李量 - 個(gè)人簡(jiǎn)介
李量,男,北京市人,1962年生。1985年在北京大學(xué)獲心理學(xué)學(xué)士學(xué)位。1988年在北京大學(xué)獲生理心理學(xué)碩士學(xué)位。
李量 - 工作經(jīng)歷
1988至1989年在中國(guó)科學(xué)院心理所擔(dān)任助理研究員,從事建立小雞印記學(xué)習(xí)實(shí)驗(yàn)室的工作。
1994年在加拿大Carleton大學(xué)獲心理學(xué)哲學(xué)博士,專業(yè)神經(jīng)科學(xué)。
1994至1996年,獲得加拿大自然和工程學(xué)研究基金委員會(huì)(NSERC)的博士后經(jīng)費(fèi),在Queen’s大學(xué)做博士后工作。
1996至1997年在Queen’s 大學(xué)擔(dān)任講課助理教授。
1997至2000年在加拿大多倫多大學(xué)做博士后工作。
1997至1998年擔(dān)任加拿大自然和工程學(xué)研究基金委員會(huì)委員。
1999至2000年擔(dān)任北京大學(xué)心理系客座教授。
2000年起為北京大學(xué)心理系教授、"985"生理心理學(xué)科建設(shè)帶頭人。
2001年起為北京大學(xué)腦與認(rèn)知科學(xué)研究中心骨干科學(xué)家、加拿大多倫多大學(xué)生物通訊系統(tǒng)研究中心研究員。
2002年起為北京大學(xué)聽覺(jué)與言語(yǔ)研究中心骨干科學(xué)家及學(xué)術(shù)委員會(huì)副主任。
李量 - 研究領(lǐng)域
李量教授的研究興趣主要集中在有關(guān)認(rèn)知過(guò)程與感覺(jué)門控過(guò)程之間的交互作用機(jī)理的研究上。具體來(lái)講,在建立動(dòng)物與人的感覺(jué)門控模型的基礎(chǔ)上,系統(tǒng)地研究聽覺(jué)門控過(guò)程是如何被觸發(fā)和終止的,聽覺(jué)空間信息如何在感覺(jué)門控神經(jīng)環(huán)路中進(jìn)行表達(dá),感覺(jué)門控過(guò)程如何對(duì)知覺(jué)與記憶過(guò)程提供即時(shí)性的保護(hù)作用,以及感覺(jué)門控過(guò)程如何受到注意、動(dòng)機(jī)和情緒的調(diào)節(jié)。上述研究正在擴(kuò)展到兒童心理發(fā)育、老年過(guò)程、語(yǔ)言障礙以及精神疾病模型的建立上。
李量教授的實(shí)驗(yàn)室在國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目、面上項(xiàng)目、國(guó)際合作項(xiàng)目、主任基金,985計(jì)劃,教育部博士點(diǎn)基金,以及國(guó)家“973”項(xiàng)目的支持下,正在深入而系統(tǒng)化地研究以下五個(gè)方面的問(wèn)題。同時(shí),對(duì)這些問(wèn)題的研究還擴(kuò)展到言語(yǔ)通訊、跨語(yǔ)言比較(如中英文的比較)、人工耳蝸、兒童心理發(fā)育、聽覺(jué)老年過(guò)程、以及精神分裂癥等應(yīng)用領(lǐng)域。所使用的實(shí)驗(yàn)技術(shù)包括心理物理學(xué)(實(shí)驗(yàn)心理學(xué))測(cè)量、核磁共振腦成像、多導(dǎo)腦磁記錄、多導(dǎo)頭皮電活動(dòng)記錄、動(dòng)物行為模型、動(dòng)物神經(jīng)電生理、動(dòng)物神經(jīng)光學(xué)腦成像等。
(一)初始聽覺(jué)記憶
