個人經(jīng)歷
1997年獲瑞典卡羅林斯卡學院博士學位，并在瑞典卡羅林斯卡學院先后任研究員、高級研究員
2009年獲北京市高校高層次人才稱號。主要從事腦重大疾�。ㄒ钟舭Y、癲癇等）中神經(jīng)肽及受體的作用及其分子機制研究。主持973子課題、國家自然科學基金等課題項目。已在PNAS等重要國際學術雜志上發(fā)表了50余篇學術論文(總影響因子約270，總引用超過2000次, H因子=27)。
研究方向名稱：神經(jīng)遞質(zhì)受體和重大腦病
社會任職
1.中國神經(jīng)科學學會理事
2.中國生理學會外事工作委員會委員
個人簡歷
1. 199112-199709:瑞典卡羅琳斯卡醫(yī)學院神經(jīng)科學系 博士生, 博士學位
2. 199709-199909:瑞典卡羅琳斯卡醫(yī)學院神經(jīng)科學系 博士后
3. 199909-200109:瑞典卡羅琳斯卡醫(yī)學院醫(yī)學生化和生物物理系 博士后
4. 200109-200707:瑞典卡羅琳斯卡醫(yī)學院神經(jīng)科學系 Forskare(研究員)
5. 200110- :中國科學院神經(jīng)科學研究所客座研究員
6. 200112- :華中科技大學兼職教授
7. 200702- :首都醫(yī)科大學神經(jīng)生物學系 特聘教授
重要學術論文
| 1. Huang HP, Wang SR, Yao W, Zhang C, Zhou Y, Chen XW, Zhang B, Xiong W, Wang LY, Zheng LH, Landry M, Hokfelt T, Xu Z-Q D(徐志卿）, Zhou Z.Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices. Proc Natl Acad Sci U S A. 2007,104:1401-1406.SCI |
| 2. Swanson CJ, Blackburn TP, Zhang X, Zheng K, Xu Z-QD(徐志卿）, Hokfelt T, Wolinsky TD, Konkel MJ, Chen H, Zhong H, Walker MM, Durkin M, Artymyshyn RP, Smith KE, Jones KJ, Craig DA, Gerald CP, Brancheck TA .From The Cover: Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.. Proc Natl Acad Sci U S A . 2005,102:17489-17494.SCI |
| 3. Xia S, Kjaer S, Zheng K, Hu PS, Xu T, Hokfelt T, Xu Z-Q D(徐志卿）*.Constitutive and ligand-induced internalization of EGFP-tagged galanin R2 and Rl receptors in PC12 cells.. Neuropeptides. 2005,39:173-178.SCI |
| 4. Zheng K, Kuteeva E, Xia S, Bartfai T, Hokfelt T, Xu Z-Q D(徐志卿）*.Age-related impairments of synaptic plasticity in the lateral perforant path input to the dentate gyrus of galanin overexpressing mice.. Neuropeptides. 2005,39:259-267.SCI |
| 5. Lundstrom L, Sollenberg U, Brewer A, Kouya PF, Zheng K, Xu XJ, Sheng X, Robinson JK, Wiesenfeld-Hallin Z, Xu Z-Q D(徐志卿）, Hokfelt T, Bartfai T, Langel U.A galanin receptor subtype 1 specific agonist.. International journal of peptide research and therapeutics . 2005,11:17-27.SCI |
| 6. Xia S, Kjaer S, Kang Z, Hu P-S, Bai L, Jia J, Rigler R, Pramanik A, Xu T, Hokfelt T, Xu Z-Q D(徐志卿）*.Visualization of a functionally enhanced GFP-tagged galanin R2 receptor in PC12 cells: Constitutive and ligand-induced internalization.. Proc Natl Acad Sci U S A . 2004,101:15207-15212.SCI |
| 7. Xia S, Xu L, Bai L, Xu Z-Q D(徐志卿）, Xu, T.Labeling and dynamic imaging of synaptic vesicle-like microvesicles in PC12 cells using TIRFM analysis. . Brain Res. 2004,997:159-164.SCI |
| 8. Bao L, Jin S-X, Zhang C, Wang L-H, Xu Z-Z, Zhang F-X, Wang L-C, Ning F-S, Cai H-J, Guan J-S, Xiao H-S, Xu Z-Q D, He C, Hokfelt T, Zhou Z and Zhang X.Activation of delta-opioid receptors induces receptor insertion and neuropeptide secretion.. Neuron. 2003,37:121-133.SCI |
| 9. Fetissov S.O., Xu Z-Q D(徐志卿）, Byrne L.C., Hassani H., Ernfors P. and Hokfelt T.NPY targets in the hypothalamus.Nitric oxide synthesizing neurons express Y1 receptor. . J Neuroendocrinology . 2003,15:754-760.SCI |
