孫長凱 - 簡介
孫長凱，男，1963年5月出生，上海第二軍醫(yī)大學軍醫(yī)系81級，西安第四軍醫(yī)大學臨床神經(jīng)病學碩士與醫(yī)學博士，北京軍事醫(yī)學科學院博士后，美國Cleveland Clinic神經(jīng)科學系神經(jīng)炎癥實驗室訪問科學家，生物醫(yī)學工程系神經(jīng)生理學實驗室高級訪問學者，神經(jīng)病學研究所癲癇中心客座教授。
孫長凱，現(xiàn)為大連醫(yī)科大學中青年學科帶頭人，神經(jīng)病學主任醫(yī)師、教授，腦疾病研究所所長，遼寧省腦疾病重點實驗室暨遼寧省高校省級腦疾病研究重點實驗室主任，博士生導師，博士后合作導師，大連醫(yī)科大學科技處處長，學科建設(shè)辦公室副主任。
孫長凱 - 成就與貢獻
主要從事癲癇等重大腦疾病防治研究。建立解放軍大連210醫(yī)院神經(jīng)心理學診療室、大連醫(yī)科大學腦疾病研究所、遼寧省高校省級腦疾病研究重點實驗室及遼寧省腦疾病重點實驗室。承擔各類基金課題20余項。1992年開始興奮毒性腦損害中的活性氮介質(zhì)機制研究，提出“一氧化氮-星形膠質(zhì)細胞抗興奮毒性腦損害”新的級聯(lián)機制，揭示了L-精氨酸/一氧化氮介質(zhì)抗興奮毒性的腦保護作用。1997年提出“癲癇及其相關(guān)、相似腦疾病免疫防治的創(chuàng)新性研究”構(gòu)想，提出“神經(jīng)疫苗”概念及其第一個“神經(jīng)疫苗”研究課題。2000年開始研制銀杏葉提取物納米制劑并應(yīng)用于興奮毒性腦損害的防治。2003年4月提出“SARS膽堿能急救療法”，受到衛(wèi)生部專家組肯定。發(fā)表論文百余篇，部分內(nèi)容被收入1996年P(guān)ortland出版社出版的Biology of Nitric Oxide叢書（第5輯），應(yīng)邀在第22屆世界癲癇大會上做15分鐘口頭報告（1997，都柏林），參與組織和主持了全國第一次一氧化氮生物醫(yī)學研究與應(yīng)用學術(shù)會議（1997年），參編（責任編委/編委）著作/教材8部（包括中國科技大學研究生教材及全國研究生規(guī)劃教材），獲遼寧省科技進步一等獎一項，軍隊科技進步二、三、四等獎各一項，武裝警察部隊科技進步二等獎一項。2001年提出開設(shè)碩/博士研究生及七/八年制學生新課程《“臨床神經(jīng)生物學”》，獲遼寧省第五屆高等教育教學成果三等獎，2005年國家級繼續(xù)教育項目12學分。2002年提出“科技工作和科技管理工作的6P目標與指標”。主要學術(shù)與社會兼職：中國機械工程學會高級會員與生物制造工程分會第一屆專業(yè)委員會委員，第21屆中國生理學會神經(jīng)科學專業(yè)委員會委員，《中華醫(yī)學雜志》、《中華神經(jīng)科雜志》等雜志編委，遼寧省藥學會第八屆生化與生物技術(shù)藥物專業(yè)委員會副主任委員，遼寧省生物技術(shù)協(xié)會第三屆理事會常務(wù)理事兼副秘書長，中華醫(yī)學會遼寧省醫(yī)學會第五屆理事會常務(wù)理事，遼寧省生理學會第六屆理事會常務(wù)理事，遼寧省經(jīng)濟體制改革研究會理事會常務(wù)理事，大連市學術(shù)著作出版基金暨著作獎評審委員會醫(yī)學組副組長，中華醫(yī)學會大連市分會生理學�？品謺魅挝瘑T。曾任解放軍大連210醫(yī)院神經(jīng)科副主任，中國人民解放軍自由基生物醫(yī)學專業(yè)委員會副主任委員，沈陽軍區(qū)神經(jīng)病學專業(yè)組副組長，大連醫(yī)科大學基礎(chǔ)醫(yī)學院生理學教研室主任。主要稱號與榮譽：遼寧省百千萬人才工程百人層次人選，遼寧省優(yōu)秀科技工作者，中國管理科學杰出研究者，國務(wù)院特殊津貼專家，大連市市級優(yōu)秀專家。
孫長凱 - 代表性論文
1. Li J, Ma X, Li F, Wang J, Chen H, Wang G, Lv X, Sun CK(Corresponding Author), Jia J. Preparative separation and purification of bufadienolides from Chinese traditional medicine of ChanSu using high-speed counter-current chromatography. J Sep Sci 2010,33:1325-1330 (通訊作者，2008SCI影響因子IF 2.746)
2. Yu Z, Li S, Lv SH, Piao H, Zhang YH, Zhang YM, Ma H, Zhang J, Sun CK(Corresponding Author), Li AP(Corresponding Author). Hypoxia-ischemia brain damage disrupts brain cholesterol homeostasis in neonatal rats. Neuropediatrics 2009,40(4):179-185 (通訊作者，2008SCI影響因子IF1.216)
3. Wu JL, Liu T, Lin Y, Shen ZW, Miao YW, Wu RH, Sun CK. Quantitative analysis of glutamate compounds in the swine brain following central analgesics nasal spray using proton magnetic resonance spectroscopy and linear combination model. Neural Regen Res 2009,4(7): 508-512 (SCI檢索期刊)
