人物經(jīng)歷
1979年11月生，博士，昆明理工大學(xué)生命科學(xué)與技術(shù)學(xué)院，教授。
2009年9月- 2011年10月：于上海交通大學(xué)微生物代謝國家重點(diǎn)實(shí)驗(yàn)室從事博士后研究，主要從事高等真菌次級代謝產(chǎn)物的代謝工程研究。
2004年9月- 2009年9月：就讀于華東理工大學(xué)生物反應(yīng)器工程國家重點(diǎn)實(shí)驗(yàn)室，生物化工專業(yè)，獲得工學(xué)博士學(xué)位。
2001年9月- 2004年7月：就讀于青島化工學(xué)院化學(xué)工程學(xué)院，生物化工專業(yè)，獲得碩士學(xué)位。
1997年9月- 2001年7月： 就讀于河南大學(xué)生物系，發(fā)酵工程專業(yè)，獲得學(xué)士學(xué)位。
學(xué)術(shù)兼職
擔(dān)任《Biotechnology & Bioengineering》,《Bioresource Technology》,《Microbial Cell Factories》, 《Biochemical Engineering Journal》,《Process Biochemistry》, 《Bioprocess and Biosystems Engineering》,《Biotechnology and Applied Biochemistry》, 《Applied Biochemistry and Biotechnology》, 《Fungal Biology》,《Pharmaceutical Biology》等10多本SCI期刊的特邀審稿人。
研究方向
應(yīng)用微生物，生物技術(shù)，生物制藥，微生物代謝工程。
利用云南省微生物資源的優(yōu)勢，篩選生產(chǎn)生物活性物質(zhì)的藥用真菌。建立微生物深層培養(yǎng)的方法，實(shí)現(xiàn)活性物質(zhì)生物反應(yīng)器規(guī)模的大量生產(chǎn)。結(jié)合基因組學(xué)和功能基因組學(xué)技術(shù)研究生物活性物質(zhì)的合成調(diào)控機(jī)制，并以此為基礎(chǔ)改造微生物的代謝途徑，實(shí)現(xiàn)活性物質(zhì)代謝流量的最大化。
目前以高等藥用真菌靈芝為研究對象，通過基因工程和代謝工程的方法解析生物活性物質(zhì)靈芝酸（抗癌等功能）和靈芝多糖（增強(qiáng)免疫力等功能）的生物合成調(diào)控機(jī)制，構(gòu)建高產(chǎn)工程菌株并實(shí)現(xiàn)其規(guī)�；a(chǎn)。
榮譽(yù)記錄
貴州省科技進(jìn)步一等獎（排名第3），伍達(dá)觀先進(jìn)教師獎，紅云園丁優(yōu)秀教師獎。主要貢獻(xiàn)
承擔(dān)科研項(xiàng)目情況
目前主持國家自然科學(xué)基金《靈芝中靈芝酸生物合成相關(guān)P450基因的鑒定與功能研究》、《靈芝細(xì)胞菌絲形態(tài)對抗癌物質(zhì)靈芝酸發(fā)酵過程的調(diào)控及其影響機(jī)制》兩項(xiàng)，云南省科技廳項(xiàng)目一項(xiàng)，2012年云南省高層次引進(jìn)人才資助項(xiàng)目一項(xiàng)
代表性論文和專著（* 通訊作者）
1.De-Huai Zhang, Lu-Xi Jiang, Na Li, Xuya Yu, Peng Zhao, Tao Li,Jun-Wei Xu*(2017) Overexpression of the squalene epoxidase gene alone and in combination with the 3-hydroxy-3-methylglutaryl coenzyme A gene increases ganoderic acid production inGanoderma lingzhi. Journal of Agricultural and Food Chemistry, 65: 4683-4690
2.De-Huai Zhang,Na Li,Xuya Yu,Peng Zhao,Tao Li,Jun-Wei Xu*(2017) Overexpression of the homologous lanosterol synthase gene in ganoderic acid biosynthesis in Ganoderma lingzhi. Phytochemistry, 134: 46-53
3. Huan-Jun Li, Yi-Long He, De-Huai Zhang, Tong-Hui Yue, Lu-Xi Jiang, Na Li,Jun-Wei Xu*(2016) Enhancement of ganoderic acid production by constitutively expressing Vitreoscilla hemoglobin gene in Ganoderma lucidum. Journal of Biotechnology, 227: 35-40
4. Huan-Jun Li, De-Huai Zhang, Tong-Hui Yue, Lu-Xi Jiang, Xuya Yu, Peng Zhao, Tao Li,Jun-Wei Xu*(2016) Improved polysaccharide production in a submerged culture of Ganoderma lucidum by the heterologous expression of Vitreoscilla hemoglobin gene. Journal of Biotechnology, 217: 132-137
5. Huan-Jun Li, De-Huai Zhang, Li-Liang Han, Xuya Yu, Peng Zhao, Tao Li, Jian-Jiang Zhong,Jun-Wei Xu*(2016) Further improvement in ganoderic acid production in static liquid culture of Ganoderma lucidum by integrating nitrogen limitation and calcium ion addition. Bioprocess and Biosystems Engineering, 39: 75-80
6.Jun-Wei Xu*,Jian-Jiang Zhong (2015) Genetic engineering of Ganoderma lucidum for the efficient production of ganoderic acids. Bioengineered, 6: 357-360
7.Jun-Wei Xu*, Sen-Lin Ji, Huan-Jun Li, Meng-Fei Ren, Yan-Qing Duan, Li-Zhi Dang, Ming-He Mo (2015) Increased polysaccharide production and biosynthetic gene expressions in a submerged culture of Ganoderma lucidum by the overexpression of the homologous alpha-phosphoglucomutase gene. Bioprocess and Biosystems Engineering, 38: 399-405
