基本信息
姓 名: 滕兆乾
學(xué) 科: 干細(xì)胞與腦損傷修復(fù)研究組
通訊地址: 北京市海淀區(qū)北四環(huán)西路25-1號
中國科學(xué)院動物研究所干細(xì)胞與生殖生物學(xué)國家重點(diǎn)實(shí)驗(yàn)室
個(gè)人簡歷
2005年博士畢業(yè)于中國科學(xué)院動物研究所，2005至2013年先后在中國農(nóng)業(yè)大學(xué)、美國新墨西哥大學(xué)醫(yī)學(xué)院、路易斯安娜州立大學(xué)健康科學(xué)中心做博士后，主要從事神經(jīng)發(fā)生與腦損傷方面的研究。2014年起，在美國約翰霍普金斯大學(xué)醫(yī)學(xué)院做Research Associate。2015年入選中科院百人計(jì)劃。研究成果發(fā)表在 Cell、 Cell Stem Cell、Neuron、Stem Cells、 Cell Reports、 Journal of Neuroscience、Journal of Cerebral Blood Flow and Metabolism 等國際學(xué)術(shù)期刊上
研究領(lǐng)域
研究工作主要集中在腦損傷的發(fā)病機(jī)理、神經(jīng)發(fā)生的分子調(diào)控、以及干細(xì)胞在腦損傷修復(fù)中的應(yīng)用研究。研究組的主要研究方向包括：（1）腦損傷后，大腦內(nèi)環(huán)境變化對神經(jīng)發(fā)生與神經(jīng)再生影響的分子機(jī)理；（2）慢性創(chuàng)傷性腦病的分子致病機(jī)制；（3）探索通過干細(xì)胞移植和改善神經(jīng)再生與可塑性內(nèi)環(huán)境而實(shí)現(xiàn)腦損科研項(xiàng)目
1. 2015-2017 中國科學(xué)院“百人計(jì)劃”，主持，在研
2. 2016-2019 國家自然科學(xué)基金面上項(xiàng)目，主持，在研
代表論著
Jian Zhang, Zhao-Qian Teng, Yunping Song, Mei Hu, Chu Chen. Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury. J Cereb Blood Flow Metab
Jian Zhang, Mei Hu, Zhao-Qian Teng, Yunping Song, Chu Chen. Synaptic and Cognitive Improvements by Inhibition of 2-AG Metabolism Are through Upregulation of MicroRNA-188-3p in a Mouse Model of Alzheimer’s Disease
Rongqing Chen*, Jian Zhang*, Ni Fan*, Zhao-Qian Teng*, Yan Wu*, Hongwei Yang, YaPing Tang, Hao Sun, Yunping Song, Chu Chen. 2013. Δ9-THC-Caused Synaptic and Memory Impairments Are Mediated through COX-2 Signaling
Changmei Liu, Zhao-Qian Teng, Andrea L McQuate, Emily M Jobe, Christa C Christ, Sergei J von Hoyningen-Huene, Marie D Reyes, Eric D Polich, Yina Xing, Yue Li, Weixiang Guo, Xinyu Zhao. 2013. An Epigenetic Feedback Regulatory Loop Involving MicroRNA195 and MBD1 Governs Neural Stem Cell Differentiation
Rongqing Chen, Jian Zhang, Yan Wu, Dongqing Wang, Guoping Feng, Ya-Ping Tang, Zhao-Qian Teng, Chu Chen. 2012. Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer’s Disease
Manavendra Pathania, Juan Torres-Reveron, Lily Yan, Tomoki Kimura, Tiffany V Lin, Valerie Gordon, Zhao-Qian Teng, Xinyu Zhao, Tudor A Fulga, David Van Vactor, Angélique Bordey. 2012. miR-132 enhances dendritic morphogenesis, spine density, synaptic integration, and survival of newborn olfactory bulb neurons
Weixiang Guo, Li Zhang, Devin M. Christopher, Zhao-Qian Teng, Sarah R. Fausett, Changmei Liu, Olivia L. George, John Klingensmith, Peng Jin, Xinyu Zhao. 2011. RNA binding protein FXR2 regulates proliferation and differentiation of adult hippocampal neural stem cells by repressing Noggin expression
Changmei Liu*, Zhao-Qian Teng*, Nicholas J. Santistevan, Keith E. Szulwach, Weixiang Guo, Peng Jin, Xinyu Zhao. 2010. Epigenetic Regulation of miR-184 by MBD1 Governs Neural Stem Cell Proliferation and Differentiation
Richard D. Smrt, Keith E. Szulwach, Rebecca L. Pfeiffer, Xuekun Li, Weixiang Guo, Manavendra Pathania, Zhao-Qian Teng, Yuping Luo, Junmin Peng, Angelique Bordey, Peng Jin, Xinyu Zhao. 2010. MicroRNA miR-137 Regulates Neuronal Maturation by Targeting Ubiquitin Ligase Mind Bomb-1