視覺(jué)系統(tǒng)的一個(gè)重要的信號(hào)加工策略是以降低時(shí)間分辨率(如眼球顫動(dòng)的功能)為代價(jià)來(lái)增強(qiáng)加工的空間分辨率,但聽覺(jué)系統(tǒng)則要處理在時(shí)間序列上的信息輸入并具有極高的時(shí)間分辨率。因此,聲音信號(hào)中的原始精細(xì)結(jié)構(gòu)在腦內(nèi)的暫存是在時(shí)間整合基礎(chǔ)上的聽覺(jué)客體(auditory object)形成所不可缺少的。這種所謂的“初始聽覺(jué)記憶”發(fā)生在傳統(tǒng)的感覺(jué)記憶之前,并具有容量大、抗干擾性強(qiáng)以及持續(xù)時(shí)間短等重要特征。我們最新的心理物理學(xué)實(shí)驗(yàn)和腦電實(shí)驗(yàn)結(jié)果表明,對(duì)噪音精細(xì)結(jié)構(gòu)的初始聽覺(jué)記憶的保持時(shí)間在人類聽者之間有很大的差異,可以從幾毫秒到二十幾毫秒,并與噪音中的頻率成分有關(guān)。再進(jìn)一步,因?yàn)樵谟谢芈暤穆晫W(xué)環(huán)境中,聽覺(jué)系統(tǒng)對(duì)直達(dá)聲與反射聲的知覺(jué)整合極大地依賴于直達(dá)聲的信息在初始聽覺(jué)記憶中的保持,因此這種原始性的聽覺(jué)記憶形式是實(shí)現(xiàn)聲音信號(hào)的跨時(shí)間的相關(guān)性計(jì)算所必要的,并與人類聽者的抗掩蔽能力有密切的關(guān)系。進(jìn)一步探究這種初始聽覺(jué)記憶的特性、功能以及相應(yīng)的神經(jīng)機(jī)制將是聽覺(jué)領(lǐng)域中的一個(gè)重要課題。初始聽覺(jué)記憶的工作容量有多大?初始聽覺(jué)記憶能夠保持多久?這種記憶形式是否有可塑性?老年被試的這種記憶保持時(shí)間有無(wú)減少? 兩個(gè)寬帶聲音信號(hào)的相關(guān)性神經(jīng)計(jì)算是如何實(shí)現(xiàn)的?這些都是我們實(shí)驗(yàn)室目前所研究的幾個(gè)具體的問(wèn)題。
(二)聽覺(jué)的雙耳加工
聽覺(jué)系統(tǒng)是動(dòng)物最重要的“早期警報(bào)系統(tǒng)”,不僅能探察趨近的捕食者或被掠物發(fā)出的聲音,還能確定其方向。對(duì)外在目標(biāo)進(jìn)行空間定位,是視覺(jué)與聽覺(jué)的主要功能之一。然而,與視覺(jué)系統(tǒng)空間感知的神經(jīng)機(jī)制不同,聽覺(jué)感受器僅編碼聲音頻率,不編碼聲源位置。精確的聲源定位,必須由聽覺(jué)中樞通過(guò)比較聲音輸入雙耳所誘發(fā)的神經(jīng)信號(hào)才能實(shí)現(xiàn)。聲源空間線索主要包括聲音到達(dá)雙耳的時(shí)間差(interaural time difference, ITD)和雙耳間聲強(qiáng)差(interaural level difference, ILD)。但聽覺(jué)系統(tǒng)如何用雙耳線索來(lái)進(jìn)行聲源定位還是一個(gè)未解之謎。
(三)“雞尾酒會(huì)”問(wèn)題
在嘈雜的聲學(xué)環(huán)境中,如果目標(biāo)聲音和干擾聲音都是言語(yǔ),目標(biāo)聲音所受到的干擾影響可以分成能量掩蔽(energetic masking)和信息掩蔽(informational masking)。能量掩蔽發(fā)生在聽覺(jué)系統(tǒng)的外周部分。當(dāng)掩蔽聲音和目標(biāo)聲音同時(shí)出現(xiàn),尤其兩者在頻譜上重疊時(shí),聽覺(jué)系統(tǒng)對(duì)目標(biāo)聲音的動(dòng)態(tài)反應(yīng)就會(huì)下降,進(jìn)而覺(jué)察和辨認(rèn)目標(biāo)聲音所需要的信噪比被提高。