王江云，研究員。

2007-current 生物物理所結(jié)構(gòu)生物學與分子生物學研究中心 研究員

2003-2007 博士后, Scripps 研究所

1998-2003 化學博士, Univ. of Illinois at Urbana Champaign

1994-1998 化學物理學士, 中國科技大學少年班零零班

通過進化tRNA和tRNA synthetase, 我擴展了基因密碼, 使得在活細胞中的TAG停止密碼子可以編碼熒光氨基酸,有化學反應(yīng)性的氨基酸和羥基酸. 這些技術(shù)使得我們可以在活細胞中定位不能用綠色熒光蛋白定位的蛋白質(zhì); 制備脂化或糖化的蛋白質(zhì); 并且研究蛋白折疊和酶學。 同時通過從頭設(shè)計的方法, 我也設(shè)計了含有heme的蛋白質(zhì), 并且用NMR的方法測定了結(jié)構(gòu)。

科技部973 “表觀遺傳學的化學生物學研究”，任課題組長。

科技部973 “基因密碼子的分子生物學研究”，任課題骨干。

中國科學院重點部署項目 “非編碼RNA”，任項目首席。

國家自然科學基金委 “杰出青年基金”，任課題負責人。

國家自然科學基金委“重大研究計劃培育項目”，任課題負責人

1. Lv, X. X.; Yu, Y.; Zhou, M.; Hu, C.; Gao, F.; Li, J. S.; Liu, X. H.; Deng, K.; Zheng, P.; Gong, W. M.; Xia, A. D.; Wang, J. Y.* Ultrafast Photo-induced Electron Transfer in Green Fluorescent Protein Bearing a Genetically Encoded Electron Acceptor

2. Yu, Y.; Zhou, Q.; Wang, L;.Liu, X.; Zhang, W.; Hu, M. ; Dong, J. ; Li, J.; Lv, X.; Ouyang, H.; Li, H.; Gao, F; Gong, .W.; Lu, Y.; Wang, J. Y*, Significant Improvement of Oxidase Activity through the Genetic Incorporation of a Redox-active Unnatural Amino Acid

3. Yu, Y.; Lv, X. X.; Li, J. S.; Zhou, Q.; Cui, C.; Hosseinzadeh, P.; Mukherjee, A.; Nilges, M. J.; Wang, J. Y.* and Lu, Y.* Defining the Role of Tyrosine and Rational Tuning of Oxidase Activity by Genetic Incorporation of Unnatural Tyrosine Analogs

4. Li, F. H.; Dong, J. S.; Hu, X.; Gong, W. M.; Li, J.S.; Shen, J.; Tian, H.; and Wang, J. Y. * A Covalent Approach for Site-Specific RNA Labeling in Mammalian Cells

5. Liu, X. H.; Jiang, L..; Li, J.; Wang, L.; Yu, Y.; Zhou, Q.; Lv, X. X.; Gong, W. M.; Lu, Y.; Wang, J.Y. *. Significant Expansion of Fluorescent Protein Sensing Ability through the Genetic Incorporation of Superior Photo-Induced Electron-Transfer Quenchers

6. Pan, Y.; Jin, J.; Yu, Y.; Wang, J. Y.*. Significant Enhancement of hPrx1 Chaperone Activity through Lysine Acetylation. ChemBioChem

7. Hu, C; Chan, S.; Sawyer, E. B.; Yu, Y.; Wang, J. Y. *. Metalloprotein design using genetic code expansion

8. Wu, F.C.; Zhang, H; Zhou, Q.; Wu, M; Ballard, Z; Tian, Y ; Wang, J. Y. ; Niu, ZW; Huang, Y. Expanding the genetic code for site-specific labelling of tobacco mosaic virus coat protein and building biotin-functionalized virus-like particles

9. Li,F. H.; Zhang, H.; Sun, Y.; Pan, Y. C. ; Zhou, J. Z.; J. Y. Wang* Expanding the Genetic Code for Photoclick Chemistry in E. coli, Mammalian Cells, and A

10. Li, F. H., Shi P., Li J. S.,Yang F., Wang T. Y., Zhang W., Gao F., Ding W., Li D., Li J., Xiong Y., Sun J. P., Gong W. M.*, Tian C. L.*, Wang J. Y.*A Genetically Encoded 19F NMR Sensor for Tyrosine Phosphorylation

11. Liu, X. H., Li J. S., Wang J. Y.*Significant Expansion of the Fluorescent Protein Chromophore through the Genetic Incorporation of an Unnatural Amino Acid

12. Zhou Q., Hu M. R., Zhang W., Jiang, L., Perrett S., Zhou J., Wang J. Y.*Probing the Function of the Tyr-Cys Crosslink in Metalloenzymes through the Genetic Incorporation of 3-Methylthiotyrosine

13. Liu, X. H., Yu, Y., Hu, C., Zhang, W., Lu, Y.*, Wang J. Y.*Significant Increase of Oxidase Activity through the Genetic Incorporation of a Tyrosine-Histidine Cross-Link in a Myoglobin Model of Heme-Copper Oxidase

14. Liu, X. H., Li, J. S., Dong, J. S., Hu , C., Gong, W. M.*, Wang, J. Y.* Genetic Incorporation of a Metal Chelating Amino Acid as a Probe for Protein Electron Transfer. Angew. Chem. Intl. Ed

15. Yu, Z., Pan, Y. C., Wang. Z. Y., Wang, J. Y.*, Lin. Q.*Genetically Encoded Cyclopropene Directs Rapid, Photoclick Chemistry- Mediated Protein Labeling in Mammalian Cells

16. Wang, J. Y.*, Zhang, W., Song, W. J., Wang, Y. Z., Yu, Z. P., Li, J. S., Wu, M. H., Wang, L., Zang, J. Y., Lin, Q.*A Biosynthetic Route to Photoclick Chemistry on Proteins