人物履歷
(1956.7-)安徽肥西人,植物分子遺傳學(xué)家,研究員、博
士生導(dǎo)師。
美國(guó)科學(xué)院院士、發(fā)展中國(guó)家科學(xué)院院士、中國(guó)科學(xué)院院士、德國(guó)科學(xué)院院士。
1982年,畢業(yè)于安徽農(nóng)學(xué)院(現(xiàn)安徽農(nóng)業(yè)大學(xué))學(xué)士學(xué)位。
1984年,中國(guó)科學(xué)院遺傳所 碩士學(xué)位。
1985-1991年,獲美國(guó)布蘭代斯(Brandeis)大學(xué) 博士學(xué)位。
1991—1994年,在美國(guó)康乃爾大學(xué)湯普遜(Boyce Thompson)植物研究所進(jìn)行博士后研究工作。
2001年,中國(guó)科學(xué)院院士。
2004年,第三世界科學(xué)院院士。
2011年,美國(guó)科學(xué)院院士。
2012年,德國(guó)科學(xué)院院士。
2011年,獲得美國(guó)植物生物學(xué)家協(xié)會(huì)(American Society of Plant Biologists, ASPB) 終身會(huì)員獎(jiǎng)(Corresponding Membership Award)。
2012年11月14日,當(dāng)選為中共第十八屆中央候補(bǔ)委員。
2013年5月21日,入選歐洲分子生物學(xué)組織(EMBO)外籍成員。
歷任:中國(guó)科學(xué)院遺傳所所長(zhǎng) (1999-2001)
中國(guó)科學(xué)院遺傳與發(fā)育生物學(xué)研究所所長(zhǎng)(2001-2004)。
中國(guó)科學(xué)院副院長(zhǎng)、黨組成員 (2004-2011)
于2007-03受聘為杜邦先鋒顧問(wèn),擔(dān)任農(nóng)業(yè)部副部長(zhǎng)后,杜邦為他補(bǔ)辦了一個(gè)離職報(bào)告,但至12年仍然掛在杜邦公司職員名單上。(2007-2011)
現(xiàn)任:任中華人民共和國(guó)農(nóng)業(yè)部副部長(zhǎng)、中國(guó)農(nóng)業(yè)科學(xué)院院長(zhǎng)(2011-至今)。
兼任:中國(guó)遺傳學(xué)會(huì)七、八屆(2013 截至)理事長(zhǎng)等。
2004年1月,李家洋任中國(guó)科學(xué)院副院長(zhǎng)、黨組成員。
2011年5月3日,美國(guó)國(guó)家科學(xué)院(NAS)院士增選名單揭曉,本次共新增院士90名,其中外籍院士18名。其中李家洋為美國(guó)國(guó)家科學(xué)院外籍院士。
2018年3月,第十三屆全國(guó)人民代表大會(huì)常務(wù)委員會(huì)委員、第十三屆全國(guó)人民代表大會(huì)農(nóng)業(yè)與農(nóng)村委員會(huì)副主任委員。
任免信息
2018年3月18日,第十三屆全國(guó)人民代表大會(huì)第一次會(huì)議,選舉李家洋為第十三屆全國(guó)人民代表大會(huì)常務(wù)委員會(huì)委員。
負(fù)責(zé)工作
李家洋主要從事植物分子遺傳學(xué)研究,他利用模式植物擬南芥與重要糧食作物水稻探索植物生長(zhǎng)發(fā)育的調(diào)控機(jī)理。主要研究工作包括:采用圖位法克隆了水稻分蘗控制基因MOC1,開(kāi)拓了水稻分蘗控制分子機(jī)理研究的新領(lǐng)域;利用水稻脆稈突變體分離了BC1基因,闡述了水稻機(jī)械強(qiáng)度的控制機(jī)理;通過(guò)獲得的擬南芥膽堿生物合成突變體,初步明確了膽堿合成與植物溫度敏感雄性不育性的關(guān)系;通過(guò)圖位克隆法分離出導(dǎo)致細(xì)胞死亡的基因MOD1,明確了初級(jí)代謝途徑的缺陷會(huì)導(dǎo)致植物細(xì)胞凋亡;利用轉(zhuǎn)基因技術(shù),創(chuàng)制出色氨酸與吲哚乙酸合成量改變的轉(zhuǎn)基因植物,從而提出植物生長(zhǎng)素吲哚乙酸生物合成途徑的新模式;建立了一種簡(jiǎn)易的基因芯片體系,鑒定出一批油菜素內(nèi)酯的應(yīng)答基因,并證實(shí)了油菜素內(nèi)酯對(duì)植物細(xì)胞分裂的促進(jìn)作用;發(fā)展了系統(tǒng)鑒定植物功能基因的植物表達(dá)文庫(kù)轉(zhuǎn)化法,分離出一批株型與育性等生長(zhǎng)發(fā)育性狀改變的擬南芥突變體,克隆了相關(guān)的基因。
在李家洋任期大力推廣杜邦先鋒玉米轉(zhuǎn)基因作物。
著作成果
自1999年擔(dān)任遺傳研究所所長(zhǎng)以來(lái),通過(guò)加強(qiáng)與所領(lǐng)導(dǎo)班子成員的團(tuán)結(jié)、積極引進(jìn)和培養(yǎng)優(yōu)秀科研人才、強(qiáng)化規(guī)章制度建設(shè)與行政管理工作的公開(kāi)公平公正、創(chuàng)造出一種寬松和諧與人人奮發(fā)進(jìn)取的科研環(huán)境,促進(jìn)了研究所的迅速發(fā)展。
2004年全球華人生物科學(xué)家大會(huì)生命科學(xué)成就獎(jiǎng),國(guó)家自然科學(xué)獎(jiǎng)二等獎(jiǎng),第三世界科學(xué)院(TWAS)金講演獎(jiǎng)。
第一個(gè)《Annual Review of Plant Biology》(植物生物學(xué)年鑒) 發(fā)表文章中國(guó)本土科學(xué)家。
2003年中國(guó)和世界十大科技進(jìn)展:二、我國(guó)科學(xué)家提示水稻高產(chǎn)的分子奧秘和超級(jí)雜交稻研究取得重大突破。
