專家信息
谷立川（1974.2-）男，河北省贊皇縣人。漢族，山東大學(xué)微生物技術(shù)國家重點實驗室教授，博士生導(dǎo)師。
教育經(jīng)歷
1998 年 9 月 -2002 年 1 月 博士研究生，中科院生物物理研究所。
1995 年 9 月 -1998 年 7 月 碩士研究生，山東大學(xué)化學(xué)與化工學(xué)院。
1991 年 9 月 -1995 年 7 月 本科生，山東大學(xué)物理系。
工作經(jīng)歷
2006 年 6 月 - 至今 教授，山東大學(xué)微生物技術(shù)國家重點實驗室。
2002 年 8 月 -2006 年 6 月 博士后研究人員，普林斯頓大學(xué)分子生物學(xué)系。
2002 年 1 月 -2002 年 8 月 研究人員，中科院生物物理研究所。
科學(xué)研究：
研究方向
1. 致病微生物蛋白質(zhì)的結(jié)構(gòu)與功能。
2. 重要微生物代謝途徑相關(guān)酶的結(jié)構(gòu)與功能研究；
3. 基于蛋白質(zhì)結(jié)構(gòu)的藥物設(shè)計。
承擔(dān)課題情況：
863重大項目,2006AA02A324，重要致病微生物蛋白質(zhì)的結(jié)構(gòu)研究，490萬元。
教學(xué)情況：
講授課程：
結(jié)構(gòu)生物學(xué)
人才培養(yǎng)情況：
目前在讀博士生2人，碩士生4人。
招生情況：
2009年博士招生計劃：博士生2人。畢業(yè)后適合于從事生物學(xué)的基礎(chǔ)研究，或者國際著名制藥公司從事藥物開發(fā)工作。
PROFESSIONAL EXPERIENCE
Jun 2006 - present Professor in State Key Laboratory of Microbial Technology, Shandong University. Jinan 250100, P. R. China. Aug 2002 - Jun 2006 Postdoctoral fellow in Department of Molecular Biology at Princeton University, Princeton, NJ08544, USA Jan 2002 u2013 Aug 2002 Research associate in Institute of Biophysics, Chinese Academy of Science, Beijing 100101, P. R. China.
EDUCATION
Sep 1998 - Jan 2002 PhD. Biochemistry and Molecular Biology, Chinese Academy of Science, Beijing 100101, P. R. China. Sep 1995 - Jul 1998 M.S. Physical Chemistry, School of Chemisty and Chemichal Engineering, Shandong University, Jinan 250100, P. R. China. Sep 1991 u2013 Jul 1995 B.S. Physics, Department of Physiscs Shandong University, Jinan 250100, P. R. China. RESEARCH
INTERESTS
The research in my laboratory is aimed at understanding the structural and molecular mechanisms involved in important cellular process, with focus on
· Key enzymes in the pollutants microbial degradation pathways;
· Key components in DNA repair system;
· Virulence factors of important pathogens. Our approaches encompass a variety of biochemical and biophysical methods, in which X-ray crystallography is the most important technique. PUBLICATIONS：
1. Min Hu, Lichuan Gu , Philip D. Jeffrey, and Yigong Shi. (2006). Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53/MDM2 Pathway. PloS Biology 4, e27
2. Nieng Yan, Jijie Chai, Eui Seung Lee, Lichuan Gu , Qun Liu, Jiaqing He, Jia-Wei Wu, David Kokel, Huilin Li, Quan Hao, Ding Xue, and Yigong Shi (2005). Structure of the CED-4/CED-9 complex reveals insights into programmed cell death in Caenorhabditis elegans . Nature 437, 831u2013837 .
· Liang Feng*, Suiping Zhou*, Lichuan Gu* , David A. Gell, Joel P. Mackay, Mitchell J. Weiss, Andrew J. Gow and Yigong Shi. Structure of oxidized -haemoglobin bound to AHSP reveals a protective mechanism for haem. Nature. 2005 Jun 2;435(7042):697-701. ( *These authors contributed equally ).
· Liang Feng*, David A*. Gell, Suiping Zhou*, Lichuan Gu , Yi Kong, Jianqing Li, Min Hu, Nieng Yan, Christopher Lee, Anne M. Rich, Robert S. Armstrong, Peter A. Lay, Andrew J. Gow, Mitchell J. Weiss, Joel P. Mackay, and Yigong Shi. Molecular Mechanism of AHSP-mediated Stabilization of alpha-hemoglobin. Cell. 2004 Nov 24;119(5):629-40. ( *These authors contributed equally ).
· Nieng Yan*, Lichuan Gu *, David Kokel*, Jijie Chai, Wenyu Li, Aidong Han, Lin Chen, Ding Xue, and Yigong Shi. Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4. Mol Cell. 2004 Sep 24;15(6):999-1006. ( *These authors contributed equally ).
· Eric N. Shiozaki, Lichuan Gu , Nieng Yan, and Yigong Shi. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Mol Cell. 2004 May 7;14(3):405-12.
· Sujuan Xu, Lichuan Gu , Qingyan Wang, Yuyan Shu, Shiying Song, Zhengjiong Lin. Structure of a king cobra phospholipase A2 determined from a hemihedrally twinned crystal.Acta Crystallogr D Biol Crystallogr. 2003 Sep;59(Pt 9):1574-81.
· Sujuan Xu, Lichuan Gu , Tao Jiang, Yuangcong Zhou, Zhengjiong Lin. Structures of cadmium-binding acidic phospholipase A(2) from the venom of Agkistrodon halys Pallas at 1.9A resolution. Biochem Biophys Res Commun. (2003) 300(2):271-7.
· Lichuan Gu , Zhiqing Wang, Shiying Song, Yuyan Shu, Zhengjiong Lin. Crystal structures of an acidic phospholipase A(2) from the venom of Naja Kaouthia. Toxicon. (2002) 40(7):917-22.
· Lichuan Gu , Hailong Zhang, Shiying Song, Yuancong Zhou, Zhengjiong Lin. Structure of an acidic phospholipase A2 from the venom of Deinagkistrodon acutus. Acta Crystallogr D Biol Crystallography. (2002) 58(Pt 1):104-10.
