人物經(jīng)歷
2000-2003Uniformed Services University聯(lián)合培養(yǎng)博士藥理學(xué)
2003-2005南京大學(xué)醫(yī)藥生物技術(shù)國(guó)家重點(diǎn)實(shí)驗(yàn)室博士后生化與分子生物
2006-南京大學(xué)生命科學(xué)學(xué)院副教授、碩士生導(dǎo)師
2006南京大學(xué)青年骨干教師培養(yǎng)對(duì)象
2009中國(guó)藥理學(xué)會(huì)“施維雅”青年藥理學(xué)工作者獎(jiǎng)2009法國(guó)駐華領(lǐng)事“優(yōu)秀科技創(chuàng)新”人才獎(jiǎng)
學(xué)術(shù)兼職
江蘇省生物化學(xué)與分子生物學(xué)學(xué)會(huì)理事
世界中醫(yī)藥學(xué)會(huì)-中藥免疫學(xué)學(xué)會(huì)理事
中國(guó)藥理學(xué)會(huì)、江蘇省藥理學(xué)會(huì)會(huì)員
江蘇省科技咨詢(xún)專(zhuān)家
《中國(guó)藥理學(xué)報(bào)APS》《生化藥理學(xué)BP》等多種SCI期刊審稿人
南京大學(xué)碩士生導(dǎo)師
中國(guó)科協(xié)“分子影像技術(shù)在藥物研發(fā)中的作用” 青年科學(xué)家論壇執(zhí)行主席
國(guó)家級(jí)教育部科技獎(jiǎng)勵(lì)評(píng)審專(zhuān)家
中國(guó)博士后基金國(guó)家自然科學(xué)基金霍英東基金評(píng)審專(zhuān)家
南京科技創(chuàng)新領(lǐng)軍人才
研究方向
生化與分子藥理學(xué)、細(xì)胞生物學(xué)、生物化學(xué)與分子生物學(xué)
1：鈉鉀ATP酶及其配體的新生物學(xué)功能研究
2：炎癥因子mRNA轉(zhuǎn)錄后水平調(diào)控機(jī)制及其在藥物篩選中的應(yīng)用價(jià)值
3：小分子抗腫瘤或增敏劑活性物質(zhì)的尋找與機(jī)制研究
4: 中藥抗腫瘤分子藥理學(xué)
獲獎(jiǎng)情況
教學(xué)
2010年 南京大學(xué) “中國(guó)銀行獎(jiǎng)教金”
科研
2006 南京大學(xué)青年骨干教師培養(yǎng)對(duì)象
2009 中國(guó)藥理學(xué)會(huì)生物化學(xué)與分子藥理學(xué)優(yōu)秀論文一等獎(jiǎng)
2009 中國(guó)藥理學(xué)會(huì)“施維雅”青年藥理學(xué)工作者獎(jiǎng)
2009 法國(guó)駐華領(lǐng)事“優(yōu)秀科技創(chuàng)新”人才獎(jiǎng)
2010 江蘇省“青藍(lán)工程”學(xué)術(shù)骨干
2010 中國(guó)藥理學(xué)會(huì)臨床藥理學(xué)會(huì)議青年優(yōu)秀論文一等獎(jiǎng)
2011 教育部新世紀(jì)優(yōu)秀人才
2011 江蘇省“333”工程中青年科學(xué)技術(shù)帶頭人
2012 南京市創(chuàng)新型科技領(lǐng)軍人才
科研成果
論文
1. Cao D, Bian JJ, Hua ZC, Ma L, Chen W, Cheng S, Sun W, Jiao QC, and Yin W*. Modulation of TNF-a mRNA Stability by Human Antigen R and miR181s in Sepsis-Induced Immunoparalysis. EMBO mol Med. 2014 DOI - 10.15252/emmm.201404797 (5 year IF: 9.186)
2. Yin W, Cheng W, Shen W, Shu L, Zhao J, Zhang J, Hua ZC. Impairment of Na(+),K(+)-ATPase in CD95(APO-1)-induced human T-cell leukemia cell apoptosis mediated by glutathione depletion and generation of hydrogen peroxide. Leukemia. 2007; 21: 1669-78.(IF: 10.132)
3. Yin, W, Sonia, D., & Zhou, X. H2O2 is necessary but not sufficient to the stimulatory effect of low K on the Na,K-ATPase. J. Am. Soc. Nephrol. 2002;13:482. (IF:9.466)
4. Feng S, Chen W, Cao D, Gong FY, Cheng W, Chen S, Xu Q, Hua ZC, Yin W*.(2011) Involvement of Na,K-ATPase and its inhibitors in HuR-mediated cytokine mRNA stabilization in lung epithelial cells. Cell & Mol. Life Sci 68(1)：109-24 (IF:7.1)
5.Shi YL, Feng S, Chen W, Hua ZC, Bian JJ, Yin W*.Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-XL/p53-mediated amplification mechanisms. Cell Death Dis. 2014 Dec 18;5:e1579. doi: 10.1038/cddis.2014.547. (IF: 6.1)
6. Chen W., Ma L, Feng S, Cao D, Hua ZC, and Yin W. General Control Non-Depressing Kinase 2 Generates Auto-Amplification Loop in Cancer Cell Apoptosis by Posttranslational Mechanisms. Molecular biology of the Cell. 2015 (accepted)(5-year IF: 5.1)
7. Yin W, Li X, Feng S, Cheng W, Tang B, Shi YL, Hua ZC. Plasma membrane depolarization and Na,K-ATPase impairment induced by mitochondrial toxins augment leukemia cell apoptosis via a novel mitochondrial amplification mechanism. Biochem Pharmacol. 2009; 78: 191-202. (IF:4.9)
8. Deng X, Yin F, Lu X, Cai B, Yin W*. The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway. Toxicol Sci. 2006; 91: 59-69.(IF:4.7)
9. Yin W*, Yin FZ, Shen WX, Cai BC, Hua ZC. Requirement of hydrogen peroxide and Sp1 in the stimulation of Na,K-ATPase by low potassium in MDCK epithelial cells. Int J Biochem Cell Biol. 2008; 40: 942-53. (IF:4.9)
10. Yin W*, Deng XK, Yin FZ, Zhang XC, Cai BC. The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells. Food Chem Toxicol. 2007; 45: 1700-8.