2010年中國(guó)和世界十大科技進(jìn)展:5、水稻基因育種技術(shù)獲突破性進(jìn)展。
機(jī)理研究
高等植物株型形成是一個(gè)基本的但卻是十分復(fù)雜的生物學(xué)問(wèn)題,涉及到植物特定器官的形成與發(fā)育、生長(zhǎng)調(diào)節(jié)物質(zhì)的合成與作用機(jī)理、基礎(chǔ)代謝產(chǎn)物的合成與利用等方面。我們從上述三個(gè)方面進(jìn)行深入而系統(tǒng)的研究以解析高等植物株型形成的調(diào)控系統(tǒng)。
(1)通過(guò)對(duì)側(cè)芽形成與伸長(zhǎng)突變體的分子遺傳學(xué)分析,重點(diǎn)闡明側(cè)生分生組織形成的起始信號(hào)、側(cè)芽形成的信號(hào)轉(zhuǎn)導(dǎo)途徑、生長(zhǎng)調(diào)節(jié)物質(zhì)對(duì)側(cè)芽伸長(zhǎng)生長(zhǎng)的調(diào)控機(jī)理、側(cè)芽休眠與生長(zhǎng)的分子調(diào)控機(jī)理;
(2)利用分子生物學(xué)方法研究植物生長(zhǎng)素等植物激素的代謝和分子調(diào)控機(jī)理及其在植物株型形成中的作用;
(3)利用實(shí)驗(yàn)室自主發(fā)展的植物表達(dá)文庫(kù)轉(zhuǎn)化法創(chuàng)制植物株型突變體,鑒定和克隆調(diào)控株型形成的基因,闡明基礎(chǔ)代謝途徑對(duì)株型形成的作用機(jī)理。
水稻研究
利用關(guān)聯(lián)分析、圖位克隆以及轉(zhuǎn)基因等方法對(duì)稻米品質(zhì)的調(diào)控基因進(jìn)行系統(tǒng)性研究。在此基礎(chǔ)上,通過(guò)分子輔助育種對(duì)水稻品質(zhì)進(jìn)行改良。
論文介紹
A. Peer-Reviewed Articles
1.Chen L, Xiong G, Cui X, Yan Y, Xu T, Qian Q, Xue Y,Li Jand Wang Y (2013) OsGRAS19 may be a novel component involved in the brassinosteroid signaling pathway in rice.Mol Plantdoi:10.1093/mp/sst027. 2. Zhao L, Zhou X, Wu Z, Yi W, Xu Y, Li S, Xu T, Liu Y, Chen R, Kovach A, Kang Y, Hou L, He Y, Xie C, Song W, Zhong D, Xu Y, Wang Y,Li J, Zhang C, Melcher K, Xu H (2013) Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactonesignaling DWARF14.23:436-439. 3. Zhang X, Wang J, Huang J, Lan H, Wang C, Yin C, Wu Y, Tang H, Qian Q,Li J, and Zhang H (2012) Rare allele of OsPPKL1 associated with grain length causes extra-large grain and a significant yield increase in rice.Proc Natl Acad Sci USA109: 21534-21539. 4. Huang X, Kurata N, Wei X, Wang Z, Wang A, Zhao Q, Zhao Y, Lu H, Li W, Guo Y, Lu Y, Liu K, Zhou C, Fan D, Weng Q, Zhu C, Huang T, Zhang L, Wang Y, Feng L, Furuumi H, Kubo T, Miyabayashi T, Yuan X, Xu Q, Dong G, Zhan Q, Li C, Fujiyama A, Toyoda A, Lu T, Feng Q, Qian Q,Li Jand Han B (2012) A map of rice genome variation reveals the origin of cultivated rice and domestication-associated genes.Nature490: 497-502. 5. Xu C, Wang Y, Yu Y, Duan J, Liao L, Xiong G, Meng X, Liu G,Qian Q andLi J(2012) Degradation of(MOC1) by APC/Cregulates rice tillering.Nature CommunicationsDOI: 10.1038/ncomms1743. 6. Huang X, Zhao Y, Wei X, Li C, Wang A, Zhao Q, Li W, Guo Y, Deng L, Zhu C, Fan D, Lu Y, Weng Q, Liu K, Zhou T, Jing Y, Si L, Dong G, Huang T, Lu T, Feng Q, Qian Q,Li Jand Han B (2012) Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasmNature Genet44: 32-39. 