研究方向
(1) 核小體重排和染色質(zhì)結(jié)構(gòu)變化對果蠅胚胎發(fā)育的影響
(2) 核小體排列分布及其在基因調(diào)控中的作用
(3) 組蛋白修飾在核小體重排中的作用機理
(4) 核小體定位序列的識別，DNA序列變化對染色質(zhì)結(jié)構(gòu)的影響
(5) 分子進化學(xué)
人物經(jīng)歷
1995 年畢業(yè)于天津南開大學(xué)，獲學(xué)士學(xué)位。1998年畢業(yè)于天津南開大學(xué)，獲碩士學(xué)位。2004年畢業(yè)于美國愛荷華州州立大學(xué)，獲遺傳學(xué)博士學(xué)位，并輔修生物信 息學(xué)和計算機科學(xué)。畢業(yè)后先后在美國冷泉港實驗室、弗吉尼亞聯(lián)邦大學(xué)、賓夕法尼亞州州立大學(xué)進行博士后研究。2009年應(yīng)聘為同濟大學(xué)特聘教授。
代表文章
1. Jiang, C and Pugh BF. (2009) A compiled and systematic reference map of nucleosome positions across the Saccharomyces genome. Genome Biology, 10:R109
2. Koerber RT, Rhee HS, Jiang C, Pugh BF. (2009) Interaction of transcriptional regulators with specific nucleosomes across the Saccharomyces genome. Mol Cell.35(6):889-902
3. Jiang, C and Pugh BF. (2009) Nucleosome positioning and gene regulation: advances through genomics. Nature Reviews Genetics, 10(3):161-72 Cover Story
4. Mavrich TN, Jiang C(Co-first author), Ioshikhes IP, Li X, Venters BJ, Zanton SJ, Tomsho LP, Qi J, Glaser RL, Schuster SC, Gilmour DS, Albert I, Pugh BF. (2008) Nucleosome organization in the Drosophila genome. Nature, 453(7193):358-62 Article
5. Mavrich, TN, Ioshikhes, IP, Venters, BJ, Jiang, C, Tomsho, LP, Qi, J, Schuster, SC, Albert, I, and Pugh, BF (2008) A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome. Genome Research, 18(7):1073-83
6. Albert I, Wachi S, Jiang C, Pugh BF. (2008) GeneTrack - a genomic data processing and visualization framework. Bioinformatics. 24(10):1305-6
7. Lee C, Li X, Hechmer A, Eisen M, Biggin MD, Venters BJ, Jiang C, Li J, Pugh BF, Gilmour DS. (2008) NELF and GAGA factor are linked to promoter proximal pausing at many genes in Drosophila. Mol Cell Biol.28(10):3290-300
8. Kuo PH, Kalsi G, Prescott CA, Hodgkinson CA, Goldman D, van den Oord EJ, Alexander J, Jiang C, Sullivan PF, Patterson DG, Walsh D, Kendler KS, Riley BP. (2008) Association of ADH and ALDH Genes with Alcohol Dependence in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) Sample. Alcoholism: Clinical and Experimental Research. 32(5):785-95
9. Zhao, Z and Jiang, C (2007) Methylation-Dependent Transition Rates Are Dependent on Local Sequence Lengths and Genomic Regions. Mol Biol Evol.,24(1):23-5
10. Jiang, C, Han, L, Su, B, Li, WH and Zhao, Z (2007) Features and Trend of Loss of Promoter-Associated CpG Islands in the Human and Mouse Genomes. Mol Biol Evol.24(9):1991-2000
11. Jiang, C, Xuan, Z, Zhao, F, and Zhang, MQ (2007) TRED: a Transcriptional Regulatory Element Database, new entries and other development. Nucleic Acids Res.,35: D137-D140
12. Seo, D, Jiang, C and Zhao, Z (2006) A novel statistical method to estimate the effective SNP size in vertebrate genomes and categorized genomic regions. BMC Genomics,7(1):329
13. Boddu, J, Jiang, C, Sangar, V, Olson, T, Peterson, T, and Chopra, S (2006) Comparative structural and functional characterization of sorghum and maize duplications containing orthologous Myb transcription regulators of 3-deoxyflavonoid biosynthesis. Plant Molecular Biology, 60(2):185-99
14. Jiang, C and Zhao, Z (2006) Directionality of point mutation and 5-methylcytosine deamination rates in the chimpanzee genome. BMC Genomics,7(1):316
15. Jiang, C and Zhao, Z (2006) Mutational spectrum in the recent human genome inferred by single nucleotide polymorphisms. Genomics,88(5):527-34
16. Jiang, C, Gu, X, and Peterson, T (2004) Identification of conserved gene structures and carboxy-terminal motifs in the Myb gene family of Arabidopsis and Oryza sativa L. ssp. indica. Genome Biology, 5(7): R46
17. Jiang, C, Gu, J, Chopra , S, Gu, X, and Peterson, T (2004) Ordered Origin of the Typical Two- and Three-Repeat Myb Genes. Gene, 326: 13-22
18. Jiang, C, Song, WQ, Li, XL, and Chen, RY (1998) Studies on microdissection and microcloning of the rye chromosome 1R. Acta Botanica Sinica, 40(11): 988-993