8. Sen-Lin Ji, Rui Liu, Meng-Fei Ren, Huan-Jun Li,Jun-Wei Xu*(2015) Enhanced production of polysaccharide through the overexpression of the homologous UDP glucose pyrophosphorylase gene in a submerged culture of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher basidiomycetes). International Journal of Medicinal Mushrooms, 17: 435-442
9. Jiang-Sheng Zhou, Sen-Lin Ji, Meng-Fei Ren, Yi-Long He, Xiao-Ran Jing,Jun-Wei Xu*(2014) Enhanced accumulation of individual ganoderic acids in a submerged culture of Ganoderma lucidum by the overexpression of squalene synthase gene. Biochemical Engineering Journal, 90: 178-183
10. Xuya Yu, Sen-Lin Ji, Yi-Long He, Meng-Fei Ren,Jun-Wei Xu*(2014) Development of an expression plasmid and its use in genetic manipulation of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher basidiomycetes). International Journal of Medicinal Mushrooms, 16: 161-168
11. Yan-Qing Duan, Zhan-Chang Xing,Jun-Wei Xu*(2013) Screening of a high yield polysaccharide strain from ten edible and medicinal fungi and optimization of its culture conditions. Research Journal of Biotechnology, 8:11-15
12.Jun-Wei Xu, Yi-Ning Xu, Jian-Jiang Zhong (2012) Enhancement of ganoderic acid accumulation by overexpression of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase gene in the basidiomycete Ganoderma lucidum. Applied and Environmental Microbiology, 78: 7968-7976
13.Jun-Wei Xu, Wei Zhao, Yi-Ning Xu, Jian-Jiang Zhong (2012) Isolation and analysis of differentially expressed genes during asexual sporulation in liquid static culture of Ganoderma lucidum by suppression subtractive hybridization. Molecular Biology Reports, 39: 3603-3610
14.Jun-Wei Xu, Wei Zhao, Jian-Jiang Zhong (2011) Isolation and characterization of a novel Ganoderma lucidum gene that differentially expressed between shaking culture and liquid static culture. Genes & Genomics, 33: 645-651
15.Jun-Wei Xu, Wei Zhao, Jian-Jiang Zhong (2010) Biotechnological production and application of ganoderic acids. Applied Microbiology and Biotechnology, 87: 457-466
16.Jun-Wei Xu, Yi-Ning Xu, Jian-Jiang Zhong (2010) Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. Applied Microbiology and Biotechnology, 85: 941-948
Resume
Contact Information：
Name: Jun-Wei Xu
Degree: Ph.D.
Position & Title: Professor of Bioengineering
Education:
2009.9-2011.10, Post-doctor, The State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong
University.
2004.9-2009.9, Ph.D., Biochemical Engineering, The State Key Laboratory of Bioreactor Engineering,
East China University of Science and Technology.
2001.9-2004.7, M.S., Biochemical Engineering, Qingdao University of Science and Technology.
1997. 9-2001.7, B.S., Fermentation Engineering, Henan University.
Research Interests:
1. Applied Microbiology
2. Biotechnology
3. Microbial metabolic engineering
Research Profile:
1. Screening of new strains with industrial potential for producing bioactive compounds.
2. Submerged fermentation of higher fungi for production of valuable bioactive compounds in bioreactor.
3. Elucidation of the biosynthesis and regulatory mechanism of bioactive compounds in higher fungi by
comparative genomic analysis, proteomic analysis and metabolic flux analysis.
4. Metabolic engineering of bioactive compounds-producing higher fungi.
Research Project:
Two projects from National Natural Science Foundation of China (NSFC) and one project from Yunnan Provincial Science and Technology Department.
