基本內(nèi)容
周海夢 博士教授，博導(dǎo)
1970年，清華大學(xué)工程化學(xué)系 本科
1981年，清華大學(xué)應(yīng)用化學(xué) 碩士
1986年，中國科學(xué)院生物物理所 博士
現(xiàn)任清華大學(xué)教授，分子酶學(xué)實驗室主任
主要科研領(lǐng)域與方向：主要研究方向為酶的結(jié)構(gòu)與功能研究。包括酶的化學(xué)修飾、酶的催化動力學(xué)、酶結(jié)構(gòu)改變對生物活性的影響等。目前集中于蛋白質(zhì)折疊的研究，包括蛋白質(zhì)折疊中間體、折疊途徑等研究。
Selected Publications:
■ Zhao TJ, Ou WB, Xie Q, Liu Y, Yan YB* & Zhou HM*. 2005. Catalysis of creatine kinase refolding by protein disulfide isomerase involves disulfide cross-link and dimer to tetramer switch. J Biol Chem. 280(14):13470-13476.
■ Meng FG, Hong YK, He HW, Lyubarev AE, Kurganov BI, Yan YB* & Zhou HM*. 2004. Osmophobic effect of glycerol on irreversible thermal denaturation of rabbit creatine kinase. Biophys J. 87:2247-2254.
■ Pan JC, Yu Z, Su XY, Sun YQ, Rao XM & Zhou HM*.2004. Unassisted refolding of urea-denatured arginine kinase from shrimp Feneropenaeus chinensis: evidence for two equilibrium intermediates in the refolding pathway. Protein Sci. 13:1892-1901.
■ Meng FG, Park YD& Zhou HM*. Role of proline, glycine, and heparin sodium as protein folding aids during refolding of rabbit muscle creatine kinase. Int. J. Biochem. Cell Biol. 33:701-709.
■ Ou WB, Luo W, Park YD & Zhou HM*. 2001. Chaperone-like activity of peptidyl-prolyl cis-trans isomerase during creatine kinase refolding. Protein Sci. 10:2346-2353.
■ Ou WB, Park YD & Zhou HM*. 2001. Molecular mechanism for osmolytes protection of creatine kinase against guanidine denaturation. Eur. J. Biochem. 268:5901-5911.
