using self-chemically-synthesized jasmonates

    BIOCHEM. ENGINEERING. J.-2006-23: Eliminating nucleic acids contaminants by hydrogen peroxide-induced free radicals during the preparation of proteins

    TETRAHEDRON LETT.-2004-1247: Naphthalimide-thiazoles as novel photonucleases: molecular design,synthesis,and evaluation (SS)

    TETRAHEDRON-2005-11264: Versatile acenaphtho[1,2-b]pyrrol-carbonitriles as a new family of heterocycles: diverse Snar(H)H reactions,cytotoxicity and spectral behavior (SS)

    DYES AND PIGMENTS-1999-139: Naphthalimide hydroperoxides as photonucleases: substituent effects and structural basis.

    主要兼職

    Journal of Fluorine Chemistry 國際編委

    Pesticide Physiology and Biochemistry 國際編委

    中國化工學(xué)會 副理事長

    德國洪堡基金會(A.v.H/ Ambassador Scientist) 大使科學(xué)家

    英國皇家化學(xué)會(Royal Society of Chemistry) 會士 (Fellow)

    亞洲及太平洋化工聯(lián)盟 (APCChE) 主席 (President)

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