劉明耀教授，男，1962年生于湖南，1982年獲湖南師范大學(xué)學(xué)士學(xué)位，1985年獲湖南師范大學(xué)碩士學(xué)位，1992年獲美國馬里蘭大學(xué)細胞生物學(xué)博士學(xué)位；1993年到1998年先后在美國約翰-霍普金斯大學(xué)醫(yī)學(xué)院神經(jīng)科學(xué)系和加州理工學(xué)院生物學(xué)部做博士后研究；1999至2007年先后在美國德克薩斯農(nóng)工大學(xué)生物科學(xué)與技術(shù)研究所任助理教授、副教授及終身教授。

2007年受聘回國加入華東師范大學(xué)，組建生命醫(yī)學(xué)研究所并任所長；2011年12月起擔(dān)任上海市調(diào)控生物學(xué)重點實驗室主任，同年起擔(dān)任教育部創(chuàng)新團隊帶頭人、國家重大科學(xué)研究計劃（973項目）首席科學(xué)家；2012年入選上海市優(yōu)秀學(xué)科帶頭人，2012年起任華東師范大學(xué)生命科學(xué)學(xué)院院長。

劉明耀教授致力于G蛋白偶聯(lián)受體（GPCR）在個體發(fā)育和腫瘤及重大疾病發(fā)生發(fā)展過程中的功能及信號轉(zhuǎn)導(dǎo)機理研究，以及靶向GPCR的新藥研發(fā)�；貒�后作為首席科學(xué)家主持中國重大科學(xué)研究計劃1項，主持國家自然科學(xué)基金重點項目2項，參與國家重大專項新藥創(chuàng)制項目1項。已在Science、Nature、Nature Biotechnology、PNAS、J Natl Cancer Inst等國際學(xué)術(shù)刊物上發(fā)表SCI論文150多篇，申請專利30多項，獲得授權(quán)專利6項。

主持多項美國國立衛(wèi)生研究院（NIH）研究項目

主持多項美國國防部（DOD）研究項目

主持中國科委973前期項目一項

主持上海市科委"細胞信號轉(zhuǎn)導(dǎo)網(wǎng)絡(luò)研究技術(shù)"研發(fā)公共服務(wù)平臺。

G-蛋白偶聯(lián)受體及其信號轉(zhuǎn)導(dǎo)途徑基因敲除和轉(zhuǎn)基因動物

細胞信號網(wǎng)絡(luò)與疾病

血管新生與分子藥理學(xué)

干細胞和發(fā)育生物學(xué)

生殖和代謝疾病

腫瘤生長與轉(zhuǎn)移的分子機理

劉明耀教授的研究領(lǐng)域主要涉及發(fā)育和疾病過程中G-蛋白偶聯(lián)受體(GPCRs)及其信號轉(zhuǎn)導(dǎo)途徑在胚胎發(fā)育和疾病發(fā)生過程中的作用（包括生殖系統(tǒng)、癌癥、糖尿病、骨骼和心血管系統(tǒng)）。G-蛋白偶聯(lián)受體是已知數(shù)目最多的細胞表面受體家族，它們把多種多樣的胞外信號傳遞到細胞內(nèi)，并通過和其它信號轉(zhuǎn)導(dǎo)途徑間的相互作用廣泛參與細胞增殖、分化、遷移，尤其是各類生理活動和疾病的調(diào)控。劉明耀教授實驗室研究的總體目標就是利用基因敲除和轉(zhuǎn)基因動物技術(shù)平臺研究構(gòu)建疾病模型并研究GPCRs在生物體中的功能；利用細胞信號轉(zhuǎn)導(dǎo)網(wǎng)絡(luò)技術(shù)平臺來闡明GPCRs在正常和疾病狀態(tài)下的細胞和分子機制。其最終目標是開發(fā)特異靶向性膜受體和信號途徑的疾病治療藥物。研究領(lǐng)域集中在G蛋白偶聯(lián)受體(GPCRs)及其信號轉(zhuǎn)導(dǎo)途徑，包括1）發(fā)育和代謝疾�。�2）腫瘤發(fā)生，發(fā)展和轉(zhuǎn)移的分子機理；3）血管新生和抗血管新生藥物的分子機制及新藥研發(fā)；4）炎癥和腫瘤免疫中G蛋白偶聯(lián)受體介導(dǎo)的NF-КB信號途徑；5）干細胞分化調(diào)控和人類疾病轉(zhuǎn)基因動物模型的建立。

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2005年發(fā)表的論文

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2006年發(fā)表的論文

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2007年發(fā)表的論文

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- Outstanding Graduate Student Research Award, University of Maryland, 1992

- National Institutes of Health (NIH) Fellowship, 1992

- HHMI Postdoctoral Fellowship, 1993-1994

- Scientist Development Award, American Heart Association National, 1999

- Basil Ou2019Connor Scholar Award from March of Dimes Foundation, 2001

- President, Society of Chinese Bioscientists in America, Texas Chapter, 2003-2004

代表性的論文(選自60多篇SCI 文章)