基本信息
通訊地址: 蘇州高新區(qū)科技城科靈路88號
簡歷
博士畢業(yè)于美國佛羅里達(dá)大學(xué)，佛羅里達(dá)大學(xué)藥學(xué)院 博士后、助理科學(xué)家�，F(xiàn)任本所學(xué)科帶頭人， 研究員， 博士生導(dǎo)師。目前，主持國家自然科學(xué)基金面上項(xiàng)目，省，市項(xiàng)目；參與國家重大傳染病專項(xiàng)課題；并開展一項(xiàng)科研成果產(chǎn)業(yè)化。實(shí)驗(yàn)室的主要研究內(nèi)容有，1，腺相關(guān)病毒（AAV）基因治療；2，基于 腺相關(guān)病毒（AAV）倒置末端重復(fù)序列（ITR）的AAV-ITR單鏈微載體的研發(fā)；3，含有AAVS1位點(diǎn)定點(diǎn)整合外源基因的成人細(xì)胞誘導(dǎo)多能干細(xì)胞。在人類基因治療等國內(nèi)外學(xué)術(shù)刊物上發(fā)表12篇學(xué)術(shù)論文。任國際SCI學(xué)術(shù)刊物Genetic Testing and Molecuar Biomrkers編委。
研究領(lǐng)域
腺相關(guān)病毒（AAV）基因治療
代表論著
1. 2013. 基于AAV-ITR的基因表達(dá)微載體 藥物生物技術(shù) 李泰明，平菡，張春.
2. 2013. 定量重組腺相關(guān)病毒基因組滴度的qPCR新方法 生物工程學(xué)報(bào) 蒙青林，張彬彬，張春.
3. 2013. 基于蛋白質(zhì)反式剪接在大腸桿菌中表達(dá)鱟C因子CES多肽 基因組學(xué)和應(yīng)用生物學(xué) 王影影，劉濤，祁靜，張春，郭玲玲.
4. 2012. Electrochemical investigation of endotoxin induced limulus amebocyte lysate gel-clot process Electrochemistry Communications Peng Miao, Kun Han, Jing Qi, Chun Zhang, Tao Liu.
5. 2007.9 Characterization of a Bipartite rAAV Vector for Site Specific Integration. (此論文被作為當(dāng)月期刊的封面故事刊載). Hum Gene Ther. Zhang C, Cortez N, Berns KI.
6. 2006.11 A gene delivery approach for antimicrobials: _expression of defensins. Journal of Drug Targeting. Zhang C, Yadava P, Sun J, and Hughes JA.
7. 2006.8 In Vitro evidence of Hsc70 functioning as a molecular chaperone during cold stress. Plant Physiol. and Biochem. Zhang C and Guy CL.
8. 2006.5 Antimicrobial activities of human beta-defensins against Bacillus species. Int J Antimicrob Agents. Yadava P, Zhang C, Sun J, Hughes JA.
9. 2006.8 Generation of aberrant forms of DFF40 concurrent with caspase-3 activation during acute and chronic liver injury in rats. Biochem Biophys Res Commun. Xiang Y, Johnson EA, Zhang C, Huang G, Hayes RL, Wang KK, Svetlov SI.
10. 2005.1 Co-immunoprecipitation of hsp100 with hsc70. Plant Physiol. and Biochem. Zhang C and Guy CL.
11. 2004.6 Polyethylenimine strategies for plasmid delivery to brain-derived cells. Methods. Zhang C, Yadava P, and Hughes JA.
12. 2000.2 Diurnal regulation of hsp70 in plant photosynthetic tissue. The Plant J. Li QB, Haskell DW, Zhang C, Sung DY and Guy CL.