| 10. Kopp J, Xu Z-Q D(徐志卿）, Zhang X, Pedrazzini T, Herzog H, Kresse A, Wang H, Walsh J, Hokfelt T .Expression of neuropeptide Y1 receptor in the CNS of rat, wild type and Y1 receptor knock-out mouse. Focus on immunohistochemical localization. . Neuroscience . 2002,111:443-532.SCI |
| 11. Ma X, Tong Y-G, Schmidt R, Brown W, Payza K, Hodzic L, Pou C, Godbout C, Hokfelt T, Xu Z-QD(徐志卿）*.Effects of galanin receptor agonists on locus coeruleus neurons.. Brain Res . 2001,919:169-174.SCI |
| 12. Kokaia M, Holmberg K, Nanobashvili A, Xu Z-Q D(徐志卿）, Kokaia Z, Lendahl U, Hilke S, Theodorsson E, Kahl U, Bartfai T, Lindvall O, Hokfelt T.Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin.. Proc Natl Acad Sci U S A . 2001,98:14006-14011.SCI |
| 13. Lindgren N, Xu Z-Q D(徐志卿）, Herrere-Marschitz M, Haycock J, Goldstein M, Hokfelt T, Fisone G .Dopamine D2 receptors regulate tyrosine hydroxylase activity and phosphorylation at Ser40 in rat striatum. Eur J Neurosci . 2001,13:773-780.SCI |
| 14. Shi T-J S, Tandrup T, Bergman E, Xu Z-Q D(徐志卿）, Ulfhake B, Hokfelt T.Effect of peripheral nerve injury on neuronal cell numbers and neuropeptide expression in mouse dorsal root ganglia. . Neuroscience . 2001,105:249-263.SCI |
| 15. Xu Z-Q D(徐志卿）*, Tong Y-G, Hokfelt T.Galanin enhances noradrenaline-induced outward current on locus coeruleus noradrenergic neurons. Neuroreport. 2001,12:1779-1782.SCI |
| 16. Lindgren N, Xu Z-Q D(徐志卿）, Lindskog M, Herrere-Marschitz M, Goiny M, Haycock J, Goldstein M, Hokfelt T, Fisone G.Regulation of tyrosine hydroxylase activity and phosphorylation at Ser19 and Ser40 via activation of glutamate NMDA receptors in rat striatum.. J Neurochem . 2000,74:2470-2477.SCI |
| 17. Xu Z-Q D（徐志卿）*, Ma X, Soomets U, Langel U, Hokfelt T.Electrophysiological evidence for a hyperpolarizing, galanin (1-15)-selective receptor on hippocampal CA3 pyramidal neurons.. Proc Natl Acad Sci U S A. 1999,96:14583-14587.SCI |
| 18. Xu Z-Q D(徐志卿）, Shi TJ, Hokfelt T.Galanin/GMAP- and NPY-like immunoreactivities in locus coeruleus and noradrenergic nerve terminals in the hippocampal formation and cortex with notes on the galanin-R1 and -R2 receptors. . J Comp Neurol . 1998,392:227-251.SCI |
| 19. Shi TJ, Holmberg K, Xu Z-Q D(徐志卿）, Steinbusch H, de Vente J, Hokfelt T.Effect of peripheral nerve injury on cGMP and nitric oxide synthase levels in rat dorsal root ganglia: time course and coexistence.. Pain. 1998,78:171-180.SCI |
| 20. Xu Z-Q D(徐志卿）, Zhang X, Pieribone VA, Grillner S, Hokfelt T.Galanin-5-hydroxytryptamine interactions: electrophysiological, immunohistochemical and in situ hybridization studies on rat dorsal raphe neurons with a note on galanin R1 and R2 receptors.. Neuroscience . 1998,87:79-94.SCI |