能量掩蔽使進(jìn)入高級(jí)中樞的目標(biāo)信息有實(shí)質(zhì)性的缺失,而這種缺失是任何高級(jí)中樞的加工所不能補(bǔ)償?shù)摹H欢,信息掩蔽是另外一種更復(fù)雜、發(fā)生在高級(jí)中樞階段的掩蔽作用。當(dāng)掩蔽聲音和目標(biāo)聲音在某些信息維度上有一定的相似性時(shí),例如當(dāng)目標(biāo)聲音與掩蔽聲音都是言語(yǔ)時(shí),一些神經(jīng)/心理資源就會(huì)被用于對(duì)掩蔽聲音的加工,目標(biāo)聲音和掩蔽聲音之間就會(huì)在高級(jí)加工層次上出現(xiàn)競(jìng)爭(zhēng)與混淆,從而使目標(biāo)信號(hào)受到了掩蔽作用。從信號(hào)加工的觀點(diǎn)來(lái)看,分離目標(biāo)言語(yǔ)成分與掩蔽言語(yǔ)成分,并對(duì)目標(biāo)言語(yǔ)成分進(jìn)行組合是一個(gè)非常困難的任務(wù)。盡管近年來(lái)信息科學(xué)和計(jì)算機(jī)技術(shù)有了快速的發(fā)展,但到目前為止還沒(méi)有任何計(jì)算機(jī)言語(yǔ)識(shí)別系統(tǒng)能在有干擾言語(yǔ)的環(huán)境下實(shí)現(xiàn)對(duì)目標(biāo)言語(yǔ)的有效識(shí)別。然而,在有干擾言語(yǔ)的環(huán)境下,具有正常聽力的人卻能在相當(dāng)?shù)某潭壬侠斫馑P(guān)注的語(yǔ)句的內(nèi)容,這是為什么呢?就是在半個(gè)世紀(jì)前由Cherry (1953) 所提出的著名的“雞尾酒會(huì)”問(wèn)題。
我們近期的工作表明,在嘈雜的“雞尾酒會(huì)”環(huán)境中,當(dāng)目標(biāo)語(yǔ)句本身的一些特性能保持一定的穩(wěn)定性時(shí),聽者可以利用這些與目標(biāo)語(yǔ)句相關(guān)的各種知覺(jué)線索來(lái)覺(jué)察、捕捉和追隨目標(biāo)語(yǔ)句流,以達(dá)到減少信息掩蔽的目的。這些知覺(jué)線索包括, 目標(biāo)語(yǔ)句與掩蔽刺激的主觀空間分離、與目標(biāo)語(yǔ)句有動(dòng)態(tài)相關(guān)性的視覺(jué)刺激、對(duì)目標(biāo)嗓音和目標(biāo)語(yǔ)句部分內(nèi)容的熟悉程度等。 這也表明,在“雞尾酒會(huì)”這個(gè)重要的問(wèn)題中,人類高級(jí)認(rèn)知加工過(guò)程起了關(guān)鍵的作用。對(duì)各種知覺(jué)線索的利用是一個(gè)復(fù)雜的動(dòng)態(tài)過(guò)程。在不同情況下,各個(gè)線索的顯現(xiàn)程度會(huì)隨時(shí)間發(fā)生波動(dòng),因而聽者會(huì)在不同的條件下選擇利用不同的線索組合來(lái)減少信息掩蔽。這樣,認(rèn)識(shí)各個(gè)線索之間所存在著復(fù)雜的交互作用是破解“雞尾酒會(huì)”問(wèn)題的關(guān)鍵所在。
(四)精神分裂癥的動(dòng)物模型
由強(qiáng)感覺(jué)刺激所引起的驚反射是一種建立在簡(jiǎn)單中樞環(huán)路基礎(chǔ)上的對(duì)威脅性刺激的全身性反射活動(dòng),具有重要的生態(tài)學(xué)意義,但也能干擾認(rèn)知活動(dòng)。中樞系統(tǒng)也具有能抑制驚反射的機(jī)制。前脈沖抑制(prepulse inhibition, PPI)是出現(xiàn)在驚反射刺激之前的弱感覺(jué)刺激(前脈沖刺激)對(duì)驚反射所產(chǎn)生的抑制作用。Graham的“加工-保護(hù)”理論(the Protection-of-Processing Theory)認(rèn)為,前脈沖刺激除了引發(fā)對(duì)該刺激的中樞加工外,也引發(fā)了一個(gè)門控過(guò)程以削弱對(duì)隨后強(qiáng)干擾刺激的加工,以此來(lái)保護(hù)對(duì)前脈沖信號(hào)的加工。