基本信息
姓 名: 李曉波
職 務(wù):
職 稱: 副研究員（自然科學(xué)）
簡(jiǎn)歷
李曉波，女，漢族，中共黨員，理學(xué)博士，中國(guó)科學(xué)院新疆理化技術(shù)研究所副研究員，碩士生導(dǎo)師。
主要研究領(lǐng)域
1．化學(xué)遺傳學(xué)方法篩選抗腫瘤先導(dǎo)化合物及抗腫瘤分子機(jī)理研究
化學(xué)遺傳學(xué)(chemical genetics)是一門(mén)應(yīng)用小分子有機(jī)化合物來(lái)系統(tǒng)地干擾和探索細(xì)胞內(nèi)生物學(xué)過(guò)程，從而鑒定參與這些生物過(guò)程的生物大分子的方法。對(duì)新疆特有植物中提取組分，化合物及有機(jī)合成的化合物體外進(jìn)行高通量篩選，獲得高活性的抗腫瘤組分、化合物。結(jié)合流式細(xì)胞技術(shù)，基因芯片，蛋白芯片技術(shù)研究化合物在細(xì)胞內(nèi)的生物靶點(diǎn)及對(duì)細(xì)胞凋亡，細(xì)胞周期相關(guān)的信號(hào)轉(zhuǎn)導(dǎo)途徑的影響。
2. 植物次生代謝研究及棉花纖維發(fā)育分子機(jī)理研究
棉花（彩棉）纖維品質(zhì)主要取決于其纖維沉積特性及微觀結(jié)構(gòu)，而它們均受到纖維素合成及次生代謝合成的影響。該研究組利用關(guān)聯(lián)分析、圖位克隆以及轉(zhuǎn)基因等方法對(duì)彩棉色素合成途徑及次生代謝途徑中的重要基因功能的系統(tǒng)深入研究，闡明影響彩色棉花纖維品質(zhì)的分子調(diào)控網(wǎng)絡(luò)。此項(xiàng)研究將有助于培育多色彩、高品質(zhì)的新品種。
主要論文
1） Li xiaobo, Lu xueying，Xiao xiangwen, Haji Akber Aisa. Anti-proliferative and inhibits expression of VEGF and angiogenesis effects of luteolin in human gastric cancer BGC-823 cell line[J].Mol Pharmacol.(submitted)
2）Xueling Hou, Xiaobo Li, Helimay Hemit, Haji Akber Aisa. Synthesis, characterization and antitumor activities of new palladium (II) complexes with 1-(alkyldithiocarbonyl)-imidazoles. (under viewing)
3) Li xiaobo, Lu xueying，liyanhong. Characterize on gene express chip of luteolin inhibiting gastric cancer. (under viewing)
4）Li xiaobo, Li yanhong, Lu xueying, Dithiocarbamate as anticancer agent: relationship of structure and bioactivities. (under viewing)
6) Li xiaobo, Liang guohua, Zhu lihuang et al. Functional analysis of a semi-dwarf sdg in rice with near isogenic lines. (In English) Progress in natural science
7) Li xiaobo, Xu jichen and Zhu lihuang. Gibberellins signaling transduction and plant dwarfism. Journal of Chinese biotechnology
8) Xu jichen, Li xiaobo, Zhu lihuang. Comparative mapping of rice root traits in seedlings grown in nutrient or non-nutrient solution. (In English) Progress in natural science
9) Xu jichen, Liu guozheng, Li xiazheng, Xiao han, Li xiaobo, Li hongchang, Wei lirong, Zhu lihuang. Characterization and electronic hybridization of a gene encoding UROD in rice. Progress in natural science.
10) Li hongchang, Qian qian, Wang yun, Li xiaobo, Zhu lihuang, Xu jichen. Characterization and mapping of a white panicle mutant gene in rice. Chinese Science Bulletin
11) Li xiaobo and Li zhiping. Separation and analysis of interface-active substances in Karalay crude oil. Oilfield Chemistry