4..Du JL, Liu JF, Men LL, Yao JJ, Sun LP, Sun GH, Song GR, Yang Y, Bai R, Xing Q, Li CC, Sun CK (Corresponding Author). Efffects of five-year intensive multifactorial intervention on the serum amyloid A and macroangiopathy in patients with short-duration type 2 diabetes mellitus. Chin Med J 2009, 122(21): 2560-2566 (通訊作者，2008SCI影響因子IF 0.858)
5. Sun W, Sun CK, Lin H, Zhao H, Wang J, Ma H, Chen B, Xiao Z, Dai J. The effect of collagen-binding NGF-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model. Biomaterials 2009 Sep;30(27):4649-56. (2008SCI影響因子IF 6.646)
6. Sun W, Sun CK, Zhao H, Lin H, Han Q, Wang J, Ma H, Chen B, Xiao Z, Dai J. Improvement of sciatic nerve regeneration using laminin-binding human NGF-beta. PLoS One 2009 Jul 9;4(7):e6180 (2007 PLoS Clinical Trials SCI影響因子IF 4.774)
7. Chen X, Sun CK (Co-First Author), Han GZ, Peng JY, Li Y, Liu YX, Lv YY, Liu KX, Zhou Q, Sun HJ. Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significanly correlated with cytochrome P450 suppression. World J Gastroenterol 2009 Apr 21;15(15):1829-35(并列第一作者，2008SCI影響因子IF 2.081)
8. Yin LH, Lu BN, Qi Y, Xu LN, Xu H, Xu YW, Peng JY(Corresponding Author), Sun CK (Corresponding Author). Simultaneous determination of 11 active components in two well-known traditional Chinese medicines by HPLC coupled with diode array detection for quality control. J Pharm Biomed Anal 2009 May 1;49(4):1101-8 (通訊作者，2008SCI影響因子IF 2.629)
9. .Wang XF, Yang Q, Fan Z, Sun CK, Yue GH. Assessing time-dependent association between scalp EEG and muscle activation: a functional random-elects model approach. J Neurosci Methods 2009 Feb 15;177(1):232-40 (2008SCI影響因子IF 2.092)
10.Xu LN, Han X, Qi Y, Xu YW, Yin LH, Peng JY(Corresponding Author), Liu KX, Sun CK (Corresponding Author). Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. Anal Chim Acta 2009 Feb 2;633(1):136-48 (通訊作者，2008SCI影響因子IF 3.146)
11.Yang Q, Fang Y, Sun CK, Siemionow V, Ranganathan VK, Khoshknabi DS, Davis MP, Wash D, Sahgal V, Yue GH. Weakening of corticomuscular coupling during muscle fatigue. Brain Research, 2009 Jan 23; 1250: 101-112 (2008SCI影響因子IF 2.494)
12.Liang S, Yang F, Zhou C, Wang Y, Li S, Sun CK, Puglisi JL, Bers D, Sun C, Zheng J. Temperature-dependent activation of neurons by continuous near-infrared laser. Cell Biochem Biophys 2009; 53(1): 33-42 (2008SCI影響因子IF 2.257)
13.Zhan LB, Sui H, Lu XG, Sun CK, Zhang J, Ma H. Effects of Zibu Piyin Recipe on SNK-SPAR pathway in neuron injury induced by glutamate. Chin J Integr Med 2008 ,14(2):117-122 (SCI檢索期刊)
14.Liu S, Sun MZ, Sun CK, Zhao B, Greenaway FT, Zheng Q. A novel serine protease from the snake venom of Agkistrodon blomhoffii ussurensis. Toxicon. 2008; 52(7): 760-8 (SCI影響因子IF 2.460)
15.Zhang L, Butler AJ, Sun CK, Sahgal V, Wittenberg GF, Yue GH. Fractal dimension assessment of brain white matter structural complexity post stroke in relation to upper-extremity motor function. Brain Res 2008; 1228: 229-240 (SCI影響因子IF 2.494)