PPI實(shí)際上是通過(guò)運(yùn)動(dòng)系統(tǒng)的活動(dòng)來(lái)反映腦內(nèi)信息加工的門控過(guò)程。盡管PPI環(huán)路位于包括下丘、上丘深層、以及橋腦腳被蓋核的腦干部位,但它與感覺(jué)皮層、運(yùn)動(dòng)系統(tǒng)、上行激活系統(tǒng)以及邊緣系統(tǒng)有廣泛的神經(jīng)聯(lián)系并受到復(fù)雜的調(diào)節(jié)作用。PPI在精神分裂癥病人中有顯著的缺失,而抗精神藥物在緩解癥狀的同時(shí)也減少PPI的缺失。因此,PPI的缺失與精神分裂癥之間的關(guān)系成為了當(dāng)今國(guó)際上研究精神分裂癥的神經(jīng)和心理機(jī)制的一個(gè)重要題目。動(dòng)物實(shí)驗(yàn)研究也證實(shí),藥物性調(diào)節(jié)或損毀與精神分裂癥有關(guān)的某些腦區(qū)以及引入早期不良刺激都可以造成大鼠PPI的缺失。
更重要的是,對(duì)前脈沖刺激的注意和認(rèn)知加工可以顯著地調(diào)節(jié)PPI,而有情緒內(nèi)容的前脈沖刺激(如令人恐懼的圖片)所引起的PPI也顯著地強(qiáng)于由中性前脈沖刺激所引起的PPI。已有豐富的研究報(bào)告顯示,在精神分裂癥病人中,不但基線PPI有缺失,而注意對(duì)PPI的調(diào)節(jié)作用也有顯著的缺失,而只有注意對(duì)PPI調(diào)節(jié)作用的缺失才與精神分裂癥的幾種特異性癥狀之間有顯著的相關(guān)。因此,研究對(duì)PPI的認(rèn)知調(diào)節(jié)不僅可以將對(duì)PPI的研究擴(kuò)展到認(rèn)知層次,而且可以使對(duì)精神分裂癥機(jī)制的認(rèn)識(shí)更加深入化,還可以為發(fā)展新的精神分裂癥的動(dòng)物模型供依據(jù)。我們實(shí)驗(yàn)室在國(guó)際上首次報(bào)告了大鼠的聽覺(jué)情緒學(xué)習(xí)可以顯著地增強(qiáng)PPI,即當(dāng)前脈沖刺激經(jīng)過(guò)與足底電擊的結(jié)合而被恐懼條件化進(jìn)而具有了生態(tài)學(xué)意義后,大鼠對(duì)該刺激的注意程度增高,從而強(qiáng)化了中樞對(duì)前脈沖刺激的加工。然而,大鼠的隔離飼養(yǎng)能破壞聽覺(jué)恐懼條件化對(duì)PPI的增強(qiáng)作用。這就為建立新一代的精神分裂癥的工作模型提供了重要的前期工作基礎(chǔ)。
(五)情緒學(xué)習(xí)的神經(jīng)生物學(xué)機(jī)制
杏仁核接受聽覺(jué)系統(tǒng)和軀體感覺(jué)系統(tǒng)的神經(jīng)輸入,并在聽覺(jué)情緒學(xué)習(xí)中起著關(guān)鍵的作用。由杏仁核所中介的情緒學(xué)習(xí)在驚反射和驚反射的前脈沖抑制上均有顯著的行為表達(dá)。本實(shí)驗(yàn)室利用對(duì)前脈沖抑制的聽覺(jué)條件化作為恐懼情緒學(xué)習(xí)的行為模型,來(lái)研究情緒學(xué)習(xí)及其表達(dá)的神經(jīng)生物學(xué)機(jī)制。
李量 - 主要論著
英文論著
Du, Y., Kong, L.-Z., Wang, Q., and Wu, X.-H., Li, L. Auditory frequency-following response: a neurophysiological measure for studying the “cocktail-party problem. Neuroscience and Biobehavioral Reviews, in press.