7. Huang Xu, Wei X, Sang T, Zhao Q, Feng Q, Zhao Y, Li C, Zhu C, Lu T, Zhang Z, Li M, Fan D, Guo Y, Wang A, Wang L, Deng L, Li W, Lu Y, Weng Q, Liu K, Huang T, Zhou T, Jing Y, Li W, Lin Z, Bucker ES, Qian Q, Zhang Q,LiJ and Han B (2010) Genome-wide association studies of 14 agronomic traits in rice landraces.Nature Genet42: 961-967. 8. Tian Z, Yan C, Qian Q, Yan S, Xie H, Wang F, Xu J, Liu G, Wang Y, Liu Q, Tang S,Li Jand Gu M (2010) Development of gene-tagged molecular markers for starch synthesis-related genes in rice.Chin Sci Bull55: 3768-3777. 9. Zhang M, Zhang B, Qian Q, Yu Y, Li R, Zhang J, Liu X, Zeng D,Li Jand Zhou Y (2010) Brittle Culm12, a dual-targeting Kinesin-4 protein, controls cell cycle progression and wall properties in rice.Plant J63: 312-328. 10. Jiao Y, Wang Y, Xue D, Wang J, Yan M, Liu G, Dong G, Zeng D, Lu Z, Zhu X, Qian Q andLi J(2010) Regulation ofby OsmiR156 defines ideal plant architecture in rice.Nature Genet42, 541-544. 11. Cui X, Ge C, Wang R, Wang H, Chen W, Fu Z, Jiang X,Li J, Wang Y (2010) Themutation affects plant architecture through altering response to cytokinin and auxin in.Cell Res20: 576-586. 12. Melcher K, Ng LM, Zhou X, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y,Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu J, and Xu E (2009). A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors.Nature462: 602-608. 13. Wang H, Zhu Y, Fujioka S, Asami T,Li J, and Li J (2009). Regulation ofbrassinosteroid signaling by atypical basic helix-loop-helix proteins.Plant Cell21: 3781-3791. 14. Lin H, Wang R, Qian Q, Yan M, Meng X, Fu Z, Yan C, Jiang B, Su Z,Li J, and Wang Y (2009). DWARF27, an iron-containing protein required for the biosynthesis of strigolactones, regulates rice tiller bud outgrowth.Plant Cell21: 1512-1525. 15. Huang X, Qian Q, Liu Z, Sun H, He S, Luo D, Xia G, Chu C,Li J, and Fu X. (2009) Natural variation at thelocus enhances grain yield in rice.Nat Genet41: 494-497. 16. Li S, Qian Q, Fu Z, Zeng D, Meng X,Kyozuka J,Maekawa M,Zhu X, Zhang J,Li Jand Wang Y (2009)encodes a putative PTR transporter and determines rice panicle size.Plant J58: 592-605 17. Zhou Y, Li S, Qian Q, Zeng D, Zhang M, Guo L, Liu XL, Zhang B, Deng L, Liu XF, Luo G, Wang X andLi J(2009) BC10, a DUF266-containing and golgi-located type II membrane protein, is required for cell wall biosynthesis in rice (L.)Plant J57: 446-462. 18. Tian Z, Qian Q, Liu Q, Yan M, Liu X, Yan C, Liu G, Gao Z, Tang S, Zeng D, Wang Y, Yu J, Gu M andLi J(2009) Allelic diversities in rice starch biosynthesis lead to a diverse array of rice eating and cooking qualities.Proc Natl Acad Sci USA106: 21760u201321765. 