人物經(jīng)歷
1982年畢業(yè)于西北農(nóng)業(yè)大學(xué),獲學(xué)士學(xué)位;1985年獲碩士學(xué)位,同年留校任教至今;1993年獲博士學(xué)位;曾于2006年在加拿大蒙特利爾大學(xué)醫(yī)學(xué)院進(jìn)行高級(jí)訪問研究。
曾先后擔(dān)任西北農(nóng)業(yè)大學(xué)動(dòng)物科學(xué)系副主任、主任,動(dòng)物科學(xué)與動(dòng)物醫(yī)學(xué)學(xué)院院長(zhǎng),西北農(nóng)林科技大學(xué)畜牧獸醫(yī)學(xué)院院長(zhǎng)、動(dòng)物科技學(xué)院院長(zhǎng)。2001年獲全國(guó)師德先進(jìn)個(gè)人稱號(hào)。
社會(huì)職務(wù)
先后擔(dān)任陜西省第九屆人大代表,政協(xié)陜西省第九屆常委和陜西省決策咨詢委員會(huì)委員和第十一屆全國(guó)政協(xié)委員等職務(wù)。
學(xué)術(shù)兼職
國(guó)家973計(jì)劃農(nóng)業(yè)科學(xué)領(lǐng)域?qū)<易稍兘M成員、國(guó)家轉(zhuǎn)基因豬新品種培育重大專項(xiàng)執(zhí)行專家組成員、國(guó)家生豬遺傳改良計(jì)劃專家組成員、國(guó)家畜禽遺傳資源委員會(huì)豬專業(yè)委員會(huì)委員、國(guó)家生豬產(chǎn)業(yè)技術(shù)體系崗位科學(xué)家、中國(guó)畜牧獸醫(yī)學(xué)會(huì)動(dòng)物遺傳育種分會(huì)常務(wù)理事、中國(guó)畜牧獸醫(yī)學(xué)會(huì)養(yǎng)豬學(xué)分會(huì)副理事長(zhǎng)、西北五。▍^(qū))養(yǎng)豬協(xié)會(huì)理事長(zhǎng)、《中國(guó)生物化學(xué)與分子生物學(xué)報(bào)》和《中國(guó)細(xì)胞生物學(xué)學(xué)報(bào)》編委等職務(wù)。
研究方向
脂肪沉積的細(xì)胞分子機(jī)理
肌細(xì)胞發(fā)育與肌纖維分化的分子調(diào)控
豬遺傳改良
開設(shè)課程
承擔(dān)本科生《豬生產(chǎn)學(xué)》和研究生《現(xiàn)代生物技術(shù)研究專題》等課程的講授。
學(xué)術(shù)成果
先后主持國(guó)家科技重大專項(xiàng)、國(guó)家973、國(guó)家863、國(guó)家科技支撐計(jì)劃、國(guó)家自然科學(xué)基金、農(nóng)業(yè)部現(xiàn)代農(nóng)業(yè)產(chǎn)業(yè)技術(shù)體系和陜西省重大科技創(chuàng)新專項(xiàng)等課題20余項(xiàng)。迄今共發(fā)表論文160余篇,其中SCI論文80余篇。培養(yǎng)博碩士研究生80余人,其中1人入選國(guó)家青年人才項(xiàng)目專家、1人入選中科院百人計(jì)劃、1人獲全國(guó)百篇優(yōu)秀博士學(xué)位論文獎(jiǎng)。主編《豬生產(chǎn)學(xué)》(面向21世紀(jì)全國(guó)統(tǒng)編教材)和《肉類學(xué)》等多部學(xué)術(shù)著作。獲陜西省科技進(jìn)步一等獎(jiǎng)一項(xiàng)、二等獎(jiǎng)兩項(xiàng)。
代表性論文
[1] Mi L, Zhao XY, Li SM, Yang GS*, Lin JD*. Conserved Function of the Long Noncoding RNA Blnc1 in Brown Adipocyte Differentiation. Molecular Metabolism 2016 ( accepted ). (IF="5.363).
[2] Yang H, Wu JW, Wang SP, Severi I, Sartini L, Frizzell N, Cinti S, Yang GS*, Mitchell GA*. Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis and Insulin Resistance. Diabetes 2016, 65(11): 3396-3409. (IF="8.784).