Ezzatian, P., Li, L., Pichora-Fuller, K., Schneider, B. The effect of energetic and informational masking on the time-course of stream segregation: Evidence that streaming depends on vocal fine structure cues. Language and Cognitive Processes, in press.
Wu, X.-H., Yang, Z.-G., Huang, Y., Chen, J., Li, L., Daneman, M., Schneider, B.A. Cross-language differences in informational masking of speech by speech: English versus Mandarin Chinese. Journal of Speech, Language, and Hearing Research, accepted.
Cao, S.-Y., Li, L., and Wu, X.-H. (2011). Improvement of intelligibility of ideal binary-masked noisy speech by adding background noise. Journal of the Acoustical Society of America, 129, 2227-2236.
Wang, M.-Y., Wu, X.-H., Li, L., and Schneider, B. (2011). The effects of age and interaural delay on detecting a change in interaural correlation: The role of temporal jitter. Hearing Research, 275,139-149.
Du, Y., He, Y., Ross, B., Bardouille, T., Wu, X.-H., Li, L., Alain, C. (2011). Human auditory cortex activity shows additive effects of spectral and spatial cues during speech segregation. Cerebral Cortex, 21, 698-707.
Ezzatian, P., Li, L., Pichora-Fuller, K., Schneider, B. (2011). The Effect of Priming on Release from Informational Masking is Equivalent for Younger and Older Adults. Ear and Hearing, 32(1):84-96.
Huang, Y., Li, J.-Y., Zou, X.-F., Qu, T.-S., Wu, X.-H., Mao, L.-H., Wu, Y.-H., Li, L. (2011). Perceptual fusion tendency of speech sounds. Journal of Cognitive Neuroscience, 23, 1003-1014.
Huang, Y., Xu, L.-J., Wu, X.-H., Li, L. (2010). The effect of voice cuing on releasing speech from informational masking disappears in older adults. Ear and Hearing, 31, 579–583.
Du, Y., Wu, X.-H., Li, L. (2010). Emotional learning enhances stimulus-specific top-down modulation of sensorimotor gating in socially reared rats but not isolation-reared rats. Behavioural Brain Research, 206, 192-201.
Du, Y., Ma, T.-F., Wang, Q., Wu, X.-H., Li, L. (2009). Two crossed axonal projections contribute to binaural unmasking of frequency-following responses in rat inferior colliculus. European Journal of Neuroscience, 30, 1779-1789.
Huang, Y., Huang, Q., Chen, X., Wu, X.-H., Li, L. (2009a). Transient auditory storage of acoustic details is associated with release of speech from informational masking in reverberant conditions. Journal of Experimental Psychology: Human Perception and Performance, 35, 1618-1628.
Huang, Y., Wu, X.-H., Li, L. (2009b). Detection of the break in interaural correlation is affected by interaural delay, aging, and center frequency. Journal of the Acoustical Society of America, 126, 300-309.
Li, L., Yan, J. (2009). The First International Symposium on Neurobehavioral Science in China (Editorial). Neuroscience and Biobehavioral Reviews, 33, 1155-1156.
Li, L., Du, Y., Li, N.-X., Wu, X.-H., Wu, Y.-H. (2009). Top-down modulation of prepulse inhibition the startle reflex in humans and rats. Neuroscience and Biobehavioral Reviews, 33, 1157-1167.
Du, Y., Huang, Q., Wu, X.-H., Galbraith, G.C., Li, L. (2009). Binaural unmasking of frequency-following responses in rat amygdala. Journal of Neurophysiology, 101, 1647-1659.
Du, Y., Li, J.-Y., Wu, X.-H., Li, L. (2009). Precedence effect-induced enhancement of prepulse inhibition in socially reared but not isolation-reared rats. Cognitive, Affective, and Behavioral Neuroscience, 9, 44-58.