19. Yu Y, Tang T, Qian Q, Wang Y, Yan M, Zeng D, Han B, Wu Chung-I, Shi S and Li J (2008) Independent losses of function in a polyphenol oxidase in rice: differentiation in grain discoloration between subspecies and the role of positive selection under domestication.Plant Cell20: 2946-2959. 20. Xu W, Huang J, Li B,Li Jand Wang Y (2008) Is kinase activity essential for biological functions of BRI1?Cell Res18: 472-478. 21. Li P, Wang Y, Qian Q, Fu Z, Wang M, Zeng D, Li B, Wang X, andLi J ((2007)controls rice shoot gravitropism through regulating polar auxin transport.Cell Res17: 402-410. 22. Zhang X, Dai Y, Xiong Y, DeFraia C,Li J, Dong X, and Mou Z (2007) Overexpression ofleads to activation of plant basal and systemic acquired resistance.Plant J52: 1066-1079. 23. Dai Y, Wang H, Li B, Huang J, Liu X, Zhou Y, Mou Z andLi J(2006) Increased expression ofcauses deficiency in polar auxin transport and leads to plant architectural abnormality inPlant Cell18: 308-320. 24. Xiong G, Hu X, Jiao Y, Yu Y, Chu C,Li J, Qian Q and Wang Y (2006), which encodes a putative RNA-binding protein, regulates shoot development of rice.Cell Res16: 267-276. 25. Ge C, Cui X, Wang Y, Hu Y, Fu Z, Zhang D, Cheng Z, andLi J(2006), encoding an S-adenosylmethionine decarboxylase, is required forgrowth and development.Cell Res16: 446-456. 26. Gong W, Shen Y, Ma L, Pan Y, Du Y, Wang D, Yang J, Hu L, Liu X, Dong C, Ma L, Chen Y, Yang X, Gao Y, Zhu D, Tan X, Mu J, Zhang D, Liu Y, Dinesh-Kumar SP, Li Y, Wang X, Gu H, Qu L, Bai S, Lu Y,Li J, Zhao J, Zuo J, Huang H, Deng X, and Zhu Y (2004) Genome-wide ORFeome cloning and analysis oftranscription factor genes.Plant Physiol135: 773u2013782. 27. Tian C, Wan P, Sun S,Li Jand Chen M (2004) Genome-wide analysis of the GRAS gene family in rice andPlant Mol Biol54: 519-532. 28. Hu Y, Wang Y, Liu X,Li J(2004)RAV1 is down-regulated by brassinosteroid and may act as a negative regulator during plant development.Cell Res14: 8-15. 29. Li Y, Qian Q, Zhou Y, Yan M, Sun L, Zhang M, Fu Z, Wang Y, Han B, Pang X, Chen M andLi J(2003)which encodes a COBRA-like protein, affects the mechanical properties of rice plants.Plant Cell15: 2020-2031. 30. Li X, Qian Q, Fu Z, Wang Y, Xiong G, Zeng D, Wang X, Liu X, Teng S, Hiroshi F, Yuan M, Luo D, Han B andLi J(2003) Control of tillering in rice.Nature422: 618-621. 