16.DU JL, Sun CK (Co-First Author), Lü B, MEN LL, YAO JJ, AN LJ, SONG GR. Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus. Chin Med J 2008; 121(13): 1165-1168(并列第一作者，SCI影響因子IF 0.858)
17.Wu LX, Sun CK (Corresponding Author)，Zhang YM, Fan M, Xu J, Ma H, Zhang J. Involvement of the Snk-SPAR pathway in glutamate-induced excitotoxicity in cultured hippocampal neurons. Brain Res 2007;1168:38-45 (通訊作者，SCI影響因子IF 2.218)
18. Du JL, An LJ, Sun CK, Men LL, Zhang XJ, Li CC. Overexpressing SelS may protect human umbilical vein endothelial cells from injuring by H2O2. Prog Biochem Biophys 2007, 34(4): 425-430(SCI影響因子IF 0.214)
19. Zhan LB, Lu XG, Sun CK, Wang DP, Sui H, Jiang WZ, Wei W, Ma H. Antiexcitoxicity of Zi-Bu-Pi-Yin Recipe in vitro and Mechanisms. Acta Pharmacol Sin 2006; 27 (Suppl): 352 (XVth World Congress of Pharmoclogy, Beijing, ISTP收錄，SCI影響因子IF 1.397)
20. Kang XN, Sun CK (Corresponding Author), Fan M, Xue YN, Shao NS, Zhao J, Han DY, Shi GX. Screening of a NMDA receptor epitope from random phage display peptide library. Prog Biochem Biophys 2003, 30 (4): 599-604 (通訊作者，SCI影響因子IF 0.048)
21. Kang XN, Sun CK (Corresponding Author), Fan M, Song ZJ, Zhao J, Wang JQ, Shi GX. Fourier transform infrared spectroscopic investigation of excitotoxicity-protective mechanism of monoclonal antibody against NMDAR. Prog Biochem Biophys 2003, 30 (2): 290-294(通訊作者，SCI影響因子IF 0.048)
22. Wu LX, Sun CK (Corresponding Author), Fan M . Nogo and Nogo receptor . Prog Biochem Biophys 2002, 29 (6): 834-836(通訊作者，SCI影響因子IF 0.160)
23.Sun CK, Ju G. Nitric oxide involved in epilepsy: Yes or no, what or why. Jpn J Pharmacol 1997,75(Suppl.1):89 (第五屆一氧化氮國際會議交流, ISTP收錄，SCI影響因子IF 1.210)
24.Sun CK, Ju G, Huang YG. Expression of interleukin-6 in rat hippocampal formation during kainic acid induced seizures and the roles of nitric oxide pathway. Epilepsia1997,38 (Suppl.3): 231(第22屆國際癲癎會議口頭報告, ISTP收錄，SCI影響因子IF 2.928)
25.Sun CK, Ju G, Huang YG. Implications of nitric oxide pathway in reactive gliosis within intractable seizure brain.Epilepsia1997,38(Suppl.3):189(第22屆國際癲癎會議交流，SCI影響因子IF 2.928)
26.Chen JW, Sun CK, Huang YG. Nitric Oxide Synthase: Biochemistry and Molecular Biology. Prog Biochem Biophys 1996, 23 (3): 293-297(SCI影響因子IF 0.041)
27.Sun CK, Chong XQ, Huang YG. Spongiform encephalopathies in mainland China. Lancet 1996, 348:544 (Research Letter)(SCI影響因子IF 17.948)
28.Sun CK, Huang YG, Wang DN,et al. An investigation of the GluRs-NOSs-RNI/ROIs cascade mechanism during the seizures induced by kainic acid in balb/c mice. Endothelium 1995,3:s119(Abstract)(第四屆一氧化氮國際會議交流, ISTP收錄，SCI影響因子1.146)