Li, L., Huang, J., Wu, X.-H., Qi, J.G., Schneider, B. (2009). The effects of aging and interaural delay on the detection of a break in the interaural correlation between two sounds. Ear and Hearing, 30, 273-286.
Chen, J., Wu, X.-H., Li, L., Chi, H.-S. (2009). Simulated phase-locking stimulation: An improved speech processing strategy for cochlear implant. Journal for Oto-Rhino-Laryngology and its Related Specialties, 71,221-227.
Huang, Y., Kong, L.-Z., Fan, S.-L., Wu, X.-H., Li, L. (2008a). Both frequency and interaural delay affect ERP responses to binaural gap. NeuroReport, 19,1673-1678.
Huang, Y., Huang, Q., Chen, X., Qu, T.-S., Wu, X.-H., Li, L. (2008b). Perceptual integration between target speech and target-speech reflection reduces masking for target-speech recognition in younger adults and older adults. Hearing Research, 244, 51-65.
Ping, J.-L. Li, N.-X., Galbraith, G. C., Wu, X.-H. Li, L. (2008). Auditory frequency-following responses in rat ipsilateral inferior colliculus. NeuroReport, 19, 1377-1380.
Li , N.-X., Ping , J.-L., Wu , R.-B., Wang , C., Wu , X.-H., Li, L. (2008). Auditory fear conditioning modulates prepulse inhibition in socially-reared rats and isolation-reared rats. Behavioral Neuroscience, 122, 107-118.
Zheng, J.-W., Wu, X.-H., Li, L. (2008). Metabotropic glutamate receptors subtype 5 are necessary for the enhancement of auditory evoked potentials in the lateral nucleus of the amygdala by tetanic stimulation of the auditory thalamus. Neuroscience, 152, 254-264.
Wang, W.J., Wu, X.-H., Li, L. (2008). The dual-pathway model of auditory signal processing. Neuroscience Bulletin, 24, 173-182.
Kong, L.Z., Wu, X.-H., Li, Li. (2008). The role of hippocampus in the context-specific extinction of cue fear. Neural Regeneration Research, 12, 1386-1390
Yang, Z.-G., Chen, J., Wu, X.-H., Wu, Y.-H., Schneider, B.A., Li, L. (2007). The effect of voice cuing on releasing Chinese speech from informational masking. Speech Communication, 49, 892-904.
Du, Y., Ping, J.-L., Li, N.-X., Wu, X.-H., Li, L., Galbraith, G. (2007). Ultrasonic auditory evoked response recorded in the rat’s cochlear nucleus. Brain Research, 1172, 40-47.
Wu, X.-H., Chen, J., Yang, Z.-G., Huang, Q., Wang, M.-Y., Li, L. (2007). Effect of number of masking talkers on speech-on-speech masking in Chinese. Interspeech, 390-393.
Ping, J.-L., Li, N.-X., Du, Y., Wu, X.-H., Li, L., Galbraith, G. (2007). Auditory evoked responses in the rat: transverse subdermal electrodes register before cochlear nucleus and do not reflect later inferior colliculus activity. Journal of Neuroscience Methods, 161, 11-16.
Li, N.-X., Wu, X.-H., Li, L. (2007). Chronic administration of clozapine alleviates reversal learning impairment in isolation reared rats. Behavioural Pharmacology, 18, 135-145.
Zou, D., Huang J., Wu, X.-H., Li, L. (2007). Metabotropic glutamate subtype 5 receptors modulate fear-conditioning induced enhancement of prepulse inhibition in rats. Neuropharmacology, 52, 476-486.
Huang, J., Yang, Z.-G., Ping, J.-L., Liu, X., Wu, X.-H., Li, L. (2007). The influence of the perceptual or fear learning on rats’prepulse inhibition induced by changes in the correlation between two spatially separated noise sounds. Hearing Research, 223, 1-10.
Schneider, B.A., Li, L., Daneman, M. (2007). How noise interferes with speech comprehension in everyday listening situations? Journal of the American Academy of Audiology, 18, 578-591.