11. Yin W, Deng XK, Li WD, Yin FZ, Lu XY, Zhang XC, Hua ZC, Cai BC. The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism. J Ethnopharmacol. 2006; 106: 179-86.
12. Yin W, Wang TS, Yin FZ, Cai BC. Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica. J Ethnopharmacol. 2003; 88: 205-14.
13. Yin FZ#, Yin W#, Zhang X,Lu TL, Cai BC. Development of an HPLC fingerprint for quality control and species differentiation of Fructus schisandrae Acat chromatographia 2010;22(4):609-621. 共同第一作者
14. Yin W, Jiang G, Takeyasu K, Zhou X. Stimulation of Na,K-ATPase by low potassium is dependent on transferrin. J Membr Biol 2003;193:177-84.
15. Yin W, Cai BC. Role of transferrin in the stimulation of Na,K-ATPase induced by low K+ in Madin Darby canine kidney cells. Acta. Physiol. Sin. 2003; 55: 481-6. (IF:0.6)
16. Yin, W, Yin, FZ., & Cai BC, The mechanism of cytotoxicity of human embryonic kidney cells induced by brucine. Chin. J. Pharmacol. & Toxicol. 2003,17(5):321-327
17. Yin FZ, Lu TL, Cai BC, and Yin W*. Development of a quality control method for Schisandrae chinensis fructus with micellar electrokinetic capillary chromatography. Acta pol. Pharm. 2014 accepted.
18. Yin FZ, Lu TL, Li L, Cai BC, and Yin W*. Quality control of Gardeniae Fructus by HPLC-PDA fingerprint coupled with chemometric methods. Journal of chromatographic science. 2014 accepted
19. Shu L, Yin W, Zhang J, Tang B, Kang YX, Ding F, Hua ZC. Sinomenine inhibits primary CD4+ T-cell proliferation via apoptosis. Cell Biol Int. 2007; 31: 784-9.
20. Li S, Dong W, Zong Y, Yin W, Jin G, Hu Q, Huang X, Jiang W, Hua ZC. Polyethylenimine-complexed plasmid particles targeting focal adhesion kinase function as melanoma tumor therapeutics. Mol Ther. 2007; 15: 515-23.
專(zhuān)著
《酶的凝膠電泳檢測(cè)手冊(cè)》化學(xué)工業(yè)出版社 編委
《藥食本草》中國(guó)中醫(yī)藥科技出版社 副主編
《基因工程實(shí)驗(yàn)創(chuàng)新教材》 知識(shí)出版社 主編
專(zhuān)利
1. ZL201010235528.9，第一發(fā)明人
2. ZL20100242655.1，第一發(fā)明人
3. ZL201010241247.4，第一發(fā)明人
4.蟾蜍甾二烯類(lèi)化合物在制備治療膿毒癥免疫麻痹藥物中的用途,201310693592.2，第一發(fā)明人
5.強(qiáng)心甾類(lèi)化合物在制備治療膿毒癥免疫麻痹藥物中的用途，201310597606.3 ，第一發(fā)明人
6.miR181s在制備治療急性腸炎藥物中的應(yīng)用，201310654116.2，第一發(fā)明人
7.一種用于治療膿毒癥急性肺損傷的小核酸藥物，201310652876.X ，第一發(fā)明人
8.以NLRP3為靶點(diǎn)的藥物篩選細(xì)胞模型及其應(yīng)用，201310695899.9 ，第一發(fā)明人
9.他克莫斯FK506在制備治療非小細(xì)胞肺癌藥物中的應(yīng)用，201310674818.7，第一發(fā)明人
10.一種五味子有機(jī)酸分析方法，201310654107.3，第二發(fā)明人
11.4-氧代戊酸在制備止瀉藥物中的用途，201310654108.8，第二發(fā)明人
