一、教育經(jīng)歷

1983年天津醫(yī)科大學(xué)本科畢業(yè)，1989年浙江大學(xué)醫(yī)學(xué)院，醫(yī)學(xué)碩士學(xué)位。1998年英國(guó)伯明翰大學(xué)醫(yī)學(xué)院，博士學(xué)位。

二、工作經(jīng)歷

1983年天津醫(yī)科大學(xué)本科畢業(yè)，1989年浙江大學(xué)醫(yī)學(xué)院獲醫(yī)學(xué)碩士學(xué)位。1998年英國(guó)伯明翰大學(xué)醫(yī)學(xué)院獲博士學(xué)位。2003起至今為南開大學(xué)教授。

三、學(xué)術(shù)兼職

天津市生物醫(yī)學(xué)檢測(cè)技術(shù)與儀器重點(diǎn)實(shí)驗(yàn)室學(xué)術(shù)委員會(huì)委員

天津市神經(jīng)損傷變異與再生重點(diǎn)實(shí)驗(yàn)室學(xué)術(shù)委員會(huì)委員

中華醫(yī)學(xué)研究雜志專家編輯委員會(huì)常務(wù)編委

中華臨床醫(yī)學(xué)雜志英文版編委

天津醫(yī)藥編委及英文編輯

1． 生理學(xué)
2． 專業(yè)英語(yǔ)
3． 若干研究生及碩士生課程

研究方向：

1圍繞神經(jīng)系統(tǒng)重大疾病，開發(fā)和制備了相關(guān)的動(dòng)物模型，并在動(dòng)物模型基礎(chǔ)上進(jìn)行神經(jīng)電生理、認(rèn)知、神經(jīng)細(xì)胞的免疫組化及突觸機(jī)制等研究。

2納米顆粒在中樞神經(jīng)系統(tǒng)的作用和毒性的機(jī)制。

3 腎發(fā)育有關(guān)的離子通道機(jī)制研究。

4海馬神經(jīng)通路的交互作用與神經(jīng)元突觸傳遞效率。

天津市應(yīng)用基礎(chǔ)與前沿技術(shù)研究計(jì)劃重點(diǎn)項(xiàng)目（10JCZDJC19100）

科技部973項(xiàng)目(2011CB944003)

國(guó)家自然科學(xué)基金項(xiàng)目(31070890)