Yeomans, J.S., Lee, J., Yeomans, M.H., Steidl, S., Li, L. (2006). Midbrain pathways for prepulse inhibition and startle activation in rat. Neuroscience, 142, 921-929.
Du, Y., Wu, X.-H., Li, L. (2006). Mechanisms of bacterial meningitis-related deafness. Drug Discovery Today: Disease Mechanisms, 3, 115-118.
Huang, J., Xihong Wu, X.-H., John Yeomans, J.S., Li, L. (2005). Opposite effects of tetanic stimulation of the auditory thalamus or auditory cortex on the acoustic startle reflex in awake rats. European Journal of Neuroscience, 21, 1943-1956.
He, S.-C., Huang, J., Wu, X.-H., Li, L. (2005). Glutamate and GABAB transmissions in lateral amygdala are involved in startle-like EMG potentiation caused by activation of auditory thalamus. Neuroscience Letters, 374, 113-118.
Li, L., Qi, J.G., He, Y., Alain, C., and Schneider, B. (2005). Attribute capture in the precedence effect for long-duration noise sounds. Hearing Research, 202, 235-247.
Wu, X-H, Wang, C., Chen, J., Qu, H-W, Li, W-R, Wu, Y-H, Schneider, B.A, Li, L. (2005). The effect of perceived spatial separation on informational masking of Chinese speech. Hearing Research, 199, 1-10.
Li, L., Daneman, M., Qi, J.G., and Schneider, B. A. (2004). Does the information content of an irrelevant source differentially affect speech recognition in younger and older adults? Journal of Experimental Psychology:Human Perception and Performance, 30, 1077-1091.
Steidl, S., Faerman, P., Li, L. and Yeomans J.S. (2004)Kynurenate in the pontine reticular formation inhibits acoustic and trigeminal nucleus-evoked startle, but not vestibular nucleus-evoked startle. Neuroscience, 126, 127-136.
Jiang, M-L, Han, T-Z, Pang, W., and Li, L. (2004) Gender- and age- specific impairment of rats’s performance in Morris water maze following prenatal exposure to the MRI magnetic field. Brain Research, 995, 140-144.
Chen, J., Wang, C., Qu, H.-W., Li, W.-R., Wu, Y.-H., Wu, X.-H., Schneider, B.A, Li, L. (2004). Perceived spatial separation induced by the precedence effect releases Chinese speech from informational masking. Canadian Acoustics, 32, 186-187
Li, L., and Shao, F. (2003). Impaired sensorimotor gating: An animal model of schizophrenia. Chinese Science Bulletin, 48, 2031-2037.
Yeomans, J.S., Li, L., Scott, B.W., and Frankland, P.W. (2002) Tactile, acoustic and vestibular systems sum to elicit the startle reflex. Neuroscience and Biobehavioral Reviews, 26, 1-11.
Lin, C-M, Wan, X., Zhao, W., Ma, C., Ma, C-F, Gao, Y., Zhou, Y., Yeomans, J.S., and Li, L. (2002). Enhancement of electrically evoked startle-like responses by tetanic stimulation of the superior colliculus. NeuroReport, 13, 1769-1773.
Li, L. and Yue, Q. (2002) Auditory gating processes and binaural inhibition in the inferior colliculus. Hearing Research, 168, 113-124.
Fendt, M., Li, L., and Yeomans, J.S. (2001) Brainstem circuits mediating prepulse inhibition of the startle reflex. Psychopharmacology, 156, 216-224.
Steidl, S., Li, L., and Yeomans, J.S. (2001) Conditioned brain-stimulation reward attenuates the acoustic startle reflex in rats. Behavioral Neuroscience, 115, 710-717.
Li, L., Steidl, S., and Yeomans, J.S. (2001) Contributions of the vestibular nucleus and vestibulospinal tract to the startle reflex. Neuroscience, 106, 811-821.
Li, L. and Yeomans, J.S. (2000). Using intracranial electrical stimulation to study the timing of prepulse inhibition. Brain Research Protocols, 5, 67-74.