Awards:
1st-Class Award for the Advancement of Science and Technology by Guizhou Province (2016)
SCI-Journal Reviewer:
Bioresource Technology; Biotechnology & Bioengineering; Microbial Cell Factories; Biochemical Engineering Journal; Process Biochemistry; Bioprocess and Biosystems Engineering; Biotechnology and Applied Biochemistry; Applied Biochemistry and Biotechnology; Fungal Biology; Pharmaceutical Biology; Interdisciplinary Sciencesu2013Computational Life Sciences
Publications (* Corresponding author):
1.De-Huai Zhang, Lu-Xi Jiang, Na Li, Xuya Yu, Peng Zhao, Tao Li,Jun-Wei Xu*(2017) Overexpression of the squalene epoxidase gene alone and in combination with the 3-hydroxy-3-methylglutaryl coenzyme A gene increases ganoderic acid production inGanoderma lingzhi.Journal of Agricultural and Food Chemistry, 65: 4683-4690
2.De-Huai Zhang,Na Li,Xuya Yu,Peng Zhao,Tao Li,Jun-Wei Xu*(2017) Overexpression of the homologous lanosterol synthase gene in ganoderic acid biosynthesis in Ganoderma lingzhi. Phytochemistry, 134: 46-53
3. Huan-Jun Li, Yi-Long He, De-Huai Zhang, Tong-Hui Yue, Lu-Xi Jiang, Na Li,Jun-Wei Xu*(2016) Enhancement of ganoderic acid production by constitutively expressing Vitreoscilla hemoglobin gene in Ganoderma lucidum. Journal of Biotechnology, 227: 35-40
4. Huan-Jun Li, De-Huai Zhang, Tong-Hui Yue, Lu-Xi Jiang, Xuya Yu, Peng Zhao, Tao Li,Jun-Wei Xu*(2016) Improved polysaccharide production in a submerged culture of Ganoderma lucidum by the heterologous expression of Vitreoscilla hemoglobin gene. Journal of Biotechnology, 217: 132-137
5. Huan-Jun Li, De-Huai Zhang, Li-Liang Han, Xuya Yu, Peng Zhao, Tao Li, Jian-Jiang Zhong,Jun-Wei Xu*(2016) Further improvement in ganoderic acid production in static liquid culture of Ganoderma lucidum by integrating nitrogen limitation and calcium ion addition. Bioprocess and Biosystems Engineering, 39: 75-80
6.Jun-Wei Xu*,Jian-Jiang Zhong (2015) Genetic engineering of Ganoderma lucidum for the efficient production of ganoderic acids. Bioengineered, 6: 357-360
7.Jun-Wei Xu*, Sen-Lin Ji, Huan-Jun Li, Meng-Fei Ren, Yan-Qing Duan, Li-Zhi Dang, Ming-He Mo (2015) Increased polysaccharide production and biosynthetic gene expressions in a submerged culture of Ganoderma lucidum by the overexpression of the homologous alpha-phosphoglucomutase gene. Bioprocess and Biosystems Engineering, 38: 399-405
8. Sen-Lin Ji, Rui Liu, Meng-Fei Ren, Huan-Jun Li,Jun-Wei Xu*(2015) Enhanced production of polysaccharide through the overexpression of the homologous UDP glucose pyrophosphorylase gene in a submerged culture of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher basidiomycetes). International Journal of Medicinal Mushrooms, 17: 435-442
9. Jiang-Sheng Zhou, Sen-Lin Ji, Meng-Fei Ren, Yi-Long He, Xiao-Ran Jing,Jun-Wei Xu*(2014) Enhanced accumulation of individual ganoderic acids in a submerged culture of Ganoderma lucidum by the overexpression of squalene synthase gene. Biochemical Engineering Journal, 90: 178-183
10. Xuya Yu, Sen-Lin Ji, Yi-Long He, Meng-Fei Ren,Jun-Wei Xu*(2014) Development of an expression plasmid and its use in genetic manipulation of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher basidiomycetes). International Journal of Medicinal Mushrooms, 16: 161-168
11. Yan-Qing Duan, Zhan-Chang Xing,Jun-Wei Xu*(2013) Screening of a high yield polysaccharide strain from ten edible and medicinal fungi and optimization of its culture conditions. Research Journal of Biotechnology, 8:11-15
12.Jun-Wei Xu, Yi-Ning Xu, Jian-Jiang Zhong (2012) Enhancement of ganoderic acid accumulation by overexpression of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase gene in the basidiomycete Ganoderma lucidum. Applied and Environmental Microbiology, 78: 7968-7976
13.Jun-Wei Xu, Wei Zhao, Yi-Ning Xu, Jian-Jiang Zhong (2012) Isolation and analysis of differentially expressed genes during asexual sporulation in liquid static culture of Ganoderma lucidum by suppression subtractive hybridization. Molecular Biology Reports, 39: 3603-3610
14.Jun-Wei Xu, Wei Zhao, Jian-Jiang Zhong (2011) Isolation and characterization of a novel Ganoderma lucidum gene that differentially expressed between shaking culture and liquid static culture. Genes & Genomics, 33: 645-651
15.Jun-Wei Xu, Wei Zhao, Jian-Jiang Zhong (2010) Biotechnological production and application of ganoderic acids. Applied Microbiology and Biotechnology, 87: 457-466
16.Jun-Wei Xu, Yi-Ning Xu, Jian-Jiang Zhong (2010) Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. Applied Microbiology and Biotechnology, 85: 941-948