| 21. Xu Z-Q D(徐志卿）, Lew JY, Harada K, Aman K, Goldstein M, Deutch A, Haycock JW, Hokfelt T.Immunohistochemical studies on phosphorylation of tyrosine hydroxylase in central catecholamine neurons using site- and phosphorylation state-specific antibodies.. Neuroscience . 1998,82:727-738.SCI |
| 22. Xu Z-Q D(徐志卿）*, Bartfai T, Langel U, Hokfelt T.Effects of three galanin analogs on the outward current evoked by galanin in locus coeruleus.. Ann N Y Acad Sci . 1998,863:459-465.SCI |
| 23. Xu Z-Q D(徐志卿）*, de Vente J, Steinbusch H, Grillner S, Hokfelt T .The NO-cGMP pathway in the rat locus coeruleus: electrophysiological, immunohistochemical and in situ hybridization studies.. Eur J Neurosci. 1998,10:3508-3516.SCI |
| 24. Xu Z-Q D(徐志卿）* and Hokfelt T.Expression of galanin and nitric oxide synthase in subpopulations of serotonin neurons of the rat dorsal raphe nucleus.. J Chem Neuroanat . 1997,13:169-187.SCI |
| 25. Yamada K, Xu Z-Q(徐志卿）, Zhang X, Gustafsson L, Hulting AL, de Vente J, Steinbusch HW, Hokfelt T.Nitric oxide synthase and cGMP in the anterior pituitary gland: effect of a GnRH antagonist and nitric oxide donors.. Neuroendocrinology . 1997,65:147-156.SCI |
| 26. Shi TJ, Zhang X, Holmberg K, Xu Z-Q D(徐志卿）, Hokfelt T. Expression and regulation of galanin-R2 receptors in rat primary sensory neurons: effect of axotomy and inflammation.. Neurosci Lett . 1997,237:57-60.SCI |
| 27. Xu Z-Q D(徐志卿）, Zhang X, Grillner S, Hokfelt T.Electrophysiological studies on rat dorsal root ganglion neurons after peripheral axotomy: changes in responses to neuropeptides.. Proc Natl Acad Sci U S A. 1997,94:13262-13266.SCI |
| 28. Bao L, Kopp J, Zhang X, Xu Z-Q D(徐志卿）, Zhang LF, Wong H, Walsh J, Hokfelt T. Localization of neuropeptide Y Y1 receptors in cerebral blood vessels. Proc Natl Acad Sci U S A . 1997,94:12661-12666.SCI |
| 29. Xu Z-Q(徐志卿）, Shi TJ, Hokfelt T.Expression of galanin and a galanin receptor in several sensory systems and bone anlage of rat embryos.. Proc Natl Acad Sci U S A. 1996,93:14901-14905.SCI |
| 30. Xu Z-Q(徐志卿）, Shi TJ, Landry M, Hokfelt T .Evidence for galanin receptors in primary sensory neurones and effect of axotomy and inflammation.. Neuroreport . 1996,8:237-242 .SCI |
| 31. Pieribone VA, Xu Z-Q(徐志卿）, Zhang X, Grillner S, Bartfai T, Hokfelt T.Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice. Neuroscience. 1995,64:861-874. |
| 32. Zhang X, Xu Z-Q(徐志卿）, Bao L, Dagerlind A, Hokfelt T.Complementary distribution of receptors for neurotensin and NPY in small neurons in rat lumbar DRGs and regulation of the receptors and peptides after peripheral axotomy. J Neurosci . 1995,15:2733-2747.SCI |
| 33. Xu Z-Q(徐志卿）, Pieribone VA, Zhang X, Grillner S, Hokfelt T.A functional role for nitric oxide in locus coeruleus: immunohistochemical and electrophysiological studies. Exp Brain Res. 1994,98:75-83. |