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中文論著
中文文章
徐李娟、 黃瑩、 吳璽宏、 吳艷紅、 李量 “雞尾酒會(huì)”環(huán)境中的知覺(jué)線索的去掩蔽作用。心理科學(xué)進(jìn)展,17, 261-267。
吳超、李量 (2009)研究人類注意缺陷多動(dòng)障礙的大鼠模型。中華精神科雜志,印刷中。
孔令志、吳璽宏、李 量 (2009) 杏仁核內(nèi)GABA介質(zhì)傳遞及其在恐懼消退中的作用, 生理科學(xué)進(jìn)展, 40, 63-66。
李量、李楠欣 (2008)建立新一代的精神分裂癥的動(dòng)物模型。心理科學(xué)進(jìn)展, 16,399-403。
鄭佳威、吳璽宏、李量 (2007)外側(cè)杏仁核在恐懼性條件化學(xué)習(xí)和記憶中的作用。生理科學(xué)進(jìn)展,38, 269-272。
杜憶、劉良發(fā)、李永新、吳璽宏、李量 (2007)細(xì)菌性腦膜炎致聾研究進(jìn)展。中華醫(yī)學(xué)雜志,87,1147-1149。
李楠欣、平俊麗、吳璽宏、 李量 (2006) 精神分裂癥的神經(jīng)發(fā)育動(dòng)物模型研究. 中國(guó)臨床康復(fù), 10, 154-157。
鄒丹、黃娟、李量 (2005) 聽覺(jué)情緒學(xué)習(xí)及其神經(jīng)機(jī)制.中國(guó)臨床康復(fù), 9, 149-151。
吳艷紅,李文瑞,陳婧,王純,曲宏偉,吳璽宏,李量 (2005) 主觀空間分離下的漢語(yǔ)信息掩蔽效應(yīng). 聲學(xué)學(xué)報(bào), 30, 462-467。
吳璽宏、馬成、陳婧、李量、遲惠生 (2003)一種測(cè)量聽覺(jué)系統(tǒng)時(shí)間分辨率的新方法. 中國(guó)聽力語(yǔ)言康復(fù)科學(xué)雜志, 1, 13-15。
李量、邵楓(2003)精神分裂癥的聽感覺(jué)運(yùn)動(dòng)門控障礙的動(dòng)物模型?茖W(xué)通報(bào),48, 1603-1612。
王浩然、李量、高祥榮 (2003) 基因芯片技術(shù)和蛋白質(zhì)組技術(shù)在神經(jīng)科學(xué)中的應(yīng)用及其研究進(jìn)展。生理科學(xué)進(jìn)展,34卷, 第二期, 121-126。
李量(2001)外側(cè)丘系背核中的谷氨酸遞質(zhì)傳遞對(duì)聽覺(jué)中腦下丘中的雙耳抑制反應(yīng)的調(diào)制。復(fù)旦神經(jīng)生物學(xué)講座,XVII, 55-66。
李量、肖。1995)老年與青年大鼠學(xué)習(xí)記憶的比較及其與腦內(nèi)NADH含量的關(guān)系。 現(xiàn)代老年醫(yī)學(xué)雜志,4,92-95。
專業(yè)書的章節(jié)
李量、馬成、岳琦。兩種研究大鼠的感覺(jué)運(yùn)動(dòng)門控與感知覺(jué)編碼交互作用的全自動(dòng)化迷宮。馬原野、王建紅(主編)認(rèn)知神經(jīng)科學(xué)原理和方法。重慶出版社,重慶。2003年4月出版,第310-316頁(yè)。
李量、童佳瑾、楊珉、劉均。感覺(jué)意識(shí)形成的四個(gè)基本要素: 編碼、激活、門控和感覺(jué)記憶。汪云九、楊玉芳(編輯)意識(shí)與大腦。人民出版社,北京。2003年9月出版,第115-123頁(yè)。
李量、陳林、王小勤。聽覺(jué)。韓濟(jì)生(主編)神經(jīng)科學(xué)。北京大學(xué)醫(yī)學(xué)出版社,北京。2009年1月出版,(第三版)第十四章,第595-617頁(yè)。