31. Feng Q, Zhang Y, Hao P, Wang S, Fu G, Huang Y, Li Y, Zhu J, Liu Y, Hu X, Jia P, Zhang Y, Zhao Q, Ying K, Yu S, Tang Y, Weng Q, Zhang L, Lu Y, Mu J, Lu Y, Zhang LS, Yu Z, Fan D, Liu X, Lu T, Li C, Wu Y, Sun T, Lei H, Li T, Hu H, Guan J, Wu M, Zhang R, Zhou B, Chen Z, Chen L, Jin Z, Wang R, Yin H, Cai Z, Ren S, Lv G, Gu W, Zhu G, Tu Y, Jia J, Zhang Y, Chen J, Kang H, Chen X, Shao C, Sun Y, Hu Q, Zhang X, Zhang W, Wang L, Ding C, Sheng H, Gu J, Chen S, Ni L, Zhu F, Chen W, Lan L, Lai Y, Cheng Z, Gu M, Jiang J,Li J, Hong G, Xue Y and Han B (2002) Sequence and analysis of rice chromosome 4.Nature420: 316-320. 32. Mou Z, Wang X, Fu Z, Dai Y, Han C, Ouyang J, Bao F, Hu Y, andLi J(2002) Silencing of phosphoethanolamine-methyltransferase results in temperature-sensitive male sterility and salt hypersensitivity in.Plant Cell14: 2031-2043. 33. Hu Y, Bao F andLi J(2000) The promotive effect of brassinosteroids on cell division involves a distinct-induction pathway in.Plant J24: 693-701. 34. Ouyang J, Shao X andLi J(2000) Indole-3-glycerol phosphate, a branchpoint of indole-3-acetic acid biosynthesis from tryptophan biosynthetic pathway in.Plant J24: 327-333. 35. Mou Z, He Y, Dai Y, Liu X andLi J(2000) Deficiency in fatty acid synthase leads to premature cell death and dramatic alterations in plant morphology.Plant Cell12: 405-417. B.Invited Articles 1.LiJand Chua N-H (2011) A comprehensive understanding of plant growth and development.Curr Opin Plant Biol14: 1-3. 2. Wang Y andLi J(2011) Branching in rice.Curr Opin Plant Biol14: 94-99. 3. Wang Y andLi J(2008). Rice, rising.Nat Genet40,1273-1275. 4. Wang Y andLi J(2008). Molecular basis of plant architecture.Annu Rev Plant Biol59: 253-279. 5. Zhang Q,Li J, Xue Y, Han B and Deng X (2008) Rice 2020: A call for an international coordinated effort in rice functional genomics.Mol Plant1: 1-15. 6. Han B, Xue Y,Li J, Deng X, and Zhang Q (2007) Rice functional genomics research in China.Phil Trans R Soc B362: 1009u2013102. 7. Wang Y andLi J(2006) Genes controlling plant architecture.Curr Opin Biotech17: 123-129. 8. Xu Z andLi J(2006) Plant hormones research in China: past, present and future.Chin Bull Bot23: 433-442. 9. Wang Y, Xue Y andLi J(2005) Towards molecular breeding and improvement of rice in China.Trends Plant Sci10: 610-614. 10. Xue Y,Li J, and Xu Z (2004) Recent highlights of the China Rice Functional Genomics Program.Trends Genet19: 390-394. C. Invited Book Chapter 1. Wang Y andLi J(2012) Regulation of plant architecture. InPlant Physiology and Molecular Biology(Chen X, Xue H, eds), Higher Education Press, Beijing, pp. 418-432. 2. Wang Y, Chen M andLi J(2007) Rice. InVol. 59 Transgenic Crops IV (E.C. Pua and M.R.Davey, eds), Springer-Verlag Berlin Heidelberg, pp. 35-54.
榮譽(yù)記錄
2018年5月,獲得2018年度陳嘉庚科學(xué)獎(jiǎng)。