人物經(jīng)歷
1993年于武漢大學(xué)獲化學(xué)專業(yè)和細(xì)胞生物學(xué)專業(yè)學(xué)士學(xué)位；
1999年1月于武漢大學(xué)獲高分子化學(xué)和物理專業(yè)博士學(xué)位；
1994年在北京大學(xué)醫(yī)學(xué)部（原北京醫(yī)科大學(xué)）藥學(xué)院天然與仿生藥物國家重點(diǎn)實(shí)驗(yàn)室從事高分子免疫佐劑的開放課題研究；
1999年5月至2004年6月先后在約翰霍普金斯醫(yī)學(xué)院新加坡生命醫(yī)學(xué)中心（Johns Hopkins Singapore）、美國約翰霍普金斯大學(xué)醫(yī)學(xué)院生物醫(yī)學(xué)工程系從事博士后研究；
2004年9月，入選中國科學(xué)院“百人計(jì)劃—引進(jìn)國外杰出人才”，任中國科學(xué)技術(shù)大學(xué)高分子科學(xué)與工程系教授，博士生導(dǎo)師，
2006年獲“百人計(jì)劃”擇優(yōu)支持；
2006年7至8月，德國羅斯托克大學(xué)醫(yī)學(xué)院訪問教授；
2006年12月起任中國科學(xué)技術(shù)大學(xué)生命科學(xué)學(xué)院教授、博士生導(dǎo)師，合肥微尺度物質(zhì)科學(xué)國家實(shí)驗(yàn)室研究員；
2011年獲國家杰出青年科學(xué)基金資助。
任中國生物材料協(xié)會理事、中國化學(xué)會化學(xué)生物學(xué)專業(yè)委員會委員、中國微納協(xié)會納米生物與醫(yī)藥技術(shù)專業(yè)委員會委員，Biomaterials Science雜志（英國皇家化學(xué)會）編委；
在Science Translational Medicine、Angew Chem Int Ed、J Am Chem Soc、Advanced Materials、ACS Nano、J Controlled Release、Biomaterials等雜志發(fā)表研究論文90余篇，參與撰寫英文專著章節(jié)三篇，論文被引用2500余次；授權(quán)中國發(fā)明專利5項(xiàng)，美國發(fā)明專利1項(xiàng)，獲得2012年教育部自然科學(xué)獎(jiǎng)一等獎(jiǎng)（第二單位）。
研究方向
1.生物醫(yī)用高分子材料；
2·蛋白質(zhì)和核酸的高分子傳遞體系；
3·基因治療和組織工程。
腫瘤靶向治療和腫瘤干細(xì)胞研究、納米藥物和藥物輸送系統(tǒng)、RNA干擾、納米生物材料
主要貢獻(xiàn)
研究課題
1·聚磷酸酯高分子生物材料的合成方法學(xué)及性能評價(jià)；
2·生物可降解納米材料的制備及其細(xì)胞轉(zhuǎn)運(yùn)調(diào)節(jié)和機(jī)制；
3·可注射生物可降解高分子水凝膠的制備及生物醫(yī)用；
4·藥物控制釋放及靶向輸送載體的構(gòu)建及生物學(xué)功效；
5·RNA干擾及siRNA藥物靶向輸送及關(guān)鍵技術(shù)；
6·癌癥基因治療新型傳輸載體、細(xì)胞轉(zhuǎn)運(yùn)機(jī)制及功效；
7·組織工程“人工骨”支架材料及組織工程新方法。
承擔(dān)科技部“973”項(xiàng)目子課題；國家自然科學(xué)基金委杰出青年科學(xué)基金；教育部博士點(diǎn)優(yōu)先支持領(lǐng)域課題；科技部“863”課題；“重大新藥創(chuàng)制”科技重大專項(xiàng)課題等。
研究獲獎(jiǎng)
2001 Controlled Release Society-Capsugel Award on Innovative Aspects of Gastrointestinal Drug Absorption and Delivery, Controlled Release Society
論文專著
1. Xiao CS, Wang YC, Du JZ, Chen XS, Wang J*, Kinetics andMechanism of 2-Ethoxy-2-oxo-1,3,2-dioxaphospholane Polymerization Initiated by Stannous Octoate, MACROMOLECULES 2006, in press
2. Du JZ, Chen DP, Wang YC, Xiao CS, Lu YJ, Wang J*, Zhang GZ, Synthesis and Micellization of Amphiphilic Brush-Coil Block Copolymer Based on Poly(ε-caprolactone) and PEGylated Polyphosphoester, BIOMACROMOLECULES 2006, 7(6): 1898-1963
3. Chen DP, Wang J*, Synthesis and characterization of block copolymer of polyphosphoester and poly(epsilon-caprolactone), MACROMOLECULES 2006, 39 (2): 473-475
4. Li Q, Wang J, Shahani S, Sun DDN, Sharma B, Elisseeff JH, Leong KW, Biodegradable and photocrosslinkable polyphosphoester hydrogel, BIOMATERIALS 2006, 27 (7): 1027-1034
5. Zou JH, Shi WF, Wang J, Jun B, Encapsulation and controlled release of a hydrophobic drug using a novel nanoparticle-forming hyperbranched polyester, MACROMOLECULAR BIOSCIENCE 2005, 5 (7): 662-668
