主要研究方向
以蛋白質(zhì)晶體X射線衍射為主要手段，結(jié)合多種生物化學(xué)和生物物理等方法，研究RNA沉默和表觀遺傳學(xué)領(lǐng)域中蛋白質(zhì)與核酸、蛋白質(zhì)與蛋白質(zhì)之間相互作用的三維結(jié)構(gòu)基礎(chǔ)及其重要成份的分子機(jī)制。
Using X-ray crystallography as a major method, in combination with various biophysical and biochemical methods，to study the 3-D structural basis of protein-nucleic acid and protein-protein interactions and molecular mechanisms of key components in the fields of RNA silencing and epigenetics.
獲獎(jiǎng)情況
曾獲V學(xué)者獎(jiǎng) (The V Scholar Award), Junior Faculty Development Grants (JFDG) 等。
1. Ma, J.B., Ye, K. and Patel, D.J.(2004). Structural basis for overhang-specific small interfereing RNA recognition by the PAZ domain. .429:318-322.
2. Phan, A.T., Kuryavyi, A., Ma, J.B., Andreola, M.L. and Patel, D.J.(2005). An interlocked dimmeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase. . 102:634-639.
3. Ma, J.B., Yuan, Y.R., Meister, G., Pei, Y., Tuschl, T. and Patel, D.J.(2005). Structural basis for 5’-end-specific recognition of guide RNA by the Piwi protein. . 434:666-670.
4. Yuan, Y.R., Pei, Y., Ma, J.B., Kuryavyi, V., Zhadina, M., Meister, G., Chen, H.Y., Dauter, Z., Tuschl, T.and Patel, D.J. (2005). Crystal structure of Argonaute, a site-specific DNA-guided RNA endonuclease, provides insights into RISC-mediated mRNA cleavage. . 19:405-419.
5. Huang, Y. , Ji, L., Huang, Q., Vassylyev, D.G., Chen, X., Ma, J.B.* (2009). Structural insights into mechanisms of the small RNA methyltransferase HEN1. 461:823-827.