[3] Wang GQ, Wang Y, Xiong Y, Chen XC, Ma ML, Cai R, Gao Y, Sun YM, Yang GS, Pang WJ*. Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a. Scientific Reports, 2016, 6, srep21865: 1u201313 (IF="5.578).
[4] Zhao CZ,Chen XC,Wu WJ, Pang WJ , Yang GS*. MAT2B promotes adipogenesis by modulating SAMe levels and activating AKT/ERK pathway during porcine intramuscular preadipocyte differentiation. Experimental cell research. 2016, 344(1):11-21 (IF: 3.246)
[5] Zhu JY, Shi XE, Lu HZ, Xia B, Li YF, Li X, Zhang QL, Yang GS*. RNA-seq transcriptome analysis of extensor digitorum longus and soleus muscles in large white pigs. Molecular Genetics and Genomics, 2016, 291(2):11-21 (IF="2.728)
[6] Mi L, Chen YS, Zheng XL, Li YL, Zhang QL, Mo DL, Yang GS*. MicroRNA-139-5p suppresses 3T3u2010L1 preadipocyte differentiation through notch and IRS1/PI3K/Akt insulin signaling pathways. Journal of Cellular Biochemistry, 2015, 116(7): 1195-1204 (IF: 3.263)
[7] Lu H, Shi X, Wu G, Zhu J, Song C, Zhang Q, & Yang GS*. FGF13 regulates proliferation and differentiation of skeletal muscle by downu2010regulating Spry1. Cell proliferation. 2015, 48(5):550u2013560 (IF:3.116)
[8] Cheng J, Li Y., Wu G, Zheng J, Lu H, & Yang GS* . Ectopic expression of RBP4 impairs the insulin pathway and inguinal fat deposition in mice. Journal of physiology and biochemistry, 2014,70(2), 479-486.( IF:2.496)
[9] Ji HL, Song CC, Li YF, He JJ, Li YL, Zheng XL, & Yang GS * . miR-125a inhibits porcine preadipocytes differentiation by targeting ERRα. Molecular and cellular biochemistry, 2014, 395(1-2), 155-165. (IF: 2.388)
[10] Zhang ZY, Mai Y, Yang H, Dong PY, Zheng X L, & Yang GS *. CTSB promotes porcine preadipocytes differentiation by degrading fibronectin and attenuating the Wnt/β-catenin signaling pathway. Molecular and cellular biochemistry, 2014, 395(1), 53-64 (IF: 2.388)
[11] Du B, Cawthorn W P, Su A, Doucette CR, Yao Y, Hemati N, Kampert S McCoin C, Broome DT, Rosen CJ, Yang GS*, MacDougald O. The transcription factor paired-related homeobox 1 (prrx1) inhibits adipogenesis by activating transforming growth factor-β (tgfβ) signaling. Journal of Biological Chemistry, 2013, 288 (5): 3036-3047 (IF: 4.600)
[12]Yang Y, Tarabra E, Yang GS *. Vaitheesvaran B, Palacios G, & Kurland I J. Alteration of de novo glucose production contributes to fasting hypoglycaemia in fyn deficient mice. Plos One, 2013,8(11) e81866. (IF:3.73)
[13] Luo X, Hutley LJ, Webster JA, Kim YH, Liu DF, Newell FS, Widberg CH, Bachmann A, Turner A, Carsten S, Prins JB, Yang GS*, Whitehead JP. Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors. Diabetes, 2012, 61(1): 124-136 (IF: 7.895)
[14] Wu JW, Wang SP, Alvarez F, Casavant S, Gauthier N, Abed L, Soni KG, Yang GS*, Mitchell G A. Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis. Hepatology, 2011, 54(1): 122-132 (IF 11.665)
[15] Bai L, Jia Y, Viswakarma N, Huang J, Vluggens A, Wolins NE, Jafari N, Sambasiva RM, Borensztagn J, Yang GS*, Reddy JK. Transcription coactivator mediator subunit MED1 is required for the development of fatty liver in the mouse. Hepatology, 2011, 53(4): 1164-1174 (IF: 11.665)
[16] Li GX, Li YJ, Li XJ, Ning XM, Li MH, Yang GS*. MicroRNA identity and abundance in developing swine adipose tissue as determined by Solexa sequencing. Journal of Cellular Biochemistry. 2011, 112(5):1318-28. (IF 3.122)