6. Zhang PC, Wang J, Leong KW, Mao HQ, Ternary complexes comprising polyphosphoramidate gene carriers with different types of charge groups improve transfection efficiency, BIOMACROMOLECULES 2005, 6 (1): 54-60
7. Wan ACA, Mao HQ, Wang S, Phua SH, Lee GP, Pan JS, Lu S, Wang J, Leong KW, Poly(phosphoester) ionomers as tissue-engineering scaffolds, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 2004, 70B (1): 91-102
8. Wang J, Lee IL, Lim WS, Chia SM, Yu H, Leong KW, Mao HQ, Evaluation of collagen and methylated collagen as gene carriers, INTERNATIONAL JOURNAL OF PHARMACEUTICS 2004, 279 (1-2): 115-126
9. Wang J, Gao SJ, Zhang PC, Wang S, Mao MQ, Leong KW, Polyphosphoramidate gene carriers: effect of charge group on gene transfer efficiency, GENE THERAPY 2004, 11 (12): 1001-1010
10. Huang SW, Wang J, Zhang PC, Mao HQ, Zhuo RX, Leong KW, Water-soluble and nonionic polyphosphoester: Synthesis, degradation, biocompatibility and enhancement of gene expression in mouse muscle, BIOMACROMOLECULES 2004, 5 (2): 306-311
11. Wang J, Sun DDN, Shin-ya Y, Leong KW, Stimuli-responsive hydrogel based on poly(propylene phosphate), MACROMOLECULES 2004, 37 (2): 670-672
12. Li Q, Williams CG, Sun DDN, Wang J, Leong K, Elisseeff JH, Photocrosslinkable polysaccharides based on chondroitin sulfate, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH 2004, 68A (1): 28-33
13. Li Y, Wang J, Lee CGL, Wang CY, Gao SJ, Tang GP, Ma YX, Yu H, Mao HQ, Leong KW, Wang S, CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexes, GENE THERAPY 2004, 11 (1): 109-114
14. Lu HF, Lim WS, Wang J, Tang ZQ, Zhang PC, Leong KW, Chia SM, Yu H, Mao HQ, Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance, BIOMATERIALS 2003, 24 (27): 4893-4903
15. Wang J, Huang SW, Zhang PC, Mao HQ, Leong KW, Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoesters, INTERNATIONAL JOURNAL OF PHARMACEUTICS 2003, 265 (1-2): 75-84
16. Fang N, Wang J, Mao HQ, Leong KW, Chan V, BHEM-Chol/DOPE liposome induced perturbation of phospholipid bilayer, COLLOIDS AND SURFACES B-BIOINTERFACES 2003, 29 (4): 233-245
17. Zhao Z, Wang J, Mao HQ, Leong KW, Polyphosphoesters in drug and gene delivery ADVANCED DRUG DELIVERY REVIEWS 2003, 55 (4): 483-499
18. Wang J, Zhang PC, Lu HF, Ma N, Wang S, Mao HQ, Leong KW, New polyphosphoramidate with a spermidine side chain as a gene carrier, JOURNAL OF CONTROLLED RELEASE 2002, 83 (1): 157-168
19. Wang J, Zhang PC, Mao HQ, Leong KW, Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier, GENE THERAPY 2002, 9 (18): 1254-1261
20. Wang J, Mao HQ, Leong KW, A novel biodegradable gene carrier based on polyphosphoester, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2001, 123 (38): 9480-9481
