研究方向
1、胚胎干細胞和誘導多能干細胞定向分化體系
2、疾病特異性誘導多能干細胞
3、神經(jīng)元退行性疾病動物模型
4、轉(zhuǎn)基因與基因敲除動物模型的研究
簡歷
1992-1997，北京醫(yī)科大學臨床醫(yī)學學士
1997-2002，中國協(xié)和醫(yī)科大學理學博士
2002-2008，美國ST JUDE兒童研究醫(yī)院博士后
2009-今， 中國科學院生物物理研究所研究員
研究組工作方向
1、胚胎干細胞和誘導多能干細胞定向分化體系的研究
2、疾病特異性誘導多能干細胞的研究
3、神經(jīng)元退行性疾病動物模型的研究
4、轉(zhuǎn)基因與基因敲除動物模型的研究
代表性論文
1. Zhang Q, Wu J, Wu R, Ma J, Du G, Jiao R, Tian Y, Zheng Z, Yuan Z. DJ-1 promotes the proteasomal degradation of Fis1: implications of DJ-1 in neuronal protection. Biochem J.
2. Winter H, Rüttiger L, Müller M, Kuhn S, Brandt N, Zimmermann U, Hirt B, Bress A, Sausbier M, Conscience A, Flamant F, Tian Y, Zuo J, Pfister M, Ruth P, L wenheim H, Samarut J, Engel J, Knipper M. Deafness in TRbeta mutants is caused by malformation of the tectorial membrane. J Neurosci
3. Tian Y, Pate C, Andreolotti A, Wang L, Tuomanen E, Boyd K, Claro E and Jackowski S. Cytokine Secretion Requires Phosphatidylcholine Synthesis. J Cell Biol
4. Gunter C, Frank M, Tian Y, Murti KG, Rehg JE, Jackowski S. Probucol therapy overcomes the reproductive defect in CTP: phosphocholine cytidylyltransferase beta2 knockout mice. Biochim Biophys Acta.
5. Gao J, Maison SF, Wu X, Hirose K, Jones SM, Bayazitov I, Tian Y, Mittleman G, Matthews DB, Zakharenko SS, Liberman MC, Zuo J. Orphan glutamate receptor delta1 subunit required for high-frequency hearing. Mol Cell Biol
6. Tian Y, Zhou R, Rehg JE, Jackowski S. Role of phosphocholine cytidylyltransferase alpha in lung development. Mol Cell Biol.
7. Tian Y, Jackson P, Gunter C, Wang J, Rock CO, Jackowski S.Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2. J Biol Chem
8. Chow LM, Tian Y, Weber T, Corbett M, Zuo J, Baker SJ. Inducible Cre recombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells. Dev Dyn.
9. Tian Y, James S, Zuo J, Fritzsch B, Beisel KW. Conditional and inducible gene recombineering in the mouse inner ear. Brain Res
10. Tian Y, Li M, Fritzsch B, Zuo J. Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing Prestin. Dev Dyn
11. Li M*, Tian Y*, Fritzsch B, Gao J, Wu X, Zuo J. Inner hair cell Cre-expressing transgenic mouse. Genesis.
12. Tian Y, Breedveld GJ, Huang S, Oostra BA, Heutink P, Lo WH. Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome
13. Zhao H*, Tian Y*, Breedveld G, Huang S, Zou Y, Y J, Chai J, Li H, Li M, Oostra BA, Lo WH, Heutink P. Postaxial polydactyly type A/B (PAP-A/B) is linked to chromosome
14. Tian Y, Zhao H, Chen J, Liu Y, Li M, Yang T, Luo H, Huang S. Cloning of a novel zinc finger gene ZNF333 and its expression analysis. Basic Medical Sciences and Clinics
15. Tian Y, Huang S. Current advances in genetic analysis of hereditary spastic paraplegia. Foreign Medical Sciences