英國(guó)皇家工程學(xué)院與中國(guó)研究交流項(xiàng)目Ref 5502）

1.Dehong Shan,Yongling Xie, Guogang Ren, Zhuo Yang. Inhibitory effect of tungsten carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neurons. Toxicology Letters. 2012; (209): 129-135
2. Jing Xu, Pengjuan Xu, Zhigui Li, Jie Huang, Zhuo Yang*. Oxidative stress and apoptosis induced by hydroxyapatite nanoparticles in C6 cells. J Biomed Mater Res A. 2012;100(3): 738-745
3. Liu Ye, Guan Wei, Ren G, Yang Zhuo. The possible mechanism of silver nanoparticle impact on hippocampal synaptic plasticity and spatial cognition in rats. Toxicol Lett. 2012;(209): 227-231
4. Yongling Xie, Yiyi Wang, Tao Zhang, Guogang Ren, Zhuo Yang,Effects of nanoparticle zinc oxide on spatial cognition and synaptic plasticity in mice with depressive-like behaviors. The Journal of Biomedical Science. 2012;19(1):14
5. XU Jing, WANG Yiyi, LI Ning, XU Lanju, YANG Hanyu, YANG Zhuo. l-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia. Neuropharmacology. 2012;62(7):2423u20132428
6. Liu Z, Zhang T, Ren G, Yang Z. Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons. Nanotoxicology. 2012;6:414-423
7. Xu Pengjuan, Xu Jing, Li Zhigui, Yang Zhuo. Expression of TRPC6 in renal cortex and hippocampus of mouse during postnatal development. PLoS One.2012;7(6):e38503（P1-P8）
8. Jing Xu, Zhigui Li, Pengjuan Xu and Zhuo Yang. Protective effects of leukemia inhibitory factor against oxidative stress during high glucose-induced apoptosis in podocytes. Cell Stress Chaperones. 2012 Jul;17(4):485-93
9. Pengjuan Xu, Jing Xu, Shichang Liu, Guogang Ren, Yang Zhuo. In vitro to xicity of nanosized copper particles in PC12 cells induced by oxidative stress. Journal of Nanoparticle Research. 2012;14(906):1-9
10. Lu Xiao, Zhanyong Li, Pengjuan Xu, Zhigui Li, Jing Xu, Zhuo Yang.The Expression of EPOR in renal cortex during postnatal development. PLoS One. July 2012; 7(7): e41993
11. Han YG, Xu J, Li ZG, Ren GG, Yang Z. In vitro toxicity of multi-walled carbon nanotubes in C6 rat glioma cells. Neurotoxicology. 2012;33( 5): 128-134
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15．Yang-guang HAN, Shi-chang LIU, Tao ZHANG, Zhuo YANG， Induction of apoptosis by melamine in differentiated PC12 cells. Cell Mol Neurobiol, 2011; 31:65u201371
16. Shichang Liu, Yangguang Han, Tao Zhang, Zhuo Yang, Protective effect of trifluoperazine on hydrogen peroxide-induced apoptosis in PC12 cells. Brain Research Bulletin, 2011;84:183u2013188
17. Xiaofan Yang, Yucheng Wang, Jia Luo, Shichang Liu and Zhuo Yang，Protective effects of YC-1 against glutamate induced PC12 cell apoptosis. Cell Mol Neurobiol. 2011;31(2):303-11
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21. Yi-Yi Wang, Ning Li，Jie Huang，Zhuo Yang, Tao Zhang. Effects of ionic products from silicon-substituted hydroxyapatite on the rat brain activity: Morris water maze studies and long term potentiation in hippocampal CA1. Materials Science & Engineering: C (Materials for Biological Applications).2011;31:1558u20131566
22. Liu Zhaowei, Ren Guogang, Zhang Tao, Yang Zhuo. The inhibitory effects of nano-Ag on voltage-gated potassium currents of hippocampal CA1 neurons, Environmental Toxicology, 2011;26(5):552-8
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24. Y. Yao, D.D. Han, T. Zhang, Z. Yang, Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage-dependent sodium channels in hippocampal CA1 pyramidal neurons, Phytotherapy Research,2010;24: 136u2013140
25. Shichang Liu, Lanju Xu, Tao Zhang, Guogang Ren, Zhuo Yang, Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells，Toxicology,2010;267:172u2013177
26. Yinguo ZHANG, Ning LI, Zhuo YANG，Perinatal food restriction impaired spatial learning and memory behaviour and decreased the density of nitric oxide synthase neurons in the hippocampus of adult male rat offspring，Toxicology Letters，2010；193：167-172
27. Mei-Na Quan, Yu-Tao Tian, Kun-Han Xu, Tao Zhang, Zhuo Yang. Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats, Neuroscience；2010;169:214u2013222
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29. ZHANG Yinguo, LI Ning,YANG Jiajia，ZHANG Tao，YANG Zhuo, Effects of maternal food restriction on physical growth and neurobehavior in newborn Wistar rats, Brain Research Bulletin; 2010：83: 1-8
30. Yinguo ZHANG, Jingxia ZHAO, Tao ZHANG , Zhuo YANG，In vitro assessment of the effect of methylene blue on voltage-gated sodium channels and action potentials in rat hippocampal CA1 pyramidal neurons, Neurotoxicology. 2010;31(6):724-9
31. ZHAO Jingxia, XU Lanju, ZHANG Tao, REN Guogang，YANG Zhuo，Influences of nanoparticle zinc oxide on acutely isolated rat hippocampal CA3 pyramidal neurons，Neurotoxicology,2009;30:220-230
32. Yang Z, Han D, Coote JH. Cardiac sympatho-excitatory action of PVN-spinal oxytocin neurones. Autonomic Neuroscience: Basic and Clinical, 2009; 147:80-85
33. Lan-ju XU, Jing-Xia ZHAO, Tao ZHANG, Guo-gang REN, Zhuo YANG, In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents, Environmental Toxicology, 2009; 24(3):211-217
34. Liu Zhaowei, Ren Guogang, Zhang Tao, Yang Zhuo.Action potential changes associated with the inhibitory effects on voltage-gated sodium current of hippocampal CA1 neurons by silver nanoparticles. Toxicology,2009;264:179-184
35. Zhangjie Su，Dadong Han, Bo Sun, Jiaheng Qiu, Ying Li, Mu Li, Tao Zhang, Zhuo Yang. Heat Stress Preconditioning Improves Cognitive Outcome following Diffuse Axonal Injury in Rats.Journal of Neurotrauma，2009, 26(10): 1695-1706